Effets antimicrobiens, anti-inflammatoires et antioxydants du mésocarpe de Garcinia kola Heckel (Clusiaceae)

Morabandza, Cyr Jonas; Okemy, A. N.; Ongoka, R. P.; Okiemy-Akieli, M. G.; Attibayeba, A.; Abena, Ange Antoine

doi:10.1007/s10298-014-0862-6

Cited by 4 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In view of this principle, the aqueous extract of G. kola has a bactericidal effect on all the strains studied. Our results corroborate those of [21]. These authors have indicated that the aqueous extract of G. kola mesocarp has a bactericidal effect on S. aureus strains.…”

Section: Discussionsupporting

confidence: 92%

“…This indicates that the aqueous extract of G. kola has better antibacterial activity than oxacillin. This bactericidal effect of the aqueous extract of G. kola could be explained by the presence of secondary metabolites found therein namely alkaloids, anthraquinones, flavonoids, saponosides, tannins, terpenes and steroids [21]. Studies have shown that flavonoids are good inhibitors of the sortases, enzymes found in the cytoplasmic membrane of Gram-positive bacteria that catalyze all surface proteins (adhesins and internalins) [22].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Staphylococcal Activity of Garcinia kola Almonds

Karamoko

Didier

Monon

et al. 2019

IJBcRR

View full text Add to dashboard Cite

The emergence of infectious diseases, particularly staphylococcal infections, treatment failures and the more high cost of treatment of infections caused by resistant staphylococci called to find other care alternatives. This study was initiated to evaluate the antibacterial activity of the aqueous extract from Garcinia kola almonds on the in vitro growth of Staphylococcus aureus strains. The methods of diffusion in agar and liquid media were used for susceptibility testing and MIC and MBC determination. The tests were performed on four strains of S. aureus and one reference strain. The minimum inhibitory concentrations of the extracts ranged from 3.12 mg/mL and 12.5 mg/mL and the minimum bactericidal concentrations between 6.25 mg/mL and 25 mg/mL. The lowest value of MIC and MBC was observed with S. aureus ATCC 29213 while the greatest value of these same parameters was obtained on S. aureus 993C/18 and S. aureus 1075C/18. The aqueous almonds extract of Garcinia kola had a bactericidal activity on all the strains of S. aureus studied. This could justify the use of Garcinia kola almonds in the treatment of various diseases in traditional society.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Evaluation of Staphylococcal Activity of Garcinia kola Almonds

Karamoko

Didier

Monon

et al. 2019

IJBcRR

View full text Add to dashboard Cite

show abstract

“…This testifies to the seriousness which presided over their formulation. The absence of microorganisms confirms the antibacterial power of Garcinia kola nuts as reported by Morabandza et al in 2014 [14].…”

Section: Discussionsupporting

confidence: 84%

Evaluation of the anti-inflammatory activity of Garcinia kola capsules on Gonarthrosis and low back pain

Nathalie¹,

Djoko²,

Madeleine³

2022

Int. J. Biol. Pharm. Sci. Arch.

View full text Add to dashboard Cite

Garcinia kola (Clusiaceae) commonly known as "Bitter cola", is a shrub from the forests of Central and East Africa. In Cameroon it is found in Mbam and Moungo divisions. Garcinia kola seeds are widely consumed by local populations, sometimes in search of a simple pleasure, sometimes in search of its multiple pharmacological properties. The main objective of this study was to evaluate the anti-inflammatory activity and the tolerance of Garcinia kola capsules (BTK capsules *) on gonarthrosis and lumbago. A pilot study was carried out on 90 patients (68 women and 22 men). The patients were divided into 3 groups. Patients in the first group received Garcinia kola capsules at a dose of 800 mg per day while those in the second group received Diclofenac tablets at a dose of 100 mg per day and those in the third group received placebo capsules. The judgement criteria were highly sensitive C Reactiv Protein (HS-CRP), sedimentation rate (SR), visual analogue scale (VAS). The test significance threshold was set at a probability of p ˂ 0.05. The first group (Garcinia kola) showed: HS-CRP p ˂ 0.002, VAS p ˂ 0.001 and SR: p ˂ 0.003; the second group (Diclofenac): HS-CRP p = 0.001, VAS p ˂ 0.001 and SR p ˂ 0.001. For the placebo group: HS-CRP p = 0.916, VAS p = 0.002 and SR p = 0.829. These results confirm that Garcinia kola at a dose of 400 mg twice a day has anti-inflammatory properties similar to those of Diclofenac at 50 mg twice a day. Biological tests revealed that Garcinia kola (BTK *) capsules have no harmful effects on kidney function, liver function, blood sugar and blood pressure. Libido was increased in men.

show abstract

“…These results contrast those found by Akoachere et al, 2002 [21] who had noted an MIC between (1µg/mL and 1.8µg/mL) on S. aureus. Also those reported by Morabandza et al, who found an MIC of 9mg/mL [23]. This difference could be explained by the geographical distribution of the…”

Section: Discussionmentioning

confidence: 79%

<i>In vitro</i> Antioxidant, Anti-inflammatory and Antimicrobial Activities of <i>Garcinia kola</i> Seeds (Clusiaceae)

Dermane¹,

Gbati²,

Bakoma³

2021

IJPC

View full text Add to dashboard Cite

The use of plants in health promotion is increasingly noteworthy in the face of the re-emergence of diseases and the limitation of conventional drugs. Garcinia kola (Clusiceae) is used in traditional medicine in Togo. The seeds, very used, are renowned for their anti-infective and antioxidant properties. The objective of this study was to contribute to the valuation of Garcinia kola through the determination of its phytochemical groups and the evaluation of some of its biological activities. The supernatant was obtained by maceration ethanol/water (80/20) of powder from the seeds after separation. The phytochemical screening was carried out by staining and precipitation test. Antioxidant activity was determined by DPPH and FRAP test. Assessment of anti-inflammatory activity was performed by test of denaturation of bovine serum albumin protein (BSA) and denaturation of egg albumin protein (EA). The evaluation of the antibacterial activity of the extract was carried out by the agar diffusion and micro dilution method. The antibacterial effect was assessed by the MBC/MIC ratio. The phytochemical screening revealed the presence of flavonoids, alkaloids, tannins, phenolic compounds, triterpenes, sterols and cardiotonic heterosides. The extract has shown an important antioxidant and anti-free radical activity concomitantly with its phytochemical makeup. The anti-inflammatory test, meanwhile, showed the ability of the extract to inhibit protein denaturation. Furthermore, antibacterial test revealed that the supernatant has activity on Staphylococcus aureus ATCC 29213 (MIC=3.125mg/mL). The result showed that the seeds of Garcinia kola have antioxidant, anti-inflammatory and antibacterial activities, which would justify phytodrug research.

show abstract

Effets antimicrobiens, anti-inflammatoires et antioxydants du mésocarpe de Garcinia kola Heckel (Clusiaceae)

Cited by 4 publications

References 11 publications

Evaluation of Staphylococcal Activity of Garcinia kola Almonds

Evaluation of Staphylococcal Activity of Garcinia kola Almonds

Evaluation of the anti-inflammatory activity of Garcinia kola capsules on Gonarthrosis and low back pain

<i>In vitro</i> Antioxidant, Anti-inflammatory and Antimicrobial Activities of <i>Garcinia kola</i> Seeds (Clusiaceae)

Contact Info

Product

Resources

About

Effets antimicrobiens, anti-inflammatoires et antioxydants du mésocarpe de Garcinia kola Heckel (Clusiaceae)

Cited by 4 publications

References 11 publications

Evaluation of Staphylococcal Activity of Garcinia kola Almonds

Evaluation of Staphylococcal Activity of Garcinia kola Almonds

Evaluation of the anti-inflammatory activity of Garcinia kola capsules on Gonarthrosis and low back pain

&lt;i&gt;In vitro&lt;/i&gt; Antioxidant, Anti-inflammatory and Antimicrobial Activities of &lt;i&gt;Garcinia kola&lt;/i&gt; Seeds (Clusiaceae)

Contact Info

Product

Resources

About

<i>In vitro</i> Antioxidant, Anti-inflammatory and Antimicrobial Activities of <i>Garcinia kola</i> Seeds (Clusiaceae)