Effects on the peripheral nervous system of tunnel workers exposed to acrylamide and N-methylolacrylamide

Differences in hemoglobin adduct levels of acrylamide in the general population with respect to dietary intake, smoking habits and gender

“…All previous data on the background level of the Hb adduct from AA [12][13][14][15][45][46], except for the study by Schettgen et al [47], came from the same laboratory as in the present study, using the same instruments and standards for quantification etc. In these published studies of altogether about 50 non-smoking individuals the adduct level varies between 0.02 and 0.07 nmol/g Hb.…”

“…Exposure to AA in work environments has been studied by measurements of stable reaction products (adducts) to hemoglobin (Hb), as a measure of internal dose [11][12][13][14][15]. In exposed workers dose-response relationships between Hb adducts and neurotoxic effects have been demonstrated [14,16].…”

Self-reported symptoms and neuropsychological function among tunnel workers previously exposed to acrylamide and N-methylolacryl­amide

“…Acute neurotoxic effects were seen among Swedish workers in a tunnel construction project where NMA-based grouts were used (9). We have previously reported possible genotoxic (10) and neuro toxic (11) effects among Norwegian tunnel workers using NMAbased grouts. Among the Norwegian tunnel workers, we found indications of reversibility of several symptoms, such as skin-irritat ion, pares thesia, and pain in the hands when the workers were examined 16 months postexposure (11).…”

Chromosome aberrations in tunnel workers exposed to acrylamide and N-methylolacrylamide

“…Twenty of the twenty-five exposed workers reported direct skin contact with acrylamide grout, while all of the exposed workers stated that they had skin contact with tunnel water. Further details of the exposure conditions in the tunnel have been presented elsewhere (7,18).…”

“…We have recently reported nervous system effects in 25 of the workers exposed to acrylamide and N-methylolacrylamide during this grouting work (7). The aim of the present study was to examine possible genotoxic effects in tunnel workers with relevant exposure to acrylamide-containing grout during a 2-year period.…”