Effects of treatment with estrogen and progesterone on the methamphetamine-induced cognitive impairment in ovariectomized rats

Ghazvini, Hamed; Khaksari, Mohammad; Esmaeilpour, Khadijeh; Shabani, Mohammad; Asadi-Shekaari, Majid; Khodamoradi, Mehdi; Sheibani, Vahid

doi:10.1016/j.neulet.2016.02.057

Cited by 40 publications

(21 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The path length and escape latency to discover the platform were examined to assess spatial learning. The animals’ performance was measured using a video tracking system (Noldus Ethovision® system, version 5, USA) ( Ghazvini et al, 2016 ; Hajali et al, 2015 ; Saadati et al, 2015 ).…”

Section: Methodsmentioning

confidence: 99%

Effects of Hydroalcoholic Extract of Soy on Learning, Memory and Synaptic Plasticity Deficits Induced by Seizure in Ovariectomized Rats

Khodamoradi

Asadi-Shekaari

Esmaeili‐Mahani

et al. 2017

BCN

Self Cite

View full text Add to dashboard Cite

Introduction:Previous studies have shown that seizure can induce cognitive impairment. On the other hand, soy phytoestrogens, which are mainly found in soybean (Glycine max (L.) Merr.), have beneficial effects on the nervous system. However, little is known about their probable effects on seizure. The present study aimed to examine the probable effects of soy extract, containing the phytoestrogen genistein on seizure-induced cognitive and synaptic plasticity impairment in Ovariectomized (OVX) rats.Methods:Rats were ovariectomized, implanted with guide cannula and then divided into 5 groups (n=7–8 in each group): PBS, KA, Saline-KA, Higher Dose Soy (HDS-KA), and Lower Dose Soy (LDS-KA) groups. Animals of the HDS-KA and LDS-KA groups received intraperitoneal administration of soy extract (20 and 2 mg/kg, respectively) and the Saline-KA group received normal saline once a day for 4 days. Sixty minutes after the last injection, Kainic Acid (KA) or PBS was injected into the left lateral ventricle via pre-implanted guide cannula to induce generalized seizures. The Morris water maze task and in vivo field potential recordings were conducted 7 days later.Results:Soy extract at both doses significantly improved learning impairment and at the higher dose (20 mg/kg) significantly prevented seizure-induced spatial memory impairment and deficit of long-term potentiation in the hippocampus.Conclusion:The soy extract containing the phytoestrogen genistein may have beneficial effects on memory deficit induced by seizure in OVX rats and this effect is accompanied by a beneficial effect on synaptic plasticity.

show abstract

Section: Methodsmentioning

confidence: 99%

Effects of Hydroalcoholic Extract of Soy on Learning, Memory and Synaptic Plasticity Deficits Induced by Seizure in Ovariectomized Rats

Khodamoradi

Asadi-Shekaari

Esmaeili‐Mahani

et al. 2017

BCN

Self Cite

View full text Add to dashboard Cite

show abstract

“…It was shown that a neurotoxic regimen of METH not only induced damage at cellular levels but also impaired the performance or the rats in the novel object-recognition task and multiple T-water-maze test of path integration [29]. It was reported that both the neurotoxic METH regimen and METH withdrawal after 14 days could result in memory deficit and impairment of hippocampal synaptic plasticity (long-term potentiation [LTP]) [3,7]. It is worth noting that hippocampal LTP has been introduced as a model for memory [31].…”

Section: Groupsmentioning

confidence: 99%

“…A s a potent psychostimulant associated with extensive adverse effects on the nervous system, methamphetamine (METH) is being increasingly abused throughout the world, thus imposing a serious health concern on the world's population [1,2]. As increasingly mentioned in the literature, METH abusers are at a high risk of learning and memory impairment in the form of long-term cognitive dysfunction [3][4][5][6]. Accordingly, animal studies have shown that the chronic or toxic METH regimen can produce severe impairments in hippocampaldependent tasks, particularly those of spatial memory [7].…”

Section: Introductionmentioning

confidence: 99%

“…As increasingly mentioned in the literature, METH abusers are at a high risk of learning and memory impairment in the form of long-term cognitive dysfunction [3][4][5][6]. Accordingly, animal studies have shown that the chronic or toxic METH regimen can produce severe impairments in hippocampaldependent tasks, particularly those of spatial memory [7]. It is also worthy of note that METH administration may induce hyperthermia, a condition which may lead to memory impairment [8,9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats

Khalifeh

Khodamoradi

Hajali

et al. 2019

GMJ

Self Cite

View full text Add to dashboard Cite

Background: Methamphetamine (METH) as a synthetic psychostimulant is being increasingly recognized as a worldwide problem, which may induce memory impairment. On the other hand, it is well established that naloxone, an opiate antagonist, has some beneficial effects on learning and memory. The present research aimed at evaluating naloxone effects on spatial learning and memory impairment triggered by a neurotoxic regimen of METH in male rats. Materials and Methods: The animals received the subcutaneous (sc) regimen of METH (4×6 mg/kg at 2-h intervals), intraperitoneal (ip) naloxone (4×1 mg/kg at 2-h intervals), or normal saline at four events. The Nal-METH group of rats received four naloxone injections (1 mg/kg, ip) 30 min before each METH injection (6 mg/kg, sc) at 2-h intervals. Seven days later, they were evaluated for spatial learning and memory in the Morris Water Maze (MWM) task. Result: METH regimen induced hyperthermia, as well as a poor performance, in the acquisition and retention phases of the task, indicating spatial learning and memory impairment compared to the controls. Naloxone administration (1 mg/kg, ip) before each METH injection led to significant attenuations of both hyperthermia and METH adverse effects on the rat performance in the MWM task. Conclusion: The results revealed that pretreatment with the opiate antagonist naloxone could prevent METH adverse effects on body temperature and memory performance. It seems that the opioidergic system and hyperthermia may, at least partially, be involved in METH effects on spatial memory. [GMJ. 2019;8:e1182]

show abstract

“…Patients with depression tend to have neuroendocrine dysregulation, which includes a hyperactive hypothalamic-pituitary-adrenal axis (HPA) and non-suppression of cortisol by dexamethasone [15]. Furthermore, many neuroendocrine hormones dysregulation, including hormones of the hypothalamus-pituitary-adrenal (HPA) axis, hypothalamus-pituitary-thyroid (HPT) axis, and hypothalamus-pituitary-gonadal (HPG) axis were associated and correlated with impaired cognitive performance in different medical disorders [16][17][18][19][20][21][22][23][24][25][26]. In addition, growing evidence indicated that corticotropin releasing hormone (CRH) involved in learning and memory.…”

Section: Introductionmentioning

confidence: 99%

Cognitive performance in patients with chronic tension-type headache and its relation to neuroendocrine hormones

Kotb

Kamal

Almalki

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

Background: Tension-type headache is the most common headache to be seen in clinical practice. Depression is highly prevalent in chronic tension-type headache (CTTH) patients attending the clinical settings. Cognitive impairment and neuroendocrine dysregulation had been reported in patients with depression and patients with CTTH. Objective: To assess the cognitive performance and investigate its possible relations to neuroendocrine levels in patients with CTTH. Subjects and methods: Patients with CTTH, depression, and control subjects were recruited. CTTH was diagnosed according to the International Classification of Headache Disorders. Cognitive performance, depression severity, and pain intensity were assessed by the Montreal Cognitive Assessment Arabic version, Beck's Depression Inventory, and McGill Pain Questionnaire respectively. Blood samples were collected in the morning within 60 min after waking up from 8:00 to 9:00 a.m. to measure serum levels of basal plasma CRH, ACTH, Cortisol, TSH, FT3, and FT4. Results: Both patients with CTTH and depression had impaired cognitive performance. Patients with CTTH and patients with depression had altered the hypothalamus-pituitary-adrenal axis, and pituitary-thyroid axis. The hormonal levels significantly correlated with cognitive function in patient groups, especially patients with CTTH. Conclusion: Patients with CTTH had cognitive dysfunction which could be related to neuroendocrine hormonal dysregulation.

show abstract

Effects of treatment with estrogen and progesterone on the methamphetamine-induced cognitive impairment in ovariectomized rats

Cited by 40 publications

References 68 publications

Effects of Hydroalcoholic Extract of Soy on Learning, Memory and Synaptic Plasticity Deficits Induced by Seizure in Ovariectomized Rats

Effects of Hydroalcoholic Extract of Soy on Learning, Memory and Synaptic Plasticity Deficits Induced by Seizure in Ovariectomized Rats

Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats

Cognitive performance in patients with chronic tension-type headache and its relation to neuroendocrine hormones

Contact Info

Product

Resources

About