Prenatal vitamin D deficiency alters immune cell proportions of young adult offspring through alteration of long-term stem cell fates
Koki Ueda,
Shu Shien Chin,
Noriko Sato
et al.
Abstract:Vitamin D deficiency is a common deficiency worldwide, particularly among women of reproductive age. During pregnancy, it increases the risk of immune-related diseases in offspring later in life. However, exactly how the body remembers exposure to an adverse environment during development is poorly understood. Herein, we explore the effects of prenatal vitamin D deficiency on immune cell proportions in offspring using vitamin D deficient mice established by dietary manipulation. We show that prenatal vitamin D… Show more
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