Efficacy of Shexiang Baoxin Pills for the treatment of unstable angina pectoris

Chen, Huadong; Dong, Qianqian; Zheng, Xiang

doi:10.1097/md.0000000000017119

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…It was found that the total effective rates of angina pectoris and echocardiogram in observation were 96.1% and 93.2%, respectively, both of which were obviously higher than Ctrl (P < 0.05). It was in line with the results of Chen et al [22], indicating that the clinical treatment of Shexiang Baoxin pills can obviously improve the symptoms of angina pectoris and enhance the cardiac function of patients, which was consistent with the results of the previous echocardiographic evaluation.…”

Section: Discussionsupporting

confidence: 92%

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

Gao

Wang

et al. 2021

Journal of Healthcare Engineering

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This paper was aimed to explore the application of the block matching pyramid (BMP) algorithm in echocardiographic spot tracking in patients with coronary heart disease (CHD) and angina pectoris, as well as the effect of Shexiang Baoxin pills (a kind of drug containing musk, which is good for cardiac diseases) on blood lipids, cardiac function, and curative effect. 206 patients with CHD angina pectoris in the hospital from July 2018 to May 2020 were selected as the research subjects and were enrolled into the control (Ctrl) group (conventional treatment, n = 103) and the observation group (the Shexiang Baoxin pill was given on the basis of conventional treatment, n = 103) in random. Then, the patients’ echocardiograms were obtained, and the BMP algorithm was used to track the echocardiograms. At 12 months after treatment, the total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were compared. Besides, the differences between left ventricular end-systolic volume (LVESV), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic volume (LVEDV), left ventricular end-diastolic dimension (LVEDD), cardiac index (CI), cardiac output (CO), and LVEF were observed. Finally, the efficacy of angina pectoris and electrocardiogram was calculated. It was found that the BMP algorithm can track the echocardiograms and display the movement and displacement of the patients’ left ventricle. After treatment, in contrast with the Ctrl, the levels of TC, TG, and LDL-C in the observation group were obviously lower ( P < 0.05 ); the LVESV, LVEDV, and LVEF were obviously lower ( P < 0.05 ), the LVESD, LVEDD, CO, and CI were obviously higher ( P < 0.05 ), the total score of angina after treatment was obviously lower ( P < 0.05 ), and the total effective rates of angina pectoris and echocardiogram were obviously higher ( P < 0.05 ). In conclusion, echocardiographic spot tracking can realize the diagnosis of patients with CHD angina pectoris, and Shexiang Baoxin pill can regulate the blood lipid level and improve the echocardiographic indicators and the clinical efficacy is obvious.

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Section: Discussionsupporting

confidence: 92%

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

Gao

Wang

et al. 2021

Journal of Healthcare Engineering

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“…Besides, Shexiang, also called artificial moschus or musk, is the dried preputial secretion of male Moschus berezovskii Flerov, Moschus sifanicus Przewalski, or Moschus moschiferus Linnaeus. It has the potential to be used for treating the unstable angina pectoris and neurodegenerative diseases [46]. e results of this article showed that approximately 39.53% unigenes of potassium channel toxins were upregulated in the samples of female scorpion, whereas only 16.28% were downregulated.…”

Section: Sex Is One Important Effect Factor In the Erapeuticmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Sex-Biased Gene Expression of Mesobuthus martensii Collected from Gansu Province, China, Reveals Their Different Therapeutic Potentials

Gao

Chen

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The scorpions, named Mesobuthus martensii, commonly called Quanxie (全蝎) in Chinese, have been widely used as one of the animal medicines for more than 1,000 years because of the strong toxicity of their venoms. Meanwhile, scorpions are sexually dimorphic in appearance, and many exhibit traits associated with sex-biased gene expression, including maternal care, mating competition, female mating choices, ecology, and even venom composition and lethality. This study aims to explore the differences in composition of the venom of scorpions of different sex using the method of transcriptomics. Whole de novo transcriptomes were performed on the samples of M. martensii captured from Gansu Province to identify their sex-biased gene expression. The conserved CO-1 sequences of the captured samples matched that of M. martensii. A total of 8,444 (35.15%), 7,636 (31.78%), 8,510 (35.42%), 7,840 (32.63%), 9,980 (41.54%), and 11,829 (49.23%) unigenes were annotated with GO, KEGG, Pfam, Swissprot, eggNOG, and NR databases. Moreover, a total of 43 metalloproteases, 40 potassium channel toxins, 24 phospholipases, 12 defensins, 10 peroxiredoxins, 9 cysteine proteinase inhibitors, 7 serine protease inhibitors, 6 sodium channel toxins, 2 NDBPs, 1 calcium channel toxin, 1 waprin-like peptide, 1 antibacterial peptide, 1 antimicrobial peptide, and 1 anticoagulant peptide were screened out. With the fold change of 2 and 0.5, p value < 0.01, and q value < 0.05 as thresholds, a total of 41 out of 157 (26.11%) toxin-related unigenes had significant differential expression, and this ratio was much higher than the ratio of differentially expressed unigenes out of all annotated ones (8.84%). Of these differentially expressed toxins, 28 were upregulated and occupied the majority, up to 68.30%. The female scorpions showed more upregulated unigenes that annotated with toxins and had the potential to be used as more effective therapeutic drugs. In addition, this method of omics can be further used as a useful way to identify the difference between female and male toxic animals.

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“…Natomiast niestabilna dławica piersiowa (UAP) wchodzi w skład zbioru choroby niedokrwiennej serca i klasyfikowana jest jako ostry zespół wieńcowy. Poprawa leczenia w zakresie profilaktyki pierwotnej i strategii leczenia ostrego doprowadziła do zmniejszenia śmiertelności wewnątrzszpitalnej z powodu niestabilnej dławicy piersiowej, natomiast częstość występowania tego schorzenia nadal jest znaczna, dlatego istnieje duża potrzeba rozwoju nowych terapii leczenia UAP i poszukiwania nowych i bezpiecznych leków [40].…”

Section: Choroba Niedokrwienna Sercaunclassified

Multidirectional pharmacological effects of saponins in light of clinical trials: a systematic review of literature

Adam

Rafał

MATYSEK

et al. 2023

J Educ Health Sport

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Introduction: Saponins are secondary metabolites widely distributed in higher plants with multidirectional pharmacological effects. We distinguish between steroidal and triterpenoidal saponins, which are composed of glycone and aglycone. The varied medicinal properties of saponins are influenced by the presence of different substituents in the polycyclic aglycone, e.g. hydroxyls, hydroxymethyls, carboxyls and acyl groups, as well as the difference in bonding, composition and number of sugar chains. It is noteworthy that foods rich in these compounds can reduce the risk of developing various diseases, and the isolation of these compounds from the plant matrix provides new opportunities to create potential and effective drugs. Purpose of the work: Conduct a literature review on the basis of available clinical studies on the pharmacological effects of saponins extracted from medicinal plants and their potential application in medicine. Materials and methods: The work was based on a literature review of available medical publications from clinical trials conducted for the multidirectional therapeutic effects of saponins. Reports available in publications and scientific studies posted in medical information databases such as Pubmed and Google Scholar were summarised. Results: Clinical studies confirm the pharmacological effect of saponins in the treatment of sports injuries and trauma, type II diabetes, abnormal glycemic state fasting glucose, ischemic heart disease, pancytopenia and aplastic anemia. Conclusions: With the advancement of scientific research on saponins, it is possible to use them to produce potential drugs and dietary supplements with pharmacological effects. However, before saponins can be used for medical treatment, further research on their efficacy and safety is needed.

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Efficacy of Shexiang Baoxin Pills for the treatment of unstable angina pectoris

Cited by 4 publications

References 19 publications

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

Sex-Biased Gene Expression of Mesobuthus martensii Collected from Gansu Province, China, Reveals Their Different Therapeutic Potentials

Multidirectional pharmacological effects of saponins in light of clinical trials: a systematic review of literature

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