Effects of zinc deficiency on oral and periodontal diseases in rats

Orbak, Recep; Kara, Cankat; Ozbek, Esma Nida; Tezel, Ayfer; Demir, Turgut

doi:10.1111/j.1600-0765.2006.00939.x

Cited by 43 publications

(32 citation statements)

References 24 publications

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“…Zinc deficiency has also been shown to cause various histologic changes in rat buccal mucosa (18, 19). Rats given a zinc‐deficient diet for 4 weeks showed several minor aphthous ulcers and thickening of the stratum corneum (hyperkeratosis) on the dorsal surface of the tongue (20). In comparison, we alternated a zinc‐deficient and a zinc‐sufficient diet every 4 weeks for 20 weeks to assess the long‐term effects of zinc deficiency on the oral mucosa of rats.…”

Section: Discussionmentioning

confidence: 99%

“…Although serum zinc levels are important, serum level of zinc dose not necessarily correlate with tissue level of that. However, zinc status has been evaluated in many studies by direct analysis of zinc concentrations in serum using atomic absorption spectrophotometry or inductively coupled plasma mass spectrometry (20). We also used this method.…”

Section: Discussionmentioning

confidence: 99%

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Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects

Cho

Han

Lee

et al. 2010

Journal of Oral Pathology &Amp; Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects

Cho

Han

Lee

et al. 2010

Journal of Oral Pathology &Amp; Medicine

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“…In turn, gingival index decrease was occurred in more children in the two groups 78 . In addition to this trial, research in rats also support the dietary zinc beneficial role in certain degree since zinc-deficient diets have been related to lower plaque and gingival indices scores, although probing depth remained unaffected 79 . However, the effect of dietary content of the other two minerals on chronic periodontitis it has just been object of interest as well as the use of nutritional therapy with them.…”

Section: Tocopherols and Tocotrienolsmentioning

confidence: 65%

“…A review on current evidences from animal and human studies tion with other periodontal therapies seems promising but many researches on this topic is needed. 79 . Regarding first, a zinc-supplemented syrup was tested that seemed to exert some beneficial effects in a double-blind randomized study in children.…”

Section: Tocopherols and Tocotrienolsmentioning

confidence: 99%

Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

et al. 2015

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LICENSE 3.0 UNPORTED. RESUMENObjetivos. Dada la relación existente entre periodontitis crónica y altos niveles de estrés oxidativo, esta revisión pretende clarificar qué papel puede desempeñar la ingesta de los diferentes antioxidantes de la dieta en el mantenimiento de un periodonto saludable y en la reducción del riesgo de padecer periodontitis crónica, así como el posible uso de terapias dietéticas basadas en estos para el tratamiento de dicha enfermedad.Métodos. Se utilizó la base de datos de la National Library of Medicine, Washington, DC (MEDLINE: PubMed) y todos los estudios en animales y humanos tratando el tema de interés en escritos Inglés disponibles online desde la creación de la base de datos hasta Mayo de 2015 fueron recopilados.Resultados. Los antioxidantes analizados a este respecto incluyen a la vitamina C, la vitamina A, algunos carotenoides y polifenoles, y el coenzima Q; así como los minerales, hierro, cobre y zinc que forman parte de enzimas antioxidantes. Aun así hay una escasez generalizada de estudios con pocos estudios en humanos, la mayoría de tipo observacional. Entre los diferentes antioxidantes, la vitamina E y los polifenoles parecen ser los que más evidencias a favor de su efecto beneficioso suman, pero en general los estudios son insuficientes para descartar o establecer qué antioxidantes son útiles y cuáles no.Conclusiones. En general, los datos presentados indicarían que los antioxidantes de la dieta resultan beneficiosos para la salud periodontal, al menos bajo ciertas circunstancias. Sin embargo se necesitan más estudios para establecer la relación entre la periodontitis crónica y cada antioxidante concreto así como para diseñar intervenciones dietéticas útiles en la gestión de esta enfermedad. Methods. The database of the National Library of Medicine, Washington, DC (MEDLINE PubMed) was used and all the studies in animals and humans are on the subject of interest in English writing online available from inception of the database until May 2015 were collected.Results. Antioxidants analyzed in this regard include vitamin C, vitamin A, carotenoids and some polyphenols, and coenzyme Q; as well as minerals iron, copper and zinc that are constituents of antioxidant enzymes. Still, there is a paucity of studies with few human studies, mostly observational. Among the various antioxidants, vitamin E and polyphenols seem to have more evidence for its beneficial effect, but Artículo de revisión Review Article Correspondencia CorrespondenceJosé Luis Quiles Morales, Centro de Investigación Biomédica (CIBM), Lab. 250. Universidad de Granada, Avda. del Conocimiento s.n., 18100 Armilla, Granada, España. E-Mail: jlquiles@ugr. es; Tel.: +34958241000 (ext. 20316). Financiación FundingsTrabajo realizado sin financiación. Conflicto de interés Competing interest No hay conflicto de intereses Agradecimientos AcknowledgementsLos autores agradecen a la Junta de Andalucía y a la Universidad de Granada por el continuo soporte al grupo de investigación. Alfonso Varela López es contratado FPU del Ministe...

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“…Thus in cases of zinc deficiency, administration of zinc may have significant therapeutic and prophylactic effects in many diseases such as RAS,[16–23] RHL,[35–9] periodontal diseases as indicated in many studies. [3–923]…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of salivary zinc level in recurrent herpes labialis

Khozeimeh¹,

Jafari²,

Attar³

et al. 2012

Dent Res J

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Background:Recurrent Herpes Labialis (RHL) is one of most common infective vesiculoulcerative lesions. According to some studies administration of topical and/or systemic zinc compositions has been effective in treatment and prevention. This article aims to comparison of zinc level in healthy subjects and RHL patients in acute and convalescent phases.Materials and Methods:This was a retrospective case – control study, carried on 80 individuals (40 normal and 40 RHL patients) mean age=34.5 and 34.4, respectively. Saliva samples were taken in patients in acute phase once and after healing of lesions in convalescent phase (averagely 21 days later) and in normal individuals. Salivary zinc level concentration was measured by flame atomic absorption spectrophotometer by dry digestion method. The results were statistically analyzed with SPSS software by t-test (α=0.05).Results:Results showed that salivary zinc level in case group in acute and convalescent phases were 160.8 ngr/mland 205.7 ngr/ml respectivly and significant differences between them were existed (P <0.05). Also significant differences were existed between zinc concentration in healthy subjects and patient groups (in both phases) (P=.001 and .002 for acute and convalescent phases respectively).Conclusion:According to the results, zinc level is significantly lower in acute phase than in convalescent phase and significantly lower in both phases compared to healthy individuals,so determination of serum zinc level and prescribing zinc complement in low serum status has both treatmental and preventive effects in RHL patients.

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Effects of zinc deficiency on oral and periodontal diseases in rats

Cited by 43 publications

References 24 publications

Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects

Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects

Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

Comparative analysis of salivary zinc level in recurrent herpes labialis

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