Efficacy and safety of low‐dose urokinase for the treatment of hemodynamically stable AECOPD patients with acute pulmonary thromboembolism

Jing, Xiaogang; Zhang, Guojun; Zhang, Beifeng; Dai, Lingling; Wang, Xi; Jia, Liting; Wang, Huan; An, L.; Yang, Yuanjian; Cheng, Zhe

doi:10.1111/crj.12751

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…The results showed that the hospitalization time of these patients at 3–6 months after treatment was shorter than that in the conventional treatment group, and the reduction rate of pulmonary artery thrombosis was higher. Jing et al 59 studied 96 patients with hemodynamically stable AECOPD combined with PE and found that low-dose urokinase (500,000 IU/day, 5–7 days) could improve the effective rate of hospitalization and reduce the incidence of adverse events and mean recurrence time within 1 year, but further clinical studies are needed to confirm this. Inferior vena cava filter implantation (IVC) is a good treatment option for high-risk PE patients.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

Pulmonary embolism with chronic obstructive pulmonary disease

Yang

Liu

Deng

2021

Chronic Diseases and Translational Medicine

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Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease. The incidence of COPD is growing annually in China, and it is a significant and growing public health burden. Multivariate analysis showed that COPD was one of the independent risk factors for the occurrence of pulmonary embolism (PE), and the incidence of PE was significantly higher in COPD patients than in normal subjects. However, PE is often overlooked in patients with acute exacerbation of COPD (AECOPD) because there are many similarities in clinical symptoms between PE and AECOPD, which are difficult to distinguish, resulting in the failure of timely treatment and poor prognosis. Therefore, it is of great significance to understand the clinical manifestations, diagnosis, and treatment of COPD combined with PE for making a more accurate diagnosis, providing timely and effective treatment, and improving the prognosis of such patients.

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Section: Diagnosis and Treatmentmentioning

confidence: 99%

Pulmonary embolism with chronic obstructive pulmonary disease

Yang

Liu

Deng

2021

Chronic Diseases and Translational Medicine

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“…AECOPD is a phenomenon whereby patients with COPD have an aggressive airway obstruction, difficulty breathing, and increased sputum in a short amount of time. Patients with AECOPD have a higher rate of infection with respiratory viruses and atypical clinical manifestations; this is especially true for patients over the age of 65 (18,19). Studies by Dr. Jie and his colleagues have examined the pharmacological action of Chinese medicine against influenza.…”

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confidence: 99%