Effects of triclosan on reproductive prarmeters and embryonic development of sea urchin, Strongylocentrotus nudus

Hwang, Jinik; Suh, Sung-Suk; Chang, Man; Park, So Yun; Ryu, Tae Kwon; Lee, Sukchan; Lee, Taek-Kyun

doi:10.1016/j.ecoenv.2013.10.029

Cited by 31 publications

(10 citation statements)

References 28 publications

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“…(Brausch and Rand, 2011;Bedoux et al, 2012;Dann and Hontela, 2011;Hwang et al, 2014). It was found that TCS is highly toxic to algae (Roberts et al, 2014).…”

Section: Introductionmentioning

confidence: 97%

“…In addition to the acute toxicity testing, other studies about adverse effects of TCS and TCC (especially for TCS) on aquatic organisms mainly focused on the reproductive and developmental toxicity (Hwang et al, 2014;Marlatt et al, 2013), bioconcentration (Bedoux et al, 2012), or behavior disruptions (Fritsch et al, 2013;Schultz et al, 2012) and enzymes activity changes in detoxification and antioxidant systems (Hinther et al, 2011;Ku et al, 2014;Peng et al, 2013). Unfortunately, the profound toxic action mechanisms/pathways of TCS and TCC to aquatic organisms are still unclear and limited, particularly for the exposure of TCS and TCC at environmental concentrations.…”

Section: Introductionmentioning

confidence: 98%

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Effects of triclosan and triclocarban on the growth inhibition, cell viability, genotoxicity and multixenobiotic resistance responses of Tetrahymena thermophila

et al. 2015

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“…(Brausch and Rand, 2011;Bedoux et al, 2012;Dann and Hontela, 2011;Hwang et al, 2014). It was found that TCS is highly toxic to algae (Roberts et al, 2014).…”

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Effects of triclosan and triclocarban on the growth inhibition, cell viability, genotoxicity and multixenobiotic resistance responses of Tetrahymena thermophila

et al. 2015

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“…To date, the toxicological study using sea urchin has mainly focused on investigating individual heavy metal toxicity or pharmaceutical compounds on fertilization rate, embryolarval abnormality, and growth (Nadella et al 2013;Hwang et al 2014). Few data are available on the effects of contamination by a joint action of multiple trace metals and pharmaceutical compounds at cellular level, although some work has attempted to investigate the toxicity of multiple metals (Cu, Pb, Zn, and Cd) on the early embryo development stage of sea urchin (Xu et al 2011).…”

Section: Introductionmentioning

confidence: 98%

Assessment of the individual and mixture toxicity of cadmium, copper and oxytetracycline, on the embryo-larval development of the sea urchin Paracentrotus lividus

Gharred

Jebali

Belgacem

et al. 2016

Environ Sci Pollut Res

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Multiple pollutions by trace metals and pharmaceuticals have become one of the most important problems in marine coastal areas because of its excessive toxicity on organisms living in this area. This study aimed to assess the individual and mixture toxicity of Cu, Cd, and oxytetracycline frequently existing in the contaminated marine areas and the embryo-larval development of the sea urchin Paracentrotus lividus. The individual contamination of the spermatozoid for 1 h with the increasing concentrations of Cd, Cu, and OTC decreases the fertility rate and increases larvae anomalies in the order Cu > Cd > OTC. Moreover, the normal larva frequency and the length of spicules were more sensitive than the fertilization rate and normal gastrula frequency endpoints. The mixture toxicity assessed by multiple experimental designs showed clearly that concentrations of Cd, Cu, and OTC superior to 338 μg/L, 0.56 μg/L, and 0.83 mg/L, respectively, cause significant larva malformations.

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“…In our previous study, bioassays were carried out by assessing gamete viability and early embryonic development success in sea urchin in response to TCS. The data showed that TCS treatment could give rise to failure of normal embryonic development at an early stage (Hwang et al, ). However, there was no molecular evidence to explain the effect of TCS on sea urchin embryonic development.…”

Section: Discussionmentioning

confidence: 99%

Differential gene expression patterns during embryonic development of sea urchin exposed to triclosan

Hwang

Suh

Park

et al. 2016

Environmental Toxicology

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Triclosan (TCS; 2,4,4'-trichloro-2'-hydroxydiphenyl ether) is a broad-spectrum antibacterial agent used in common industrial, personal care and household products which are eventually rinsed down the drain and discharged with wastewater effluent. It is therefore commonly found in the aquatic environment, leading to the continual exposure of aquatic organisms to TCS and the accumulation of the antimicrobial and its harmful degradation products in their bodies. Toxic effects of TCS on reproductive and developmental progression of some aquatic organisms have been suggested but the underlying molecular mechanisms have not been defined. We investigated the expression patterns of genes involved in the early development of TCS-treated sea urchin Strongylocentrotus nudus using cDNA microarrays. We observed that the predominant consequence of TCS treatment in this model system was the widespread repression of TCS-modulated genes. In particular, empty spiracles homeobox 1 (EMX-1), bone morphogenic protein, and chromosomal binding protein genes showed a significant decrease in expression in response to TCS. These results suggest that TCS can induce abnormal development of sea urchin embryos through the concomitant suppression of a number of genes that are necessary for embryonic differentiation in the blastula stage. Our data provide new insight into the crucial role of genes associated with embryonic development in response to TCS. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 426-433, 2017.

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Effects of triclosan on reproductive prarmeters and embryonic development of sea urchin, Strongylocentrotus nudus

Cited by 31 publications

References 28 publications

Effects of triclosan and triclocarban on the growth inhibition, cell viability, genotoxicity and multixenobiotic resistance responses of Tetrahymena thermophila

Effects of triclosan and triclocarban on the growth inhibition, cell viability, genotoxicity and multixenobiotic resistance responses of Tetrahymena thermophila

Assessment of the individual and mixture toxicity of cadmium, copper and oxytetracycline, on the embryo-larval development of the sea urchin Paracentrotus lividus

Differential gene expression patterns during embryonic development of sea urchin exposed to triclosan

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