Efficacy and possible mechanisms of botulinum toxin treatment of oily skin

Abstract

Background:Oily skin is one of the most common dermatological complaints. Oily skin may be accompanied by enlarged pores, acne, and seborrheic dermatitis.Moreover, oily skin has negative effects on self-perception. Most therapeutic approaches used to treat oily skin have had varying degrees of efficacy and include topical treatments, such as photodynamic therapy and lasers. However, certain of these therapies for oily skin may lead to severe side effects. With the expanding use and high safety profile of botulinum toxin type A (BoNT-A), its use in the treatment of oily skin has caused significant concerns; moreover, relevant reports have gradually accumulated to address the efficacy of BoNT-A and explore its mechanisms of action. Aims:The objective of this article was to review the efficacy and possible treatment mechanisms of BoNT-A on oily skin. Methods:A retrospective review of the published data was conducted. Results:Most studies have suggested that the intradermal injection of BoNT-A decreased sebum production and pore size. Furthermore, this treatment attained high patient satisfaction without significant side effects. BoNT-A effectively decreased sebum production and excretion, which was in keeping with previous studies, possibly via its blockade of cholinergic signaling and its neuromodulatory effects. Conclusions: Intradermal BoNT-A injection may represent a promising new treat-ment for oily skin and other relevant dermatological problems, such as enlarged pores, acne, and seborrheic dermatitis. Further study is still needed to determine the specific mechanisms of BoNT-A and the optimal injection techniques and doses for oily skin and other relevant cosmetic concerns. K E Y W O R D S efficacy, oily skin, sebaceous gland, sebum, toxin 452 | SHUO et al. sebum secretion can lead to an array of cosmetic problems, such as acne and seborrheic dermatitis. Oily skin has negative effects on self-perception, as well as detrimental psychosocial consequences. Many people with this condition feel embarrassed, frustrated, and unattractive. 3 Most therapeutic approaches, which have been used to treat oily skin, have varying degrees of efficacy. 4 Recently, the use of BoNT-A on oily skin has caused significant concerns; however, relevant reports have gradually accumulated to address the efficacy of BoNT-A and explore its mechanisms of action. The objective of this article was to review the efficacy and possible treatment mechanisms of botulinum toxin on oily skin. | MATERIAL S AND ME THODS | Search strategyWe performed a systematic search of the Cochrane Library, EMBASE, Pubmed, Web of Science, and SCOPUS. The following key words and/or corresponding Medical Subject Heading terms were used: botox or botulinum toxin or botulin or botulinus toxin; and sebum or seborrhea or oily; and glandula sebacea or sebaceous gland; and efficacy or mechanisms.A systematic search of the Cochrane Library, EMBASE, Pubmed, Web of Science, and SCOPUS was performed by two investigators to identify all the related studies. No restrictions we...

The anti‐sebum property of chitosan particles

“…No standardized approaches nor agents have proven effective for the treatment of seborrhea. Current available treatments that can reduce sebum include topical drugs, systemic treatments, botulinum toxin injection, and phototherapy . Exact mechanisms of action of some treatments are still unclear, but various mechanisms have been proposed, with ultimate outcomes being sebosuppression via reducing sebocyte proliferation, differentiation, and apoptosis .…”

Intradermal Microdroplet Injection of Diluted Incobotulinumtoxin-A for Sebum Control, Face Lifting, and Pore Size Improvement

“…5 More recently, intradermal injection of BTX has been used off-label for various aesthetic conditions, including facial skin laxity, excess sebum production, and enlarged facial pores. [8][9][10][11][12][13] These effects could be attributed to the paralysis of arrector pili muscles or decreased sebum production via acetylcholine inhibition. 10,13,14 However, previous studies relied on subjective evaluation and lacked long-term clinical data.…”

Oily sensitive skin: A review of management options

“…Intradermal injection of botulinum toxin is suggested as a new strategy for treating excessive sebum and enlarged pores . Rose et al reported that botulinum toxin treatment decreases sebum production to 80% after 1 month, which is comparable with the reported sebum reduction by oral isotretinoin (60%‐90%) .…”

“…It is usually accompanied by enlarged pores, acne, and seborrheic dermatitis. Moreover, oily skin has negative effects on self‐perception . Meanwhile, sensitive skin is described as a condition of subjective hyper‐reactivity to exogenous factors.…”