Effects of verapamil on reoxygenation and programmed electrical stimulation-induced ventricular arrhythmias in the isolated heart

Pahor, Marco; Bernabei, Roberto; Gambassi, Giovanni; Carbonin, P. U.

doi:10.1016/0167-5273(89)90096-x

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…The study by Pahor et al (1989) demostrated the antiarrhythmic effect of verapamil on spontaneous ventricular arrhythmias during reoxygenation after 15 min of glucose-free hypoxia and on programmed electrical stimulation-induced ventricular fibrillation in isolated Langendorff-perfused guinea pig hearts. Verapamil added during reoxygenation reduced the incidence of reoxygenation arrhythmias and ventricular fibrillation, but it had no effect on programmed stimulation-induced ventricular fibrillation.…”

Section: The Electrical Stability Of the Heart In A Hypoventilation/reoxygenation Modelmentioning

confidence: 99%

Cardiac Arrhythmias - New Considerations

Breijo-Marquez¹

2012

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Section: The Electrical Stability Of the Heart In A Hypoventilation/reoxygenation Modelmentioning

confidence: 99%

Cardiac Arrhythmias - New Considerations

Breijo-Marquez¹

2012

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“…Myocardial hypoxia reduces left ventricular contractile performance ( Tanonaka et al, 1989;Draper & Shah, 1997;Jeroudi et al, 1994;Kang et al, 2000); however, recovery of the contractile force was less than 10% and recovery of the myocardial high-energy phosphates during reoxygenation was approximately 40% (Tanonaka et al, 1989). The study by Pahor et al (1989) demostrated the antiarrhythmic effect of verapamil on spontaneous ventricular arrhythmias during reoxygenation after 15 min of glucose-free hypoxia and on programmed electrical stimulation-induced ventricular fibrillation in isolated Langendorff-perfused guinea pig hearts. Verapamil added during reoxygenation reduced the incidence of reoxygenation arrhythmias and ventricular fibrillation, but it had no effect on programmed stimulation-induced ventricular fibrillation.…”

Section: The Electrical Stability Of the Heart In A Hypoventilation/rmentioning

confidence: 99%