Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits

Abstract

Objective. The purpose of the present study is to evaluate the effects of systemically administered zoledronic acid (ZA) on the physiological bone remodeling and the microarchitectural parameters of the condylar part of TMJ in a rabbit model. Study Design. Thirty skeletally mature male New Zealand white rabbits were randomly divided into two groups. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA diluted with 15 mL of saline in a 15-minute perfusion with an infusion pump. The control group was administered only saline infusion for 15 minutes. All rabbits were sacrificed on the 21st postoperative day. Radiodensitometric and histomorphometric examinations were performed on the harvested mandibular condyles. The data were analyzed statistically. Results. Radiodensitometric findings showed that ZA treatment resulted in a significant increase in the mineralization of mandibular condyle. This result was supported by the histomorphometric findings. Conclusion. The present study has revealed that a temporary delay in the physiological bone remodeling using single dose of ZA increases bone mineral content and makes the microarchitecture of the mandibular condyle more compact. These effects may be regarded as base data and considered in numerous clinical situations including TMJ.

Nanohydroxyapatite Based Ceramic Carrier Promotes Bone Formation in a Femoral Neck Canal Defect in Osteoporotic Rats

“…Moreover, there was more compact bone microarchitecture in Group 3, which was not the case in Groups 4 and 5. This overwhelming effect of ZA has been ascribed to the anabolic effect of ZA as shown previously. − Furthermore, another speculation that is possible with local ZA alone in promoting the bone mineralization is that released endogenous cytokines/growth factors might act synergistically to enhance the process of bone healing. The trabecular parameters play a quintessential role in contributing to bone mineral density, architecture, and strength of the femoral neck.…”

The influence of early bisphosphonate treatment on craniofacial radiographic bone density

“…Therefore, in our study, the absence of a difference in bone repair could be due to AL administration prior to surgery rather than after and/or to the possibility that 4 weeks post surgery is an insufficient time for any difference to be visualized in radiographic analysis. Tatli et al [17] demonstrated a temporary delay in physiological bone remodeling using a single dose of ZA. They showed that ZA increased BMC and made the microarchitecture of the mandibular condyle more compact.…”

“…Radiographic analysis is limited in its sensitivity with respect to the detection of changes in bone density that reflect bone resorption or deposition. There are many other methods, such as histology, histomorphometric evaluations, and computed tomography, that are more sensitive in the assessment and quantification of bone repair [7,8,11,17,22]. However, digital and conventional radiography are very common techniques and readily available to most clinicians.…”

The temporomandibular joints disorders in patients with osteoporosis

“…Osteoporosis can occur in the bony components of the joint which are the articular fossa, articular eminence of the temporal bone and the condyle of the mandible that is most commonly affected by bone resorption. [ 18 19 20 ] Moreover, functional harmony of the masticatory system may be disturbed by the impact of general bone loss on the skeleton caused by osteoporosis, which then can result in increase the chance of occurrence of TMJ problems such as Temporomandibular disorders (TMD);[ 3 7 21 ] therefore, patients suffer from pain, tenderness, clicking, weakness, shifting of the jaw to one side, protrusion of the mandible and occasional joint stiffness which can lead to limitation of mouth opening and adversely affects oral health.…”