Efficacy and safety of oral Panax notoginseng saponins for unstable angina patients: A meta-analysis and systematic review

Duan, Lian; Xiong, Xingjiang; Hu, Junyuan; Liu, Yongmei; Wang, Jie

doi:10.1016/j.phymed.2018.04.044

Cited by 30 publications

(35 citation statements)

References 23 publications

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“…Several TCM prescriptions are proved to have good clinical effect for the treatment of UAP, and Shexiang Baoxin Pills (SBP) is one of the most promising prescription. [7–10] SBP consists of 7 herbal medicine, namely, musk ( Moschus , She Xiang), ginseng root ( Radix Ginseng , Ren Shen), cow bezoar ( Calculus bovis , Niu Huang), storax ( Styrax , Su He Xiang), cassia bark ( Cortex Cinnamomi , Rou Gui), toad venom ( Venenum Bufonis , Chan Su), and borneol ( Borneolum syntheticum , Bing Pian). [3] The major active components of SBP includes ginsenosides, bile acids, bufadienolides, and volatiles.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Shexiang Baoxin Pills for the treatment of unstable angina pectoris

Chen

Dong²,

Zheng³

2019

Medicine

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Background:Shexiang Baoxin Pills (SBP) is widely used for the treatment of unstable angina pectoris (UAP) in China. However, the clinical evidence on the efficacy of SBP for the treatment of UAP is not well concluded.Methods:Seven electronic databases will be searched for eligible studies: MEDLINE, EMBASE, The Cochrane Library, Wanfang database, Chinese National Knowledge Infrastructure database, VIP database, and Chinese Biological and Medicine database. Data of included studies will be extracted, and quality will be evaluated. Data synthesis will be performed using RevMan software. Subgroup analysis and sensitivity analysis will also be carried out. Publication bias will be evaluated using funnel plot if included studies are sufficient.Results:This systemic review and meta-analysis will provide synthesized result of clinical efficacy of SBP for the treatment of UAP.Conclusions:This systemic review and meta-analysis will provide high-quality evidence on the clinical efficacy of SBP for the treatment of UAP.Registration:PEROSPERO CRD42019124668

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Section: Introductionmentioning

confidence: 99%

Efficacy of Shexiang Baoxin Pills for the treatment of unstable angina pectoris

Chen

Dong²,

Zheng³

2019

Medicine

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“…Data were analysed using the Review Manager 5.3.0 statistical package (Cochrane Collaboration Software). For continuous variables, mean and SD were obtained from each study and pooled as mean difference (MD) (Duan et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Panax notoginseng preparations as adjuvant therapy for diabetic kidney disease: a systematic review and meta-analysis

Tang

Huang

Jiang

et al. 2020

Pharmaceutical Biology

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Context: Panax notoginseng (Burk.) F.H. Chen (Araliaceae) preparations (PNP) are traditional Chinese medicines used as adjuvant therapeutics for diabetic kidney disease (DKD). Objective: To systematically review the efficacy of PNP as adjunct DKD therapy, including their effects on kidney function, serum lipid levels and fasting blood glucose levels. Methods: The databases PubMed, Embase, Medline, Cochrane Library, CINAHL, China Biology Medicine disc, Wanfang, VIP and China National Knowledge Infrastructure were systematically searched from the date of their inception until May 2019. Panax notoginseng, Panax notoginseng saponins, Lulutong, Xueshuantong and Xuesaitong were the key terms searched. Randomized controlled trials (RCTs) comparing the combined use of PNP and conventional medicines (CM) versus CM for DKD were included. Data were pooled using random or fixed effect models depending on heterogeneity. Results: In total, 24 RCTs involving 1918 participants were analysed. Adjunct PNP with CM was associated with reduction of albuminuria (MD-26.89 mg, 95% CI:-33.35 to-20.42), proteinuria (MD-0.32 g/24 h, 95% CI:-0.36 to-0.27), serum creatinine (MD-4.52 lmol/L, 95% CI:-8.71 to-0.32), total cholesterol (MD-1.56 mmol/L, 95% CI:-2.33 to-0.78), triglycerides (TG) (MD-0.56 mmol/L, 95% CI:-0.80 to-0.31) and low-density lipoprotein cholesterol (MD-0.94 mmol/L, 95% CI:-1.49 to-0.40) compared with CM. Conclusions: This is the first meta-analysis investigating adjuvant PNP therapy for DKD. PNP apparently exerted beneficial effects on kidney function and improved the metabolism of serum lipids by CM. Further, well-conducted, high-quality trials on DKD patients are needed to provide high-quality evidence.

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“…Panax notoginseng has been widely used as traditional Chinese medicine for a long history. Saponins are one of the main effective components of panax notoginseng [20,21]. PNS can inhibits adhesion events by the NF-E2-related factor 2 (Nrf2) -p38 -sVCAM1 pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Third-generation cells were selected for the experiment. Panax notoginseng saponins (PNS), the main bioactive components of a traditional Chinese medicinal herb Panax notoginseng, are used for promoting blood circulation and removing blood stasis [20,21,22]. The main mechanisms of PNS function include inhibiting in ammatory cytokines and improving hypoxia [23,24].…”

Section: Culturing Huvecs With Conditioned Medium From Hmcsmentioning

confidence: 99%

Circulating IgA1 Complex Induces Endothelial Injury through Mesangial Cell Activation in IgA Nephropathy

Huang

Zhao

et al. 2020

Preprint

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Background: Renal arteriolar microangiopathic (MA) lesions were common in IgA nephropathy (IgAN) and their presence was an independent risk factor for kidney failure. Endothelial injury is regarded as the most important cause of MA lesions. The deposition of circulating IgA1 complex (cIgA1) in the glomerular mesangium has been regarded as the most important mechanism to induce the injury of podocyte and tubular epithelium. Whether cIgA1 can induce vascular endothelial injury is not clear.Methods: Blood of 59 IgAN patients and 19 healthy controls was collected, pending the measurement of Willebrand factor (vWF) and soluble vascular cell adhesion molecule 1 (sVCAM1) and Heparin-binding EGF-like growth factor (HB-EGF) by ELISA. cIgA1 was isolated from 12 primary IgAN patients who had not been treated with steroids or immunosuppressants and 10 healthy controls. Then, IgA-HMC medium (IgA-HMCM) was prepared by collecting the cell culture supernatants of growth-arrested HMCs grown in medium containing cIgA1. Human umbilical vein endothelial cells (HUVECs) were cultured with the IgA-HMCM in the presence or absence of Panax notoginseng saponins (PNS), which are anti-inflammatory bioactive components of the Chinese medicinal herb Panax notoginseng. The protein levels of interleukin-6 (IL-6) and chemokine (C-X-C motif) ligand 1 (CXCL1) in IgA-HMCM and vWF, sVCAM1 and HB-EGF in HUVEC medium were determined by ELISA. Results: IgAN patients had higher levels of vWF, sVCAM-1 and HB-EGF than that in healthy controls. cIgA1 from IgAN patients (IgAN-cIgA1) induced significantly higher expression levels of IL-6 and CXCL1 in HMCM than cIgA1 from healthy controls. vWF, sVCAM1 and HB-EGF levels induced by conditioned IgAN-cIgA1-treated HMCM (IgAN-HMCM) were significantly higher than the levels induced by conditioned cIgA1-treated HMCM from healthy controls (HC-HMCM). After HUVECs were cultured in PNS and IgAN-HMCM, the levels of vWF, sVCAM1 and HB-EGF were significantly lower in the culture supernatants of cells cultured in PNS and IgAN-HMCM than in that of cells cultured in IgAN-HMCM alone. Conclusion: cIgA1 could activate mesangial cells and, in turn, induce the injury of endothelial cells by inflammation factors in vitro.

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Efficacy and safety of oral Panax notoginseng saponins for unstable angina patients: A meta-analysis and systematic review

Cited by 30 publications

References 23 publications

Efficacy of Shexiang Baoxin Pills for the treatment of unstable angina pectoris

Efficacy of Shexiang Baoxin Pills for the treatment of unstable angina pectoris

Panax notoginseng preparations as adjuvant therapy for diabetic kidney disease: a systematic review and meta-analysis

Circulating IgA1 Complex Induces Endothelial Injury through Mesangial Cell Activation in IgA Nephropathy

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