Effects of wild ginseng (Panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats

Jung, Chang-Hwa; Seog, Ho-Moon; Choi, In-Wook; Choi, Hee‐Don; Cho, Hong-Yon

doi:10.1016/j.jep.2004.12.030

Cited by 113 publications

(71 citation statements)

References 28 publications

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“…Accordingly, numerous bioactive plant materials have been investigated for their antioxidant potential (4,(6)(7)(8). In the present study, to the best of our knowledge, we demonstrate for the first time that FBG protects HepG2 cells against H 2 O 2 -induced oxidative stress through the regulation of ROS production and antioxidant enzymes, and signaling pathways including MAPKs.…”

Section: Discussionsupporting

confidence: 51%

“…Our results are in accordance with those of these studies, suggesting that FBG may prove useful against oxidate stress by reducing ROS levels and increasing antioxidant enzymes activity and expression. According to previous studies, a variety of ginsengs has shown antioxidant properties in maintaining cellular function against free radicals in vivo, as well as in vitro (4,7,37). In addition, the activity of intracellular antioxidant enzymes, such as SOD, CAT and GPx plays an important role in protecting cells against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Phytochemicals provide further protection against oxidative damage from free radicals. A large number of studies have indicated that phytochemicals present in fruits, vegetables and herbs, exert their antioxidant effects against oxidative stress through the induction or activation of these endogenous antioxidant enzymes (6)(7)(8)(9). In addition, increased ROS production not only directly damages cells by oxidizing macromolecules, such as DNA and lipids, but also indirectly by triggering mitogen-activated protein kinase (MAPK) signaling pathways (10).…”

Section: Introductionmentioning

confidence: 99%

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Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells

Bak

Jeong

Kim

2014

International Journal of Molecular Medicine

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Abstract. Fermented black ginseng (FBG) is prepared by repeated steaming and drying processes with fresh ginseng followed by fermentation with Saccharomyces cerevisiae. It has recently been shown to have several bioactivities. FBG contains crude saponin (1,440 µg/ml), ginsenoside Rg2 (2.86 µg/ml), ginsenoside Rg3 (24.52 µg/ml), ginsenoside Rh1 (12.64 µg/ml), ginsenoside Rh2 (0.63 µg/ml) and ginsenoside Rf (1.32 µg/ml). The present study investigated the antioxidant defense properties of FBG against hydrogen peroxide (H 2 O 2 )-mediated oxidative stress in HepG2 human hepatocellular carcinoma cells. The increased production of reactive oxygen species (ROS) induced by H 2 O 2 was attenuated in a dose-dependent manner when the cells were pre-treated with FBG (10-50 µg/ml). FBG induced both the expression and activity of antioxidant enzymes, such as superoxide dismutase, catalase and glutathione peroxidase in the H 2 O 2 -treated HepG2 cells. The inhibitory effects of FBG on the phosphorylation of upstream mitogen-activated protein kinases (MAPKs), such as c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38 were also observed. Overall, our results demonstrate that FBG protects HepG2 cells from oxidative stress through the induction of antioxidant enzyme activity and the inhibition of MAPK pathways.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells

Bak

Jeong

Kim

2014

International Journal of Molecular Medicine

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“…P. ginseng is a well-known medicinal herb containing multiple bioactive constituents that is extensively used in China and Korea. The plant has a variety of beneficial activities including antitumor, antioxidant, anti-aging, antifungal, anti-inflammatory and neuroprotective properties (85)(86)(87)(88)(89)(90). Ginseng contains various types of ginsenosides (major active components), kaempferol, caffeic acids, acidic polysaccharides and palmitic acids in its stem, leaves and roots.…”

Section: Zingiber Officinalementioning

confidence: 99%

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

et al. 2017

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Abstract. The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation-induced damage. The potential for antioxidants to decrease normal tissue damage induced by radiation has been investigated in animal models for a number of decades. In attempts for radioprotection, certain synthetic chemicals are suggested as antioxidants and normal tissue protectors against radiation-induced damage, but they have exhibited limitations in pharmacological application due to undesirable effects and high toxicities at clinical doses. The present review focuses on the radioprotective efficacy of traditional oriental medicines with the advantage of low toxicity at pharmacological doses and how such treatments may influence various harmful effects induced by radiation in vitro and in vivo. In addition, medicinal plants and their active constituents with biological activities that may be associated with alleviation of radiation-induced damage through antioxidant, anti-inflammatory, wound healing and immunostimulatory properties are discussed.

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“…Panax ginseng C.A. Meyer (Araliaceae), grows in China and Korea and more than 30 ginseng saponins (ginsenosides) have been isolated as the main biologically active constituents that include anti-carcinogenic, anti-diabetic and anti-inflammatory effects, as well as cardiovascular protection and neuroprotection (Zhang et al, 1996;Yun et al, 2001;Joo et al, 2005;Jung et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Stability of Korean Ginseng in Herbal Drug Product

Babiker¹

2014

American Journal of Applied Sciences

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This study was designed to investigate long term stability of K-Gin capsules, a herbal medication that contains korean ginseng. Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. Conducting long term stability studies following the guidelines issued by ICH, WHO and USP. The drug was stored under different climatic conditions: (25±1°C, humidity: 75%) Chamber 1(CH1); (30±1°C, humidity: 75%) Chamber 2(CH2) and (40±1°C, humidity 75%) Chamber 3(CH3) for 24 months,evaluation of capsulestchemicaly (ginsenosides Rg1 and Rb1), physicaly and microbiologicaly, besides determination of certain elements including heavy metals, detection of pesticides residues and mycotoxins. The activation energies were found to be 10.99 and 10.2 (k.cal.mol −1 ) for Rg1 and Rb1 respectively. The calculated t 1/2 values for Rg1 were found to be 94 months in (CH1), 68.4 months in (CH2) and 51 months in (CH3). For Rb1 were found to be 100.3 months in (CH1), 73.39 months in (CH2) and 56.7 months in (CH3). Capsules assay results for Rg1 after 24 months period of study were found to be 98.93% in (CH1), 97.13% in (CH2) and 96.43% in (CH3). For Rb1 96.93% in (CH1), 96.83% in (CH2) and 96.13% in (CH3). Studies on the elemental composition confirmed absence of toxic heavy metals. Microbiological studies revealed no significant changes in total viable aerobic count of bacteria and fungi. The capsules were found to be free from any pesticides residues and the mycotoxins content was 723 ng kg −1 . The methods involved in this study covered, High Performance Liquid Chromatography (HPLC), Atomic Absorption Spectroscopy (AAS), Gas Chromatography-Mass Spectrometry (GC-MS) and ELISA. The results were found to be within the allowable limits stated in the guidelines. From this study K-Gin capsules were proved to be stable chemicaly and physicaly under studied storage conditions for 24 months.

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Effects of wild ginseng (Panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats

Cited by 113 publications

References 28 publications

Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells

Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

Investigation of Stability of Korean Ginseng in Herbal Drug Product

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