Differences in hemoglobin adduct levels of acrylamide in the general population with respect to dietary intake, smoking habits and gender

Hagmar, Lars; Wirfält, Elisabet; Paulsson, Birgit; Törnqvist, Margareta

doi:10.1016/j.mrgentox.2004.11.008

Cited by 95 publications

(74 citation statements)

References 45 publications

(72 reference statements)

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“…Hagmar et al (2005)). Adducts to N-terminal valines were measured using the N-alkyl Edman method (Törnqvist et al, 1986) with modifications for measurement of AA adducts as described by Bergmark (1997).…”

Section: Biobankmentioning

confidence: 99%

“…Individuals (n ¼ 142) were selected on the basis of a dietary history methodology to obtain the highest possible variation in the dietary exposure of AA. The internal dose of AA in non-smokers (n ¼ 70) was shown to vary by a factor up to five (Hagmar et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…The risk figures indicate that the absolute cancer risk associated with dietary AA is not negligible for the population, although the cancer risk is low for the individual (Hagmar et al, 2005). Epidemiological studies have estimated the dietary AA intakes by combining published data on AA content in foods and self-reported data on dietary habits, and examined the cancer risk at various sites associated with the estimated AA intakes (Mucci et al, 2003(Mucci et al, , 2004(Mucci et al, , 2005(Mucci et al, , 2006Pelucchi et al, 2003Pelucchi et al, , 2004, but none of these studies have indicated increased cancer risks associated with AA intakes.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, it is not clear if the intake estimates of AA in published studies are valid reflections of the true dietary exposures. To our knowledge, only a couple of attempts have been made to compare the accuracy of the estimated dietary AA intakes against objective markers of AA exposure (Hagmar et al, 2005;Kütting et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…The Malmö Diet and Cancer (MDC) is a large population-based prospective cohort study in the south of Sweden (Berglund et al, 1993). We have in a previous study (Hagmar et al, 2005) described the variation in AA adduct levels in Hb, by examining erythrocyte samples from the biobank of the MDC cohort. Individuals (n ¼ 142) were selected on the basis of a dietary history methodology to obtain the highest possible variation in the dietary exposure of AA.…”

Section: Introductionmentioning

confidence: 99%

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Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmö Diet and Cancer cohort

et al. 2007

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Objective: To examine the coherence of estimated intakes of acrylamide (AA) from foods, with hemoglobin (Hb) AA adduct levels, an objective marker of environmental AA exposure. Design: A cross-sectional study. Setting: The Malmö Diet and Cancer study, a large population-based prospective cohort (n ¼ 28 098) in the south of Sweden. Subjects: A sample of non-smoking (n ¼ 70) and smoking (n ¼ 72) women and men selected to obtain large variation in Hb AA adducts. Methods: Self-reported data on the usual consumption of foods were combined with published data on the AA content in Swedish foods. The Hb AA adduct levels were determined by a modified Edman degradation method. Linear regression and correlation analysis examined associations between estimated AA intakes, and Hb AA adducts. Results: In randomly selected individuals (n ¼ 40), the estimated median AA intake was 28 mg per day. In linear regression models, adjusting for sex, significant associations were seen in non-smokers between Hb AA adducts and estimated AA from foods (P ¼ 0.006). In smokers both AA from foods (P ¼ 0.006) and the calculated amount of tobacco consumed (P ¼ 0.003) were significantly associated with Hb AA adducts. Positive partial correlations between dietary AA estimates and Hb AA adducts were seen in smoking men (r ¼ 0.37) and women (r ¼ 0.59), and in non-smoking men (r ¼ 0.60), but not in non-smoking women. Conclusions: This study suggests that both diet and tobacco are important sources of the environmental AA exposure, although the lack of correlations in non-smoking women cast doubt on the validity of dietary AA intake estimates used in cancer epidemiology, or suggest that unrecognized factors may influence the internal dose measure of AA exposure.

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Section: Biobankmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmö Diet and Cancer cohort

et al. 2007

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Addendum zu Acrylamid [BAT Value Documentation in German language, 2012]

Göen¹

2013

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Biologische Arbeitsstoff‐Toleranz‐Werte (BAT‐Werte), Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA), Biologische Leitwerte (BLW) und Biologische Arbeitsstoff‐Referenzwerte (BAR) , 17. Lieferung, Ausgabe 2012 Der Artikel enthält folgende Kapitel: Auswahl der Indikatoren und Untersuchungsmaterialien Belastung und Beanspruchung Untersuchungsmethoden Hintergrundbelastung Addukte Merkaptursäuren im Urin Evaluierung Evaluierung der Biologischen Arbeitsstoff‐Referenzwerte (BAR) Evaluierung der EKA‐Korrelation Reevaluierung des Biologischen Leitwertes (BLW) Interpretation

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N‐(2‐Carbamoylethyl)valin – Hämoglobin‐Addukt von Acrylamid [Biomonitoring Methods in German language, 2010]

Bader¹

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material , 19. Lieferung, Ausgabe 2010 Der Artikel enthält folgende Kapitel: Grundlage des Verfahrens Geräte, Chemikalien und Lösungen Geräte Chemikalien Lösungen Vergleichsstandards Probenahme und Probenvorbereitung Gewinnung des Erythrocytenhämolysats Isolierung des Globins Modifizierter Edman‐Abbau Instrumentelle Arbeitsbedingungen Gaschromatographische Arbeitsbedingungen Massenspektrometrische Arbeitsbedingungen Analytische Bestimmung Kalibrierung Berechnung des Analysenergebnisses Standardisierung der Messergebnisse und Qualitätssicherung Beurteilung des Verfahrens Präzision Richtigkeit Nachweisgrenze und Bestimmungsgrenze Störeinflüsse Diskussion der Methode

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Differences in hemoglobin adduct levels of acrylamide in the general population with respect to dietary intake, smoking habits and gender

Cited by 95 publications

References 45 publications

Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmö Diet and Cancer cohort

Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmö Diet and Cancer cohort

Addendum zu Acrylamid [BAT Value Documentation in German language, 2012]

N‐(2‐Carbamoylethyl)valin – Hämoglobin‐Addukt von Acrylamid [Biomonitoring Methods in German language, 2010]

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