Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

Varela‐López, Alfonso; Battino, Maurizio; Bullón, Pedro; Quiles, José L.

doi:10.4321/s2340-98942015000300001

Cited by 13 publications

(16 citation statements)

References 86 publications

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“…There are some reviews which provide information about the association between periodontitis and diet components [ 3 , 24 , 25 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ] although many of them were restricted to certain population groups [ 3 ], study types [ 3 , 24 , 34 ], and/or did not include lipids [ 3 , 24 , 26 , 35 ]. However, few attempts of systematic reviews have been carried out [ 1 , 3 , 24 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans

Varela-López

Giampieri

Bullón

et al. 2016

IJMS

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The risk of different oral problems (root caries, tooth mobility, and tooth loss) can be increased by the presence of periodontal disease, which has also been associated with a growing list of systemic diseases. The presence of some bacteria is the primary etiology of this disease; a susceptible host is also necessary for disease initiation. In this respect, the progression of periodontal disease and healing of the periodontal tissues can be modulated by nutritional status. To clarify the role of lipids in the establishment, progression, and/or treatment of this pathology, a systematic review was conducted of English-written literature in PubMed until May 2016, which included research on the relationship of these dietary components with the onset and progression of periodontal disease. According to publication type, randomized-controlled trials, cohort, case-control and cross-sectional studies were included. Among all the analyzed components, those that have any effect on oxidative stress and/or inflammation seem to be the most interesting according to current evidence. On one hand, there is quite a lot of information in favor of a positive role of n-3 fatty acids, due to their antioxidant and immunomodulatory effects. On the other hand, saturated fat-rich diets increase oxidative stress as well the as intensity and duration of inflammatory processes, so they must be avoided.

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Section: Introductionmentioning

confidence: 99%

Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans

Varela-López

Giampieri

Bullón

et al. 2016

IJMS

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“…These are termed as tocopherols or tocotrienols depending on the phenolic-chromanol ring were saturated or unsaturated, respectively. In addition both can present four forms according to the number and position of methyl groups on the ring: α, β, γ and δ [ 78 ]. As expected, all these forms have been taken into account for this review.…”

Section: Resultsmentioning

confidence: 99%

“…Because of their liposoluble properties, vitamin E is able to incorporate in biological membranes where it inhibits peroxidation of lipids [ 79 , 80 ] due to this well-known antioxidant activity [ 80 ]. As consequence, vitamin E stops the production of ROS formed when fat undergoes oxidation [ 78 ] preventing propagation of damage to cell membranes by peroxyl radicals formed by the oxidation of lipids to stabilize the membrane structure by terminating the free radical chain reaction [ 78 , 79 , 80 ]. Research in animals has allowed to evaluate the use of vitamin E supplements on periodontal diseases and its possible role on ROS and inflammatory processes associated with this conditions [ 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance

et al. 2018

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Periodontal disease, a relevant public health problem worldwide, is generally considered a common pathology of elderly people. In this respect, there is agreement about that nutritional status may be a modifying factor in the progression and healing of the periodontal tissues. Vitamins have been recommended as nutraceuticals for prevention and treatment of some pathological conditions, such as cardiovascular diseases, obesity or cancer. Thus, a systematic approach to determining how the different vitamin type could ameliorate periodontal risks or improve periodontal health is necessary to further the understanding of the potential benefits and risks of vitamins supplementation use. For this, a systematic review of English-written literature in PubMed until February 2018, which included both human and animal research on the relationship of each vitamin with periodontal disease, was conducted. Among all the analyzed vitamins those with antioxidant capacity and effects on immune system seem to be useful for prevention or improvement of periodontal disease, as well as those implicated in bone metabolism. In the first case, there are quite information in favor of various vitamins, mainly vitamin C, that is the most studied. In the second case, vitamin D seems to have the most relevant role.

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“…which is a critical in ammatory mediator and unexpectedly elevated in chronic periodontitis [15]. In order to extend the existing investigation on the role of LOXL1-AS and link the in ammation with periodontitis, this study was then carried out to investigate the potential effects of LOXL1-AS and IL-1β on periodontitis.…”

Section: Discussionmentioning

confidence: 99%

LncRNA LOXL1-AS inhibits proliferation of PDLSCs and downregulates IL-1β in periodontitis patients

Ruan¹,

Wu²

2021

Preprint

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Background: Oncogenic role of lncRNA LOXL1-AS has been characterized in several types of cancer. Our preliminary deep sequencing data revealed the downregulation of LOXL1-AS in periodontitis and its inverse correlation with IL-1β, a critical inflammatory mediator in periodontitis. This study was therefore performed to investigate the potential interaction between LOXL1-AS and IL-1β in periodontitis.Methods: Research subjects of this study included 30 periodontitis patients and 30 healthy controls. Cell transfection, RT-qPCR, luciferase activity assay and western blots were performed in this study.Results: LOXL1-AS was downregulated in periodontitis-affected periodontal ligament stem cells (PDLSCs) than that in healthy PDLSCs. While IL-1β was upregulated in periodontitis-affected PDLSCs and was inversely correlated with LOXL1-AS. Overexpression of LOXL1-AS mediated the downregulation of IL-1β in PDLSCs. IL-1β treatment did not affect the expression of LOXL1-AS. Moreover, overexpression of LOXL1-AS led to inhibited proliferation of periodontitis-affected PDLSCs. Conclusion: This study is the first to report the downregulation of LOXL1-AS in periodontitis. Moreover, we also propose that LOXL1-AS may inhibit the proliferation of periodontitis-affected PDLSCs and downregulate IL-1β to improve periodontitis.

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Dietary antioxidants for chronic periodontitis prevention and its treatment: a review on current evidences from animal and human studies

Cited by 13 publications

References 86 publications

Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans

Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans

Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance

LncRNA LOXL1-AS inhibits proliferation of PDLSCs and downregulates IL-1β in periodontitis patients

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