Effects of Wuweizi syrup on brain aging mice model induced by d-galactose

Peng, Mengfan; Fang, Xiaoyan; Miao, Mingsan; Wang, Tan

doi:10.1016/j.jksus.2020.03.032

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…Aging is one of the most important factors involved in the gradual functional decline and structural degeneration of the brain and has been implicated in memory impairment, which is a major symptom of Alzheimer's disease (AD) [1][2][3]. Due to the rapid aging of the population, memory impairment seriously affects the quality of life of a large number of elderly individuals [4,5]. Recent studies of cerebral energy metabolism have shown that mitochondrial dysfunction, oxidative stress, excessive levels of advanced glycation end products, and neurotoxicity are involved in the pathogenesis of memory impairment [6,7].…”

Section: Introductionmentioning

confidence: 99%

Microbiome-Metabolomics Reveals Endogenous Alterations of Energy Metabolism by the Dushen Tang to Attenuate D-Galactose-Induced Memory Impairment in Rats

Wang

Guo

et al. 2021

BioMed Research International

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Aging affects the brain function in elderly individuals, and Dushen Tang (DST) is widely used for the treatment of senile diseases. In this study, the protective effect of DST against memory impairment was evaluated through the Morris water maze (MWM) test and transmission electron microscopy (TEM). A joint analysis was also performed using LC-MS metabolomics and the microbiome. The MWM test showed that DST could significantly improve the spatial memory and learning abilities of rats with memory impairment, and the TEM analysis showed that DST could reduce neuronal damage in the hippocampus of rats with memory impairment. Ten potential biomarkers involving pyruvate metabolism, the synthesis and degradation of ketone bodies, and other metabolic pathways were identified by the metabolomic analysis, and it was found that 3-hydroxybutyric acid and lactic acid were involved in the activation of cAMP signaling pathways. The 16S rDNA sequencing results showed that DST could regulate the structure of the gut microbiota in rats with memory impairment, and these effects were manifested as changes in energy metabolism. These findings suggest that DST exerts a good therapeutic effect on rats with memory impairment and that this effect might be mainly achieved by improving energy metabolism. These findings might lead to the potential development of DST as a drug for the treatment of rats with memory impairment.

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Section: Introductionmentioning

confidence: 99%

Microbiome-Metabolomics Reveals Endogenous Alterations of Energy Metabolism by the Dushen Tang to Attenuate D-Galactose-Induced Memory Impairment in Rats

Wang

Guo

et al. 2021

BioMed Research International

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“…In line with this finding, a previous study [ 36 ] reported reduced cell number and disordered arrangement of hippocampal neurons in the D-galactose model group. The finding of fewer cerebral cortical nerve cells, decreased number of pyramidal cells, sparse and irregular arrangement, and decreased cell volume and nuclear pyknosis was also reported in the D-galactose model group [ 37 ].…”

Section: Resultsmentioning

confidence: 62%

Lacticaseibacillus rhamnosus-Derived Exopolysaccharide Attenuates D-Galactose-Induced Oxidative Stress and Inflammatory Brain Injury and Modulates Gut Microbiota in a Mouse Model

et al. 2022

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This study aimed to investigate the protective effect of a novel exopolysaccharide EPSRam12, produced by Lacticaseibacillus rhamnosus Ram12, against D-galactose-induced brain injury and gut microbiota dysbiosis in mice. The findings demonstrate that EPSRam12 increases the level of antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, total antioxidant capacity, and the level of anti-inflammatory cytokine IL-10, while decreasing malonaldehyde, nitric oxide, pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, MCP-1, and the mRNA expression of cyclooxygenase-2, inducible nitric oxide synthase, and the activation of nuclear factor-kappa-B in the brain tissues of D-galactose-treated mice. Further analyses reveal that EPSRam12 improves gut mucosal barrier function and increases the levels of short-chain fatty acids (SCFAs) in the intestine while restoring gut microbial diversity by enriching the abundance of SCFA-producing microbial genera Prevotella, Clostridium, Intestinimonas, and Acetatifactor while decreasing potential pathobionts including Helicobacter. These findings of antioxidative and anti-inflammatory effects in the brain and ameliorative effects on epithelial integrity, SCFAs and microbiota in the gut, provide novel insights into the effect of EPSRam12 intervention on the gut–microbiome–brain axis and should facilitate prospective understanding of microbial exopolysaccharide for improved host health.

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“…Furthermore, in the D‐galactose and rapid aging model, increased MDA caused cellular and tissue organ damage (Wang et al, 2020). Wuweizi syrup was found to improve free radical metabolism disorder and reduce lipid peroxidation damage, resulting in an anti‐aging effect by increasing the levels of CAT, GSH‐Px, and SOD (Peng et al, 2020). Yuan et al demonstrated that subcutaneous D‐galactose injection decreased the levels of CAT, GSH‐Px, and SOD while increasing MDA content in aging rats, which was significantly reversed by the intervention of Ganoderma lucidum Rhodiola compound preparation (GRCP) (Yuan et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Effects of Rosa roxburghii Tratt glycosides and quercetin on D‐galactose‐induced aging mice model

Chen

Zhu

et al. 2022

Journal of Food Biochemistry

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To investigate the effects of RRT (Rosa roxburghii Tratt) glucosides and quercetin on oxidative stress and chronic inflammation in D‐galactose‐induced aging mice, 90 mice (8 weeks old) were randomly divided into the normal group (NC), aging model group (D‐gal), isoquercitrin group (D‐gal+isoquercitrin), quercitrin group (D‐gal+quercitrin), quercetin group (D‐gal+quercetin) and positive control group (D‐gal+Metformin). The aging model was established by subcutaneous injection of D‐galactose (100 mg/kg). After 42 days of the administration, antioxidant and inflammatory indexes were measured, HE staining was used to investigate pathological changes in liver and brain tissue, and Western blot was used to determine the protein abundance of nuclear factor E2‐related factor (Nrf2) and heme oxygenase (HO‐1) in the brain. The results showed that, when compared to the NC group, the D‐gal group had a significantly lower brain, liver, kidney, and spleen indexes; the contents of MDA, L‐1β, IL‐6, and TNF‐α in serum, liver, and brain were significantly higher, but the levels of CAT, SOD, and GSH‐Px were significantly lower. Isoquercitrin, quercitrin, and quercetin significantly increased organ indexes and activities of CAT, SOD, and GSH‐Px while decreasing MDA, IL‐1β, IL‐6, and TNF‐α levels in serum, liver, and brain tissues compared to the D‐gal group. The morphological changes in the brain and liver tissue were significantly restored by glycosides and quercetin, as observed in HE staining. Furthermore, Western blot results revealed that glycosides and quercetin increased the protein levels of Nrf2, HO‐1, and NQO1. Finally, the antioxidant and anti‐inflammatory effects of RRT glycoside and quercetin in aging may be attributed to an activated Nrf2/HO‐1 signaling pathway. Practical applications Aging is characterized by physical changes and dysfunction of numerous biological systems caused by a variety of factors. The oxidative stress and inflammatory effects of RRT glycosides and quercetin on D‐galactose‐induced aging mice were investigated in this study. RRT glycosides and quercetin were found to protect organ atrophy, liver, and brain tissue in aging mice by regulating oxidative stress and chronic inflammation. It served as the theoretical foundation for the investigation of Rosa roxburghii Tratt as a health product and pharmaceutical raw material.

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Effects of Wuweizi syrup on brain aging mice model induced by d-galactose

Cited by 5 publications

References 4 publications

Microbiome-Metabolomics Reveals Endogenous Alterations of Energy Metabolism by the Dushen Tang to Attenuate D-Galactose-Induced Memory Impairment in Rats

Microbiome-Metabolomics Reveals Endogenous Alterations of Energy Metabolism by the Dushen Tang to Attenuate D-Galactose-Induced Memory Impairment in Rats

Lacticaseibacillus rhamnosus-Derived Exopolysaccharide Attenuates D-Galactose-Induced Oxidative Stress and Inflammatory Brain Injury and Modulates Gut Microbiota in a Mouse Model

Effects of Rosa roxburghii Tratt glycosides and quercetin on D‐galactose‐induced aging mice model

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