Effects of Ultrasound-Assisted and Direct Solvent Extraction Methods on the Antioxidant and Antibacterial Properties of Saffron (Crocus sativus L.) Corm Extract

Esmaeelian, Mozhgan; Jahani, Moslem; Feizy, Javad; Einafshar, Soodabeh

doi:10.1007/s12161-020-01855-8

Cited by 14 publications

(8 citation statements)

References 65 publications

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“…Similarly, from Pistacia lentiscus leaves that obtaining a lower TPC value of 1420.76 ± 19.98 mgGAE/100 g [40]. More recently, Esmaeelian, et al [41] have shown a lower TPC value from Crocus sativus L. corms extract than our result (100.39 mgGAE/100 g dry saffron corm) using 80% of ethanol. The extraction process used in the present work give higher TPC than Indian jujube cultivars using conventional extraction method ranging from 172.08 to 328.65 mgGAE/100 g with 80% of ethanol [42].…”

Section: Effect Of Experimental Conditions On Tpc Tfc and Ttc Extracontrasting

confidence: 49%

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

et al. 2020

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Jujube plant is a potential source of polyphenols with biological propreties. The purpose of this study was to investigate the application of ultrasound technique for extracting phenolic compounds (TPC) from seeds of Zizyphus lotus under optimization conditions based on response surface methodology. A maximum TPC, total flavonoids content (TFC), and total condensed tannins content (TTC) of 2383.10 ± 0.87 mg GAE/100g, 486.50 ± 0.38 mg QE/100g and 15,787.10 ± 0.10 mg CE/100g, respectively obtained under ethanol concentration 50.16%, sonication temperature 29.01 °C, sonication time 15.94 min and solvent-to-solid ratio 34.10:1 mL/g. The optimized extract was then evaluated for its antioxidant, antiacethylcholinesterase, antihypercholesterolemia, and antiproliferative activities. The results showed that ultrasound method is a green and safe method that can be used to effectively extract TPC from jujube seeds. The biological activity of Zizyphus extract exhibited a very good antioxidant against DPPH (EC50 = 0.39 µg/mL) and FRAP (1670.42 ± 6.5 mg/100 g). Additionally, it possesses acetylcholinesterase (AChE) inhibitory effect (IC50 = 0.93 ± 0.01 mg/mL) and HMGR inhibition (45.41%) using 100 µg/mL. The extract significantly inhibits cell proliferation on the MCF-7 and HepG2 tumor cell lines with an IC50 values of <0.05 and 3 ± 0.55 mg/mL, respectively. Therefore, the ultrasound method can be considered a method for obtaining a significant anticancer activity with respect to the lines and therefore makes it possible to recover a maximum of phenolic compounds in less time with an AChE and HMGR inhibitory activity. Thus, it can be suggested that Zls extract is a promising fruit for the development of supplementary dietary due to its potential behaviour as nutraceutical.

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Section: Effect Of Experimental Conditions On Tpc Tfc and Ttc Extracontrasting

confidence: 49%

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

et al. 2020

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“…Likewise, bioactive constituents in saffron corm, such as proteoglycans, revealed to have a cytolytic effect on human tumor and plant cells and triterpenoid saponins on fungicidal and anticancer activities [30]. Polyphenols showing antibacterial, radical scavenging activity [39,40], and a mannan-binding lectin [41] have also been investigated in saffron corms. The existing experimental analysis aimed to explore the anti-inflammatory, analgesic, anticoagulant, and antidepressant potentials of various extracts of Crocus sativus L. in mice by carrageenan-induced paw edema test, hot plate assay, capillary method, and forced swim test, respectively.…”

Section: Introductionmentioning

confidence: 99%

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan

Muhamad

Ismail

et al. 2020

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Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate, carrageenan-induced paw edema, capillary tube and forced swim test, respectively in mice. The results indicated that among all the extracts, stigma ethanolic extract (SEE) represented maximum latency activity (72.85%) and edema inhibition (77.33%) followed by petal ethanolic extract (PEE) with latency activity and edema inhibition of 64.06 and 70.50%, respectively. Corm ethanolic extract (CEE) and leaf ethanolic extract (LEE) displayed mild analgesic activity of 22.40% and 29.07%, respectively. Additionally, LEE (53.29%) and CEE (47.47%) exhibited mild to moderate response against inflammation. The coagulation time of SEE (101.66 s) was almost equivalent to the standard drug, aspirin (101.66 s), suggesting a strong anticoagulant effect followed by PEE (86.5 s). LEE (66.83 s) represented moderate inhibitory effect on coagulation activity while CEE (42.83 s) showed neutral effect. Additionally, PEE and SEE also expressed itself as potential antidepressants with immobility time ≤76.66 s, while CEE (96.50 s) and LEE (106.83 s) indicated moderate to mild antidepressant efficacy. Based on the in vivo activities, saffron extract, particularly SEE and PEE, can be used as a potential nutraceutical and therapeutic agent due to its significant pharmacological activities.

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“…These contents, according to the 3D plot, first increased and then decreased with increasing ethanol concentrations; the same results were reported by. 24 The TPC and TFC values were highest when the extraction was performed with a temperature of 25 to 42.5 °C. While, the extracts obtained with the temperature 60 °C had the lowest TPC and TFC values.…”

Section: Analysis Of Response Surfacementioning

confidence: 94%

Extraction, Chemical Composition and Antioxidant Activity of Phenolic Compounds from Moroccan Satureja nepeta L.

EZAOUINE¹,

Salam²,

SBAOUI³

et al. 2022

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Ethanol, Quercetin was supplied by China Institute for Drugs and Biological Products Identification (Beijing, China), and the purity is over 98%. sodium carbonate, sodium nitrite, aluminum trichloride, anthrone, sulfuric acid, disodium phosphate Folin-Ciocalteu reagent and 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), ABTS (2,2′-Azinobis-(3ethylbenzthiazoline-6-sulfonic acid), ferric chloride (FeCl 3 ) and Ascorbic acid were purchased from Sigma (St. Louis, MO, USA). All the other reagents were of analytical grade, methanol and Formic acid (HPLC grade) were obtained from Merck (Darmstadt

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Effects of Ultrasound-Assisted and Direct Solvent Extraction Methods on the Antioxidant and Antibacterial Properties of Saffron (Crocus sativus L.) Corm Extract

Cited by 14 publications

References 65 publications

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Extraction, Chemical Composition and Antioxidant Activity of Phenolic Compounds from Moroccan Satureja nepeta L.

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