Efficacy and Kinetics of Carprofen, Administered Preoperatively or Postoperatively, for the Prevention of Pain in Dogs Undergoing Ovariohysterectomy

Lascelles, B. Duncan X.; Cripps, Peter; Jones, Alan J.; Waterman-Pearson, AE

doi:10.1111/j.1532-950x.1998.tb00533.x

Cited by 196 publications

(201 citation statements)

References 38 publications

(2 reference statements)

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“…Arterial blood pressure should be monitored and maintained within a normal range during anesthesia when carprofen or meloxicam are administered with butorphanol as premedication for dogs. Both clinical doses of carprofen and meloxicam provide effective postoperative analgesia when preoperatively administered [17][18][19], although meloxicam has higher in vitro selectivity of COX-2 inhibition than carprofen in dogs [5,15]. We also did not find any difference in sevofluranesparing effect between the treatments with carprofen alone and meloxicam alone, and between carprofen with butorphanol and meloxicam with butorphanol in dogs.…”

Section: Discussionmentioning

confidence: 47%

“…Carprofen and meloxicam are COX-2 selective inhibitors that have been shown to produce analgesic effects with minimal side effect in dogs [5,6,15,34]. Their preoperative administration to dogs undergoing ovariohysterectomy has been reported to produce a greater analgesic effect in the early postoperative period than does postoperative administration [18,19]. Also carprofen and meloxicam have been reported to relieve signs of pain for up to 24 hr in dogs undergoing orthopaedic surgery [7,17].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Yamashita

Okano

Yamashita

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. Sparing effects of carprofen and meloxicam with or without butorphanol on the minimum alveolar concentration (MAC) of sevoflurane were determined in 6 dogs. Anesthesia was induced and maintained with sevoflurane in oxygen, and MAC was determined by use of a tail clamp method. The dogs were administered a subcutaneous injection of carprofen (4 mg/kg) or meloxicam (0.2 mg/kg), or no medication (control) one hour prior to induction of anesthesia. Following the initial determination of MAC, butorphanol (0.3 mg/ kg) was administered intramuscularly, and MAC was determined again. The sevoflurane MACs for carprofen alone (2.10 ± 0.26%) and meloxicam alone (2.06 ± 0.20%) were significantly less than the control (2.39 ± 0.26%). The sevoflurane MACs for the combination of carprofen with butorphanol (1.78 ± 0.20%) and meloxicam with butorphanol (1.66 ± 0.29%) were also significantly less than the control value after the administration of butorphanol (2.12 ± 0.28%). The sevoflurane sparing effects of the combinations of carprofen with butorphanol and meloxicam with butorphanol were additive.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Yamashita

Okano

Yamashita

et al. 2008

The Journal of Veterinary Medical Science

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“…Preoperative administration in dogs is superior in efficacy to postoperative use, consistent with results of multiple studies performed in humans. 32 Similar studies have not been conducted in cats undergoing anesthesia, but one feline study revealed no alteration in glomerular filtration rate measured by iohexol clearance after 5 days of oral meloxicam. 27 if iV access is not possible and normotension cannot be achieved with certainty, the Task Force recommends limiting the use of NSAiDs to postsurgical administration.…”

Section: Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 97%

2015 AAHA/AAFP Pain Management Guidelines for Dogs and Cats

Epstein¹,

Rodan²,

Griffenhagen

et al. 2015

Journal of Feline Medicine and Surgery

195

143

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“…These simple scales are subjective, and are only widely used because of their simplicity 33 . A number of composite pain assessment scales have been developed from the three basic ones mentioned above, for example, the 'dynamic' and 'interactive' visual assessment scale (DIVAS) used in a study of the analgesic efficacy of carprofen in dogs 21 and the validated Glasgow Composite Pain Tool 14 . A composite scale modified from the University of Melbourne Pain Scale and the Glasgow Composite Pain Tool was used for assessment of pain in this study.…”

Section: Introductionmentioning

confidence: 99%

Comparison of morphine and carprofen administered alone or in combination for analgesia in dogs undergoing ovariohysterectomy

Dzikiti¹,

Joubert²,

Venter³

et al. 2006

J. S. Afr. Vet. Assoc.

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In this study the analgesic efficacy of the pure agonistic opioid morphine and the cyclo-oxygenase type-2-selective carprofen were compared since there is no previous specific comparative study for these two common analgesics. Forty-five bitches undergoing elective ovariohysterectomy were randomly assigned to one of three groups; receiving morphine 0.4 mg/kg bodyweight pre-operatively and 0.2 mg/kg every 4-6 hours thereafter (Morphine group), receiving a once-off carprofen 4 mg/kg injection (Carprofen group) or receiving both morphine and carprofen (MorphCarp group). The dogs were premedicated with acepromazine 0.01 mg/kg and induced with either thiopentone 5-10 mg/kg or propofol 4-6 mg/kg. General anaesthesia was maintained with halothane in oxygen. The degree of pain was assessed over a 24-hour period under blinded conditions using a pain scale modified from the University of Melbourne pain scale and the Glasgow composite pain tool. Physiological parameters such as respiratory rate, pulse rate and body temperature were also assessed over the same time period. There was no significant difference in pain-scores and thus analgesia offered by the three analgesia protocols at any assessment point across the three groups, but there were differences within groups across time points. Baseline total pain-scores were lower than scores at all post-operative points within all three groups. Both morphine and carprofen provided good analgesia without any obvious adverse effects. This study indicates that at the dosages indicated above, carprofen administered on its own produces analgesia equal to that produced by morphine and that the two drugs administered together do not produce better analgesia than either drug administered on its own.

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Efficacy and Kinetics of Carprofen, Administered Preoperatively or Postoperatively, for the Prevention of Pain in Dogs Undergoing Ovariohysterectomy

Abstract: Carprofen provides effective analgesia after canine ovariohysterectomy. The timing of analgesic administration is important to optimize the control of postoperative pain.

Cited by 196 publications

References 38 publications

Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

2015 AAHA/AAFP Pain Management Guidelines for Dogs and Cats

Comparison of morphine and carprofen administered alone or in combination for analgesia in dogs undergoing ovariohysterectomy

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