A B S T R A C T The myopathy associated with vitamin D deficiency was examined in vitamin D-deficient and vitamin D-supplemented rats. When compared with either vitamin D-supplemented ad lib. or pair-fed rats, weight gain and muscle mass were decreased in vitamin D-deficient hypocalcemic animals. With the exception of a modest decrease in muscle creatine phosphate levels, muscle composition was unchanged by vitamin D deficiency. Muscle protein turnover rates were determined in both in vivo and in vitro studies and demonstrated that myofibrillar protein degradation was increased in vitamin D deficiency. Normal growth rates could be maintained be feeding the rats vitamin D-deficient diets containing 1.6% calcium, which maintained plasma calcium within the normal range. In addition to its role in maintaining plasma calcium, vitamin D-supplemented rats had significantly higher levels of the anabolic hormone insulin. Vitamin D supplementation may affect muscle protein turnover by preventing hypocalcemia, as well as directly stimulating insulin secretion, rather than by a direct effect within skeletal muscle.
Excitation functions of the reaction 12 C( 12 C,/>) 23 Na reveal a distinct set of resonances in the # + , f + , (f + ), and (# + ) members of the 23 Na Jfi C l r = -| + ground-state band near E x ( u Ug) = 25.2, 28.2, and 33.3 MeV. These plus earlier data suggest the possible existence of an excited collective band in 24 Mg with very high deformation and large 12 C + 12 C width.
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