Effects of vitamin D and parathyroid hormone on muscle: potential role in uremic myopathy

Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.

“…Vitamin D deficiency is associated with both hyperparathyroidism and metabolic acidosis (1,39,40 (45) had previously reported that specific receptors exist in the pancreas for 1,25(OH)2D3 and proposed that this metabolite acts directly on pancreatic a-cells to increase calcium uptake, thus stimulating insulin release in vivo. Our data also support a role for vitamin D exclusive of extracellular calcium in the control of plasma insulin levels.…”

“…The association between vitamin D deficiency states and muscle abnormalities has been noted frequently (1)(2)(3)(4). Vitamin D deficiency is associated with a proximal myopathy and histologic evidence of muscle fiber atrophy, which rapidly improve after the administration of vitamin D3 or its metabolites (5)(6)(7)(8).…”

Estado nutricional e ingestão alimentar de pacientes em diálise peritoneal contínua com e sem hiperparatireoidismo secundário

“…Elevados níveis de interleucina-6 em indivíduos idosos têm sido recentemente associados com menor massa muscular e reduzida força muscular. 34 Os estudos de Ritz et al, 35 Visser et al 34 e Rezende et al 36 demonstraram que altos níveis de PTH podem, direta ou indiretamente, exercer uma ação tóxica no metabolismo energético e proteico, induzindo o catabolismo e o balanço nitrogenado negativo, bem como alterações na composição corporal, aumentando, por conseguinte, as limitações funcionais e a mortalidade.…”

The Importance of Exercise Programs in Haemodialysis Patients

“…Muscle atrophy, a neuropathic process and myopathy are potential causes of the muscular weakness. It is suggested that myopathy is due to abnormal energy metabolism (Thompson et al 1993), secondary hyperparathyreoidism (Ritz et al 1980), malnutrition (Guarnieri et al 1983), prolonged physical inactivity (Jones et al 1990) and to uraemia itself . It is important that the consultant renal physiotherapist, renal nurse, renal dietician and renal physician have an understanding of limitations in physical fitness and physical functioning that adults with CKD are expected to face and how various unique issues may alter the treatment approach.…”