Extraction, Chemical Composition and Antioxidant Activity of Phenolic Compounds from Moroccan Satureja nepeta L.

EZAOUINE, A; Salam, Mohamed Rida; SBAOUI, Y; Nouadi, Badreddine; ZOUHIR, S; ELMESSAL, M; Chegdani, Fatima; Bennis, Faïza

doi:10.5530/pj.2022.14.24

Cited by 4 publications

(9 citation statements)

References 31 publications

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“…A previous study characterized the phenolic compounds of S. nepeta , for the aqueous extract by HPLC-UV. 1 Among the various compounds characterized by HPLC-UV (rutin, quercetin, catechin, caffeic acid, vanillic acid, ferulic acid, and gallic acid), we found that quercetin, catechin, and gallic acid were the 3 major compounds representing more than 60% of the total composition ( Table 1 ). These 3 compounds are known for their anti-inflammatory effect.…”

Section: Resultsmentioning

confidence: 88%

“…In fact, studies have demonstrated that the major active compounds of S. nepeta have significant therapeutic potential for inflammatory bowel diseases such as Crohn’s disease and irritable bowel syndrome. 1 , 28 …”

Section: Resultsmentioning

confidence: 99%

“…The chemical compounds of S. nepeta are previously characteri-zed by high performance liquid chromatography coupled to ultraviolet (HPLC-UV), 1 then identified in PubChem ( https://pubchem.ncbi.nlm.nih.gov ) and/or traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) ( http://lsp.nwu.edu.cn/tcmsp.php ) databases ( Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…S. nepeta , an excellent medicinal plant used by the Moroccan population is very rich in phenolic compounds, flavonoids, and tannins; 1 it also has certain biological properties, such as antimicrobial and antioxidant activity. In addition, recent experiments have confirmed their potent antiproliferative effects on human tumor lines as well as anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, recent experiments have confirmed their potent antiproliferative effects on human tumor lines as well as anti-inflammatory properties. 1 - 3 Interleukin-6 (IL-6), also known as interferon β2, is a key cytokine in the regulation of acute and long-term inflammation, and it is produced in response to infections. This pleiotropic cytokine produced by a variety of cell types (fibroblasts, keratinocytes, mesangial cells, vascular endothelial cells, mast cells, macrophages, dendritic cells, T and B lymphocytes) is the messenger between cells involved in the inflammation process.…”

Section: Introductionmentioning

confidence: 99%

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In Silico Prediction of the Bioactive Profile and Metabolites of Satureja nepeta in Diseases Related to the Excessive Production of Interleukin-6

EZAOUINE

Salam

Nouadi

et al. 2022

Bioinform Biol Insights

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Inflammatory bowel diseases are caused by an abnormal reaction of the immune system, which becomes hyperactive because the mechanisms responsible for regulating it get out of control. For an effective immune response, many proinflammatory cytokines are secreted, particularly interleukin-6 (IL-6) keystone cytokine inflammation. Many synthetic and natural compounds targeting IL-6 have been studied. The genus Satureja of the Lamiaceae family is generally known for its many virtues, in particular anti-inflammatory properties. However, the mechanism of action is unclear. This study aims to predict the impact of characterized bioactive molecules of Moroccan Satureja nepeta in the potential control of inflammatory response mediated by IL-6 cytokine. A list of 9 previously characterized natural compounds of S. nepeta was compiled, and a list of 6 potential protein targets involved in intestinal inflammation was made. The 2 lists of natural compound-target proteins were analyzed by the STITCH software ( http://stitch.embl.de/ ) to develop protein-compound and protein-protein interaction networks (PPINs). An ontological enrichment (GO) analysis was performed by the Clue GO plugin to evaluate the PPIN generated by STITCH; finally, the molecular docking to predict the mode underlying the anti-inflammatory effects. STITCH results revealed direct and indirect interactions of S. nepeta chemical compounds with a key protein target IL-6. The array results by ClueGO showed that most compounds involved in the regulation of several biological processes related to IL-6 such as inflammation apoptosis, cell differentiation, and metabolic regulation. The targets directly related to IL-6 have been used for molecular docking. Quercetin, catechin, and gallic acid have a strong affinity with the IL-6 receptor (respectively −7.1; −6.1; −5.3). This study strongly suggests that the bioactive compounds of S. nepeta could constitute a new therapeutic alternative in the treatment of diseases related to IL-6. However, to validate the results obtained in this work, it is necessary to explore the mechanism of action of potential bioactive molecules by experimentation.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%