Effects of Ureteral Pressure Increase on Renal Hemodynamics and the Handling of Electrolytes and Water

Selkurt, Ewald E.; Brandfonbrener, Martin; Geller, Herman M.

doi:10.1152/ajplegacy.1952.170.1.61

Cited by 50 publications

(13 citation statements)

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“…With increases of pressure larger than those used here GFR usually decreased, and so it was inferred that the GFR decrease somehow caused the decreased UNaV that followed ureteral pressure elevation (2). The possibility that this might not be the entire explanation arose during experiments on the effect of increased ureteral back pressure on the excretion of urea (3).…”

Section: Methodsmentioning

confidence: 88%

“…Effective renal plasma flow was not measured in these experiments but very likely did not decrease much. Share (1) and Selkurt, Brandfonbrener, and Geller (2) found that the clearance of para-aminohippurate (CPAH) usually decreased less than did Ccr, and sometimes it in- creased even though Ccr decreased modestly during increased ureteral back pressure. Of course, obstruction may cause changes of medullary blood flow that might not be reflected by changes of CPAH.…”

Section: Methodsmentioning

confidence: 99%

“…It has been assumed that the decrease of sodium excretion (UNaV) is secondary to the decrease of GFR and that increased ureteral back pressure does not enhance tubular sodium reabsorption directly (2). The present study was directed toward the question of whether increased ureteral back pressure might have a direct effect on the renal tubular reabsorption of sodium, independent of any decrease of GFR.…”

Section: Introductionmentioning

confidence: 96%

“…Acute increases of ureteral back pressure in dogs usually cause decreases of glomerular filtration rate (GFR) and disproportionately larger decreases of sodium excretion (1)(2)(3). It has been assumed that the decrease of sodium excretion (UNaV) is secondary to the decrease of GFR and that increased ureteral back pressure does not enhance tubular sodium reabsorption directly (2).…”

Section: Introductionmentioning

confidence: 99%

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Increased ureteral back pressure enhances renal tubular sodium reabsorption

Fulop¹,

Brazeau²

1970

J. Clin. Invest.

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A B S T R A C T Moderate increases of ureteral back pressure usually cause decreases of glomerular filtration rate and even greater decreases of sodium excretion. It has been assumed previously that increased ureteral back pressure does not enhance renal tubular sodium reabsorption directly and that the decreases of sodium excretion are caused by the decreases of glomerular filtration rate. In the experiments reported here, the effect of increased ureteral back pressure on urinary-sodium excretion was studied in dogs in which changes of filtration rate were minimized by infusing saline while ureteral back-pressure was increased.When ureteral back pressure was increased on one side by 10-23 cm of water, the inulin clearance of the experimental kidney decreased by only 3-12% in 21 experiments, did not change significantly (±2%) in eight experiments, and increased by 3-8% in seven experiments. The sodium excretion of the experimental kidney decreased in al experiments regardless of whether its inulin clearance increased, decreased, or was unchanged from control values.When the inulin clearance of the experimental kidney increased or remained unchanged during increased ureteral back pressure, its reabsorption of sodium increased more than could be accounted for by the increase of filtered sodium. When the inulin clearance of the experimental kidney decreased during increased ureteral back pressure, its reabsorption of sodium decreased less than could be accounted for by the decrease of filtered sodium.Therefore, the effect of increased ureteral back pressure to decrease urinary sodium excretion is caused in part by increased tubular reabsorption of sodium.

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Section: Methodsmentioning

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Increased ureteral back pressure enhances renal tubular sodium reabsorption

Fulop¹,

Brazeau²

1970

J. Clin. Invest.

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show abstract

“…Organic anionic compounds have been shown to displace unconjugated bilirubin from plasma protein (21) Partial ureteral obstruction experiments were performed to dissociate GFR and RPF (25)(26)(27) in order to learn whether the CB changed concordantly with one or the other parameter. This technique is less drastic than the stop-flow method, and it has been shown not to interfere with tubular secretion of PAH (26) or phenol red (7). If bilirubin were secreted by the proximal tubules, changes in its clearance should correspond more closely with changes in RPF at excretory rates less than maximal rate of transport (Tm).…”

Section: The Renal Excretion Of Bilirubin In Dogs With Obstructive Jamentioning

confidence: 99%