Effects of various histamine H2-receptor antagonists on gastrointestinal motility and gastric emptying.

Ohira, Youichi; Hanyu, Nobuyoshi; Aoki, Teruaki; Hashimoto, Yoshihiro; Iikura, M; Fukuda, Shinichiro

doi:10.1540/jsmr.29.131

Cited by 13 publications

(8 citation statements)

References 7 publications

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“…Profiles of gastric emptying of liquid meals obtained using APT have been shown to be reproducible and similar to those obtained using scintigraphy, provided that acid secretion is inhibited by cimetidine [18]. Cimetidine has been shown to have no effect on gastric emptying [19,20]. The components of the test meal used were: 300 cc tomato juice, 40·5 g Fantomalt TM (Nutricia Nederland B.V.), 13·5 g Protifar TM (Nutricia Nederland B.V.), 4·5 g bouillon powder, and 18 cc corn oil.…”

Section: Methodsmentioning

confidence: 95%

The effect of coffee on gastric emptying and oro‐caecal transit time

Boekema

Samsom

et al. 2000

Eur J Clin Investigation

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Section: Methodsmentioning

confidence: 95%

The effect of coffee on gastric emptying and oro‐caecal transit time

Boekema

Samsom

et al. 2000

Eur J Clin Investigation

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“…224 In terms of effects on cytochrome P-450, ranitidine is reported to be much less active than cimetidine, 237,238 although famotidine does not appear to have any effect at therapeutic doses. 239,240 However, ranitidine has been reported to either accelerate, [241][242][243] have no effect, 244,245 or delay gastric emptying in humans. 246,247 Cimetidine 241,246,247 and famotidine 243,248 have no effect on the rate of gastric emptying in humans.…”

Section: Predictive Approaches To Assessing Ph-dependent Bioavailabilitymentioning

confidence: 99%

“…239,240 However, ranitidine has been reported to either accelerate, [241][242][243] have no effect, 244,245 or delay gastric emptying in humans. 246,247 Cimetidine 241,246,247 and famotidine 243,248 have no effect on the rate of gastric emptying in humans. Proton pump inhibitors, such as omeprazole and lansoprazole, can effectively elevate gastric pH above 4.0 on a round-the-clock basis.…”

Section: Predictive Approaches To Assessing Ph-dependent Bioavailabilitymentioning

confidence: 99%

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Charman

Porter

Mithani

et al. 1997

Journal of Pharmaceutical Sciences

543

343

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Drugs are absorbed after oral administration as a consequence of a complex array of interactions between the drug, its formulation, and the gastrointestinal (GI) tract. The presence of food within the GI tract impacts significantly on transit profiles, pH, and its solubilization capacity. Consequently, food would be expected to affect the absorption of co-administered drugs when their physicochemical properties are sensitive to these changes. The physicochemical basis by which ingested food/lipids induce changes in the GI tract and influence drug absorption are reviewed. The process of lipid digestion is briefly reviewed and considered in the context of the absorption of poorly water-soluble drugs. The effect of food on GI pH is reviewed in terms of location (stomach, upper and lower small intestine) and the temporal relationship between pH and drug absorption. Case studies are presented in which postprandial changes in bioavailability are rationalized in terms of the sensitivity of the physicochemical properties of the administered drug to the altered GI environment.

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“…Previous investigations on the effect of oral H 2 ‐receptor antagonists on gastric emptying have yielded equivocal results, as H 2 ‐receptor blockade has been found to facilitate (Ohira et al. ) and delay (Forrest et al. ) gastric emptying in humans.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, an impact of H 1 -and H 2 -receptor blockade on gastric emptying could help explain the results of this study. Previous investigations on the effect of oral H 2 -receptor antagonists on gastric emptying have yielded equivocal results, as H 2 -receptor blockade has been found to facilitate (Ohira et al 1993) and delay (Forrest et al 1976) gastric emptying in humans. However, in the current investigation, the nonexercise sham protocol was undertaken to examine the effect of H 1 -and H 2 -receptor blockade on insulin sensitivity in the absence of prior exercise.…”

Section: Determinants Of Insulin Sensitivity Following Exercisementioning

confidence: 97%

Effect of H₁- and H₂-histamine receptor blockade on postexercise insulin sensitivity

2013

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Following a bout of dynamic exercise, humans experience sustained postexercise vasodilatation in the previously exercised skeletal muscle which is mediated by activation of histamine (H1 and H2) receptors. Skeletal muscle glucose uptake is also enhanced following dynamic exercise. Our aim was to determine if blunting the vasodilatation during recovery from exercise would have an adverse effect on blood glucose regulation. Thus, we tested the hypothesis that insulin sensitivity following exercise would be reduced with H1- and H2-receptor blockade versus control (no blockade). We studied 20 healthy young subjects (12 exercise; eight nonexercise sham) on randomized control and H1- and H2-receptor blockade (fexofenadine and ranitidine) days. Following 60 min of upright cycling at 60% VO2 peak or nonexercise sham, subjects consumed an oral glucose tolerance beverage (1.0 g/kg). Blood glucose was determined from “arterialized” blood samples (heated hand vein). Postexercise whole-body insulin sensitivity (Matsuda insulin sensitivity index) was reduced 25% with H1- and H2-receptor blockade (P < 0.05), whereas insulin sensitivity was not affected by histamine receptor blockade in the sham trials. These results indicate that insulin sensitivity following exercise is blunted by H1- and H2-receptor blockade and suggest that postexercise H1- and H2-receptor–mediated skeletal muscle vasodilatation benefits glucose regulation in healthy humans.

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Effects of various histamine H2-receptor antagonists on gastrointestinal motility and gastric emptying.

Cited by 13 publications

References 7 publications

The effect of coffee on gastric emptying and oro‐caecal transit time

The effect of coffee on gastric emptying and oro‐caecal transit time

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Effect of H₁- and H₂-histamine receptor blockade on postexercise insulin sensitivity

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Effects of various histamine H2-receptor antagonists on gastrointestinal motility and gastric emptying.

Cited by 13 publications

References 7 publications

The effect of coffee on gastric emptying and oro‐caecal transit time

The effect of coffee on gastric emptying and oro‐caecal transit time

Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH

Effect of H1- and H2-histamine receptor blockade on postexercise insulin sensitivity

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Product

Resources

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Effect of H₁- and H₂-histamine receptor blockade on postexercise insulin sensitivity