Effects of two hemostatic agents on osseous healing

Haasch, Gregory C.; Gerstein, Harold; Austin, B.P.

doi:10.1016/s0099-2399(89)80053-6

Cited by 19 publications

(15 citation statements)

References 8 publications

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“…These findings confirm those obtained by other authors. 9,11 The results indicate that the haemostatic agents assessed in this study can be used in oral surgeries; however, there is a strong recommendation for the total removal of the material 5 to 10 minutes after application, because the presence of material residues can induce an inflammatory response.…”

Section: Discussionmentioning

confidence: 83%

“…11,20 Thus, small amounts of residual haemostatic agent material were observed in some specimens 7 and 14 days after surgery, but they neither induced an inflammatory response 8,9,14 nor harmed the osseous repair in the 30-and 45-day postoperative periods as they were resorbed.…”

Section: Discussionmentioning

confidence: 99%

“…8 A large number of studies have demonstrated that this material initially provokes an inflammatory response, though with no long-term side effects on osseous formation if completely removed. 9,11,14,21 Beriplast -a fibrin sealer compounded by fibrinogen, factor XIII and thrombin, all isolated from human plasma and lyophilized -has an effect based on the final stage of coagulation. 16,24 Its major components, human fibrinogen and thrombin, lead to the formation of a fibrin clot that is stable and insoluble in the presence of FXIII and calcium.…”

Section: Introductionmentioning

confidence: 99%

“…At times, the combination of suture and tissue sealers has demonstrated the best results. 19 Many studies carried out both in the periapical region 2,23,28,29 and in osseous tissue 1,[8][9][10][11]14,20 have demonstrated that if the haemostatic agents are inadvertently left in the surgical site they can induce an inflammatory process and affect tissue repair. 2,3,9,28 The objective of this study was to assess the effects of haemostatic agents on osseous repair in rat tibia, aiming to observe the presence of inflammatory cells and osseous tissue formation.…”

Section: Introductionmentioning

confidence: 99%

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Effects of fibrin sealer and resorbable gelatin on the repair of osseous defects in rat tibia

2007

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Efeitos de selante de fibrina e de gelatina absorvível no reparo de defeitos ósseos em tíbia de rato Abstract: Gelfoam  -a biologically resorbable gelatin sponge -has the function of restricting hemorrhage, providing platelet rupture, and supporting fibrin threads. Beriplast  -a fibrinogen-thrombin compound -is used to adhere tissues, to consolidate sutures and in hemostasis. The objective of this study was to perform a histological analysis of the effects of haemostatic agents on osseous repair. These materials were inserted into surgical sites in young rat right and left tibiae. After the observation periods of 7, 14, 30 and 45 days, according to the bioethic protocol, the animals were killed, the tibiae were removed and fixed in 10% formalin and decalcified in equal parts of formic acid and sodium citrate solutions. After routine processing, the specimens were embedded in paraffin for microtomy. Analysis of the results demonstrated that the haemostatic agents are effective in controlling hemorrhage; they stimulate osteogenesis, featuring a pattern of osseous tissue formation similar to the control pattern, although the amount of osseous trabeculae was superior, especially in the Gelfoam group in the periods of 7 and 14 days; 30 days after surgery, the delay in tissue healing in the control group in relation to the experimental groups started to decrease, and the control and experimental groups exhibited similar tissue repair after 45 days, when all the groups exhibited secondary osseous tissue. Descriptors: Fibrin foam; Fibrin tissue adhesive; Osteogenesis; Rats; Tibia. Resumo: Gelfoam -uma esponja de gelatina biologicamente reabsorvível -tem por função coibir as hemorragias, promover o rompimento de plaquetas e sustentar a rede de fibrina. Beriplast P  -um composto de fibrinogênio-trombina -é usado na adesão de tecidos, consolidação de suturas e hemostasia. O objetivo deste estudo foi verificar histologicamente os efeitos de agentes hemostáticos na reparação óssea, os quais foram colocados em lojas cirúrgicas nas tíbias direita e esquerda de ratos jovens. Após os perío-dos de observação de 7, 14, 30 e 45 dias, segundo o protocolo bioético, os animais foram sacrificados, as tíbias foram removidas e fixadas em formalina a 10% e descalcificadas em partes iguais de soluções de ácido fórmico e citrato de sódio, para inclusão em parafina e microtomia. A análise dos resultados demonstrou que os agentes hemostáticos têm eficá-cia no controle hemorrágico; eles estimulam a osteogênese, provocando um padrão de formação de tecido ósseo semelhante ao padrão do grupo controle, embora a quantidade de trabéculas ósseas tenha sido superior principalmente no grupo do Gelfoam, nos períodos de 7 e 14 dias; após os 30 dias da cirurgia, o retardo na reparação tecidual do grupo controle em relação aos grupos experimentais começou a decrescer, tornando-se a reparação tecidual daquele semelhante à destes aos 45 dias, quando todos os grupos apresentaram tecido ósseo secundário.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of fibrin sealer and resorbable gelatin on the repair of osseous defects in rat tibia

2007

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“…Gelatin was completely resorbed and healing was complete at 120 days [20]. MFC did not impair bone formation in rat tibias in the Haasch study of 1989 [16]. Alberius et al studied the effect of bone wax on rabbit cranial bone lesions.…”

Section: Animal Studiesmentioning

confidence: 99%