Efficacy and Safety of Mechanical Thrombectomy for Acute Mild Ischemic Stroke with Large Vessel Occlusion

Wang, Guifang; Zhao, Xue; Liu, Shuping; Xiao, Yi; Lu, Zuneng

doi:10.12659/msm.926110

Cited by 6 publications

(11 citation statements)

References 29 publications

(25 reference statements)

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“…In mild stroke, defined by initial clinical stroke severity of NIHSS 0–5, two studies found that IVT was not associated with higher rates of sICH ( 99 , 100 ). Two other studies observed no significant association between MT and sICH in cohorts of patients with mild stroke ( 101 , 102 ).…”

Section: Intracranial Bleeding After Reperfusion Therapy: Risk Factormentioning

confidence: 84%

Intracranial Bleeding After Reperfusion Therapy in Acute Ischemic Stroke

et al. 2021

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Intracranial hemorrhage is one of the most feared complications following brain infarct. Ischemic tissues have a natural tendency to bleed. Moreover, the first recanalization trials using intravenous thrombolysis have shown an increase in mild to severe intracranial hemorrhage. Symptomatic intracerebral hemorrhage is strongly associated with poor outcomes and is an important factor in recanalization decisions. Stroke physicians have to weigh the potential benefit of recanalization therapies, first, with different risks of intracranial hemorrhage described in randomized controlled trials, and second with numerous risk markers that have been found to be associated with intracranial hemorrhage in retrospective series. These decisions have become quite complex with different intravenous thrombolytics and mechanical thrombectomy. This review aims to outline some elements of the pathophysiological mechanisms and classifications, describe most of the risk factors identified for each reperfusion therapy, and finally suggest future research directions that could help physicians dealing with these complications.

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Section: Intracranial Bleeding After Reperfusion Therapy: Risk Factormentioning

confidence: 84%

Intracranial Bleeding After Reperfusion Therapy in Acute Ischemic Stroke

et al. 2021

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“…However, these mechanical devices are often associated with vasospasm or vessel wall damage [ 63 ] and the systemic complications are even higher than IV thrombolysis. [ 68 ] In addition, the time used for surgical intervention is a factor that cannot be ignored. Therefore, a more efficient and safe thrombus treatment strategy is still the direction for researchers to explore in the future.…”

Section: Existing Thrombosis Treatment Techniquesmentioning

confidence: 99%

Application of Nanotechnology in Thrombus Therapy

Zhou

Zhao

et al. 2023

Adv Healthcare Materials

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A thrombus is a blood clot that forms in the lumen of an artery or vein, restricting blood flow and causing clinical symptoms. Thrombosis is associated with many life-threatening cardiovascular diseases. However, current clinical therapeutic technologies still have many problems in targeting, enrichment, penetration, and safety to meet the thrombosis treatment needs. Therefore, researchers devote themselves to developing nanosystems loaded with antithrombotic drugs to address this paradox in recent years. Herein, the existing thrombosis treatment technologies are first reviewed; and then, their advantages and disadvantages are outlined based on a brief discussion of thrombosis's definition and formation mechanism. Furthermore, the need and application cases for introducing nanotechnology are discussed, focusing on thrombus-specific targeted ligand modification technology and microenvironment-triggered responsive drug release technology. Then, nanomaterials that can be used to design antithrombotic nanotherapeutic systems are summarized. Moreover, a variety of drug delivery technologies driven by nanomotors in thrombosis therapy is also introduced. Last of all, a prospective discussion on the future development of nanotechnology for thrombosis therapy is highlighted.

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“…The large-bore aspiration catheter is connected to a source of continuous aspiration, and thrombus aspiration is attempted (Lapergue et al, 2017 ). Although the short-and long-term effects of mechanical thrombectomy are comparable to those of intravenous thrombolysis, it has a higher rate of systemic complications (Wang G. F. et al, 2020 ). And, since mechanical thrombectomy needs to be performed by a qualified neurointerventionist at comprehensive stroke centers, most hospitals remain unqualified to provide treatment.…”

Section: Nanomaterials-based Drug Deliverymentioning

confidence: 99%

Recent Advances in Nanomaterials for Diagnosis, Treatments, and Neurorestoration in Ischemic Stroke

Lin

Tang

2022

Front. Cell. Neurosci.

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Stroke is a major public health issue, corresponding to the second cause of mortality and the first cause of severe disability. Ischemic stroke is the most common type of stroke, accounting for 87% of all strokes, where early detection and clinical intervention are well known to decrease its morbidity and mortality. However, the diagnosis of ischemic stroke has been limited to the late stages, and its therapeutic window is too narrow to provide rational and effective treatment. In addition, clinical thrombolytics suffer from a short half-life, inactivation, allergic reactions, and non-specific tissue targeting. Another problem is the limited ability of current neuroprotective agents to promote recovery of the ischemic brain tissue after stroke, which contributes to the progressive and irreversible nature of ischemic stroke and also the severity of the outcome. Fortunately, because of biomaterials’ inherent biochemical and biophysical properties, including biocompatibility, biodegradability, renewability, nontoxicity, long blood circulation time, and targeting ability. Utilization of them has been pursued as an innovative and promising strategy to tackle these challenges. In this review, special emphasis will be placed on the recent advances in the study of nanomaterials for the diagnosis and therapy of ischemic stroke. Meanwhile, nanomaterials provide much promise for neural tissue salvage and regeneration in brain ischemia, which is also highlighted.

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Efficacy and Safety of Mechanical Thrombectomy for Acute Mild Ischemic Stroke with Large Vessel Occlusion

Cited by 6 publications

References 29 publications

Intracranial Bleeding After Reperfusion Therapy in Acute Ischemic Stroke

Intracranial Bleeding After Reperfusion Therapy in Acute Ischemic Stroke

Application of Nanotechnology in Thrombus Therapy

Recent Advances in Nanomaterials for Diagnosis, Treatments, and Neurorestoration in Ischemic Stroke

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