Efficacy and safety of treatments for childhood psoriasis: A systematic literature review

Jager, M.E.A. de; Jong, E.M.G.J. de; Kerkhof, P.C.M. van de; Seyger, M.M.B.

doi:10.1016/j.jaad.2009.06.048

Cited by 126 publications

(158 citation statements)

References 115 publications

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“…Başlangıç yeri en sık gövde (30 hasta, %46.9), saçlı deri (18 hasta, %28.1), diz-dirsek (7 hasta, %10.9), ekstremiteler (5 hasta, %7.9) ve palmoplantar (4 …”

Section: Bulgularunclassified

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The Retrospective Evaluation of Childhood Psoriasis Clinically and Demographic Features

Karadağ¹,

Bilgili²,

Çalka³

et al. 2013

tdd

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Objective: This study was aimed to define the clinical and demographic findings of psoriasis in childhood. Methods: In this retrospective study, the data from 64 children with psoriasis admitted at the our dermatology clinic between January 2007 and January 2011 were included whose data were fully. Results: Of the patients, 37 (57.8%) were boys and 27 (42.2%) were girls. Mean age of the children was 10.08 ±3.98 years (3-16). In 10 (15%) cases, a positive family history was detected. The most frequent localizations at onset were trunk (46.9%), scalp (28.1%), knee-elbow (10.9%) and extremities (7.9%), respectively. The most commonly seen clinical types were plaque (68.8%), guttate (20.3%), palmoplantar (9.4%), pustular (1.6%), respectively. Nine children had nail involvement. Out of all patients, 21.9% had upper respiratory tract infections and 9.4% had emotional stres. Four cases were diagnosed with depression. Of the cases, two cases were on non-steroid anti-inflammatory medication, and 4 of them were on antibiotics. Systemic treatments were given to 21.9% of the cases besides topical treatments. Conclusion:The epidemiological studies of psoriasis during childhood period for different countries have been reported. In this study, the ratio shows differences when compared to those previous studies. There are few epidemiologic studies for Turkey. We believe that further epidemiological studies including large number of patients' groups will contribute the diagnosis and treatment of the disease. Key words: Psoriasis, retrospective Sonuç: Çocukluk çağında görülen Psoriasisle ilgili farklı ülkeleri kapsayan çeşitli epidemiyolojik çalışmalar mevcuttur ve bu çalışmalarda bildirilen oranlar arasında farklılıklar bulunmaktadır. Ülkemizden bildirilen az sayıda epidemiyolojik çalışma mevcuttur. Daha geniş hasta gruplarını içeren çalışmalarla sağlanacak verilerin hastalığın tanı ve tedavisine katkıda bulunacağını düşünmekteyiz.

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“…Başlangıç yeri en sık gövde (30 hasta, %46.9), saçlı deri (18 hasta, %28.1), diz-dirsek (7 hasta, %10.9), ekstremiteler (5 hasta, %7.9) ve palmoplantar (4 …”

Section: Bulgularunclassified

“…Psoriasis toplumun yaklaşık %2-3,5'ini etkileyen, kronik, ataklarla seyreden, değişken klinik spektrumu olan bir hastalıktır (1)(2)(3)(4)(5). Hastaların yaklaşık %25-45'inde çocukluk veya adolesan dönemde ilk belirtiler oluşmaktadır (1)(2)(3).…”

Section: Introductionunclassified

The Retrospective Evaluation of Childhood Psoriasis Clinically and Demographic Features

Karadağ¹,

Bilgili²,

Çalka³

et al. 2013

tdd

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“…The real linear type without typical psoriatic lesions plaques is very rare and should be differentiated from inflammatory linear verrucous epidermal nevus (ILVEN), (10,11,15,19,20). Zonal form of the disease presents at the site of herpes zoster lesions following the Koebner phenomenon (10,11,15,19,20).…”

Section: Linear and Zonal Lesionsmentioning

confidence: 99%

“…The seborrheic lesions in this form of psoriasis manifests in scalp, eyebrow and post auricular skin associated with signs of both the two types of diseases (10,11,15,19,20).…”

Section: Seborrheic Psoriasismentioning

confidence: 99%

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Management of Psoriasis in Children: a Narrative Review

Hajheydari¹,

Sarparast²,

Shahmohammadi³

2015

J Pediatr Rev

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Psoriasis is an inherited chronic inflammatory papulosquamous disorder with a variable clinical spectrum affecting about 0.5% to 2% of children and adolescence. In spite of all performed researches around the world for seeking better treatments with fewer adverse effects to control the disease, there is still no cure for psoriasis. Treatment of psoriasis in children is very conservative and many therapies used for adults may not be appropriate for children due to possible long-term or delayed adverse effects. A wide range of therapeutic options are existed including; topical therapy, phototherapy, chemotherapy, systemic therapies and biologic therapies. Here in, because of the lack of data in this specific field of dermatology, we decided to review the current therapies of childhood psoriasis.

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Safety of Systemic Agents for the Treatment of Pediatric Psoriasis

et al. 2017

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IMPORTANCE Use of systemic therapies for moderate to severe psoriasis in children is increasing, but comparative data on their use and toxicities are limited.OBJECTIVE To assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in children. DESIGN, SETTING, AND PARTICIPANTSA retrospective review was conducted at 20 centers in North America and Europe, and included all consecutive children with moderate to severe psoriasis who used systemic medications or phototherapy for at least 3 months from December 1, 1990, to September 16, 2014. MAIN OUTCOMES AND MEASURESThe minimal core data set included age, sex, severity of psoriasis, systemic interventions, monitoring, adverse events (AEs), and reason for discontinuation.RESULTS For 390 children (203 girls and 187 boys; mean [SD] age at diagnosis, 8.4 [3.7] years) with psoriasis who used 1 or more systemic medications, the mean interval between diagnosis and starting systemic therapy was 3.0 years. Methotrexate was used by 270 patients (69.2%), biologic agents (primarily etanercept) by 106 (27.2%), acitretin by 57 (14.6%), cyclosporine by 30 (7.7%), fumaric acid esters by 19 (4.9%), and more than 1 medication was used by 73 (18.7%). Of 270 children taking methotrexate, 130 (48.1%) reported 1 or more AEs associated with methotrexate, primarily gastrointestinal (67 [24.8%]). Folic acid 6 days per week (odds ratio, 0.16; 95% CI, 0.06-0.41; P < .001) or 7 days per week (OR, 0.21; 95% CI, 0.08-0.58; P = .003) protected against gastrointestinal AEs more than once-weekly folic acid, regardless of the total weekly dosage. Methotrexate-associated hepatic transaminase elevations were associated with obesity (35 of 270 patients [13.0%]), but a folic acid regimen was not. Injection site reactions occurred in 20 of 106 patients (18.9%) treated with tumor necrosis factor inhibitors, but did not lead to discontinuation of treatment. Having 1 or more AEs related to medication, gastrointestinal AE, laboratory abnormality, or AE leading to discontinuation of the drug was more likely with methotrexate than tumor necrosis factor inhibitors, but having 1 or more infections related to medication (predominantly upper airway) was less likely. Six patients developed a serious treatment-related AE (methotrexate, 3; fumaric acid esters, 2; and adalimumab, 1), but methotrexate and biologic agents were taken for a mean duration that was 2-fold greater than the mean duration for cyclosporine or fumaric acid esters. No patient developed tuberculosis or a malignant neoplasm.CONCLUSIONS AND RELEVANCE Medication-related AEs occur less often with tumor necrosis factor inhibitors than with methotrexate. Folic acid administration 6 or 7 times per week protected more against methotrexate-induced gastrointestinal AEs than did weekly administration. A prospective registry is needed to track the long-term risks of systemic agents for pediatric psoriasis.

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Efficacy and safety of treatments for childhood psoriasis: A systematic literature review

Cited by 126 publications

References 115 publications

The Retrospective Evaluation of Childhood Psoriasis Clinically and Demographic Features

The Retrospective Evaluation of Childhood Psoriasis Clinically and Demographic Features

Management of Psoriasis in Children: a Narrative Review

Safety of Systemic Agents for the Treatment of Pediatric Psoriasis

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