Effects of vitamin D on neonatal sepsis: A systematic review and meta‐analysis

Bitew, Zebenay Workneh; Worku, Teshager; Alemu, Ayinalem

doi:10.1002/fsn3.2003

Cited by 15 publications

(6 citation statements)

References 81 publications

(238 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data are presented as mean ± SD 1 or as n (% of the group) for the remaining variables. Groups were compared using t-test 1 , chi-square test 2 , or the Fisher exact test (remaining variables). 3 Vitamin D level between groups compared without any covariates (t-test) and with adjustment to: GA age, birth weight, vit.…”

Section: Resultsmentioning

confidence: 99%

“…Data are presented as mean ± SD for bone mass and as n (%) for the remaining variables. Groups are compared using t-test 1 , chi-square test 2 , or the Fisher exact test (remaining variables). MD 1 : mean difference between groups calculated as monitored group minus control group with 95% confidence interval (CI).…”

Section: Resultsmentioning

confidence: 99%

“…Vitamin D plays an important role in skeletal health [1], and its receptors are in most tissues. Therefore, an appropriate supplementation in perinatal and neonatal periods affects respiratory infections, sepsis, allergy, and mental and behavioral development [2][3][4][5][6]. Neonatal vitamin D storage depends on 50-70% of the maternal 25-hydroxyvitamin D [25(OH)D] levels received by newborns [7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Kołodziejczyk-Nowotarska,

Bokiniec,

Seliga-Siwecka

2021

Nutrients

View full text Add to dashboard Cite

Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy (n = 55; approximately 800–1000 IU from combined sources) or monitored therapy (n = 54; with an option of dose modification). 25-hydroxyvitamin D [25(OH)D] concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52 ± 2 weeks of post-conceptional age (PCA). Vitamin D supplementation was discontinued in 23% of infants subjected to standard treatment due to increased potentially toxic 25(OH)D concentrations (>90 ng/mL) at 40 weeks of PCA. A significantly higher infants’ percentage in the monitored group had safe vitamin D levels (20−80 ng/mL) at 52 weeks of PCA (p = 0.017). We observed increased vitamin D levels and abnormal ultrasound findings in five infants. Biochemical markers of vitamin D toxicity were observed in two patients at 52 weeks of PCA in the control group. Inadequate and excessive amounts of vitamin D can lead to serious health problems. Supplementation with 800–1000 IU of vitamin D prevents deficiency and should be monitored to avoid overdose.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Kołodziejczyk-Nowotarska,

Bokiniec,

Seliga-Siwecka

2021

Nutrients

View full text Add to dashboard Cite

show abstract

“…The associations between neonatal sepsis and cord blood vitamin D levels have been well reported. A meta-analysis of 18 studies revealed that low maternal and cord blood vitamin D levels were significantly associated with the incidence of neonatal sepsis 84 . Additionally, a study on 4,340 neonates appropriate for gestational age found a negative correlation between cord blood NLR and fetal malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Prenatal vitamin D deficiency alters immune cell proportions of young adult offspring through alteration of long-term stem cell fates

Ueda,

Chin,

Sato

et al. 2023

Preprint

View full text Add to dashboard Cite

Vitamin D deficiency is a common deficiency worldwide, particularly among women of reproductive age. During pregnancy, it increases the risk of immune-related diseases in offspring later in life. However, exactly how the body remembers exposure to an adverse environment during development is poorly understood. Herein, we explore the effects of prenatal vitamin D deficiency on immune cell proportions in offspring using vitamin D deficient mice established by dietary manipulation. We show that prenatal vitamin D deficiency alters immune cell proportions in offspring by changing the transcriptional properties of genes downstream of vitamin D receptor signaling in hematopoietic stem and progenitor cells of both the fetus and adults. Further investigations of the associations between maternal vitamin D levels and cord blood immune cell profiles from 75 healthy pregnant women and their term babies also confirm that maternal vitamin D levels significantly affect immune cell proportions in the babies. Thus, lack of prenatal vitamin D, particularly at the time of hematopoietic stem cell migration from the liver to the bone marrow, has long-lasting effects on immune cell proportions. This highlights the importance of providing vitamin D supplementation at specific stages of pregnancy.

show abstract

“…The risks for developing EOS include prematurity, low birth weight, prolonged labor, prenatal asphyxia, pre-mature rupture of amniotic membrane, foul smelling amniotic fluid, or the presence of meconium (11). Another study showed neonates born to mothers with low vitamin D levels and neonates with low cord vitamin D levels were at risk for neonatal sepsis (15).…”

Section: Introductionmentioning

confidence: 99%

Association Between Maternal and Neonatal Serum Vitamin D Levels and the Incidence of Early-Onset Sepsis

2021

View full text Add to dashboard Cite

Background: Early-onset neonatal sepsis (EOS) is a systemic infection that occurs within the first week of life. Objectives: This study investigated the association of serum vitamin D levels in pregnant women and their neonates with the prevalence of EOS. Methods: This case-control study was performed among 50 term/late pre-term neonates admitted to our NICU due to EOS, alongside 50 healthy neonates matched for gestational age range and sex. Maternal and neonatal serum vitamin D levels were measured. The criteria for diagnosing EOS included any/combination of: respiratory, cardiovascular, hemodynamic, neurological, gastrointestinal, body temperature, or metabolic signs. For sepsis cases, CBC, CRP, blood type, blood culture, chest X ray, and in some cases, and CSF analysis and culture were tested. Mothers’ clinical history was collected. Results: Each group included 30 (60%) male and 20 (40%) female neonates. Birth weight averages were 2772 ± 667 and 3215 ± 349 grams in the case and control groups, respectively (P < 0.001). The mean serum vitamin D levels were 49.75 ± 25.53 and 56.41 ± 18.17 nmol/L in the case and control groups, respectively. The control group mothers had a significantly higher vitamin D level (68.24 nmol/L versus 55.01 in mothers of sepsis cases, p=0.005) and showed a correlation with the vitamin D levels of their neonates (R = 0.731, P < 0.001), while the data failed to show a correlation between vitamin D level in mothers and their neonates in the sepsis group (R = 0.241, P = 0.115). C-section delivery was more prevalent among the sepsis cases (P < 0.001). Conclusions: Early-onset neonatal sepsis is associated with vitamin D deficiency in neonates and their mothers, low birth weight, and being delivered by C-section.

show abstract

Effects of vitamin D on neonatal sepsis: A systematic review and meta‐analysis

Cited by 15 publications

References 81 publications

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Prenatal vitamin D deficiency alters immune cell proportions of young adult offspring through alteration of long-term stem cell fates

Association Between Maternal and Neonatal Serum Vitamin D Levels and the Incidence of Early-Onset Sepsis

Contact Info

Product

Resources

About