Effects of topical phenytoin on nasal wound healing after mechanical trauma: An experimental study

Şimşek, Gökçe; Çiftçi, Osman; Karadağ, Neşe; Karataş, Erkan; Kızılay, Ahmet

doi:10.1002/lary.24811

Cited by 27 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nasal surgery is an important procedure in the treatment of nasal diseases. Especially, ESS has been the most effective treatment for patients with pathological problems in the sino-nasal structure during the past 2 decades 13 . Therefore, it was performed in patients with sino-nasal disease refractory to medication.…”

Section: Discussionmentioning

confidence: 99%

Non-thermal plasma treated solution with potential as a novel therapeutic agent for nasal mucosa regeneration

Won

Kang

Kim

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Adequate and rapid mucosal regeneration is one of the most important factors in the healing process of nasal mucosa after surgery or trauma. In particular, delayed mucosal regeneration after surgery is an important cause of surgical failure. However, no effective treatment is available yet. Non-thermal plasma (NTP) has several medical effects, but the existing probe type is limited to local direct treatment. Therefore, we investigated the various effects using liquid type plasma to overcome this limitation. In addition, the therapeutic effects of non-thermal plasma treated solution (NTS) on nasal mucosa have yet to be determined. Experiments were carried out using BEAS-2B, a human bronchial epithelial cell line similar to nasal mucosa epithelium. NTS had no cytotoxicity to the BEAS-2B cells and enhanced cell proliferation. NTS also promoted migration of BEAS-2B cells. NTS increased cell proliferation and migration via epidermal growth factor receptor (EGFR) activities and epithelial-to-mesenchymal transition (EMT) signaling. Furthermore, NTS enhanced wound healing of nasal mucosa in an animal model. Accordingly, NTS promotes nasal mucosa wound healing by increasing cell proliferation and migration. These findings suggest the therapeutic potential of NTS in nasal mucosa wound healing.

show abstract

Section: Discussionmentioning

confidence: 99%

Non-thermal plasma treated solution with potential as a novel therapeutic agent for nasal mucosa regeneration

Won

Kang

Kim

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Wounds (in rat models) treated with topical phenytoin, tissue edema, and inflammatory cell infiltration were significantly decreased; epidermal growth factor, vascular endothelial growth factor, and transforming growth factor-β were significantly increased 33,34…”

Section: Discussionmentioning

confidence: 99%

Topical phenytoin for the treatment of neuropathic pain

Kopsky¹,

Hesselink

2017

JPR

View full text Add to dashboard Cite

We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects, such as burning, and analgesic patches (e.g., lidocaine 5% patches) have complex handling, especially for geriatric patients. Only in a few countries, compounded creams based on tricyclic antidepressants or other (co-)analgesics are available. Such topical analgesic creams, however, are easy to administer and have a low propensity for inducing side effects. We, therefore, developed a new topical cream based on 5% and 10% phenytoin and described three successfully treated patients suffering from neuropathic pain. All patients were refractory to a number of other analgesics. In all patients, phenytoin cream was effective in reducing pain completely, without any side effects, and the tolerability was excellent. The onset of action of the phenytoin creams was within 30 minutes. Phenytoin cream might become a new treatment modality of the treatment of neuropathic pain.

show abstract

“…When the wound healing accelerated, cellular proliferation increased as well. These proliferative cells are stained more intensively by anti-PCNA than are other cells [ 46 – 49 ]. PCNA immunostaining was much lower in the untreated ileostomy group than in the treatment groups.…”

Section: Discussionmentioning

confidence: 99%

Use of Ozone to Treat Ileostomy Dermatitis in an Experimental Rat Model

et al. 2016

View full text Add to dashboard Cite

BackgroundDermatitis associated with ileostomy is an important problem that affects many people, especially children. The aim of this study was to investigate the therapeutic effects of ozone on dermatitis due to ileostomy, and to develop an alternative treatment option.Material/MethodsA total of 28 rats were divided into 4 groups: control, ileostomy, ozone, and zinc oxide. Ileostomy was performed in all rats except the control group. After a 1-week waiting time, the ozone group was administered ozone therapy and the zinc oxide group was administered zinc oxide cream locally once a day for a total of 7 days. All rats were sacrificed at the end of this period. The efficacy of treatment was examined by biochemical, histopathological, and immunohistochemical parameters. The levels of malondialdehyde (MDA), total glutathione (tGSH), total antioxidant capacity (TAC), and total oxidant status (TOS) were measured from tissue. Vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) were examined immunohistochemically.ResultsDermatitis occurred pathologically in all rats that underwent ileostomy surgery. The lowest dermatitis score was in the ozone treatment group (p<0.05). Ileostomy dermatitis caused increased levels of MDA and TOS. Ozone treatment resulted in reduced MDA and TOS levels, while the levels of tGSH and TAC were increased (p<0.05). Both VEGF and PCNA immunostaining were augmented in the ozone treatment group (p<0.05).ConclusionsLocal ozone application may be a good alternative compared to the conventional treatment methods for the prevention of skin lesions that develop after ileostomy.

show abstract

Effects of topical phenytoin on nasal wound healing after mechanical trauma: An experimental study

Abstract: NA.

Cited by 27 publications

References 28 publications

Non-thermal plasma treated solution with potential as a novel therapeutic agent for nasal mucosa regeneration

Non-thermal plasma treated solution with potential as a novel therapeutic agent for nasal mucosa regeneration

Topical phenytoin for the treatment of neuropathic pain

Use of Ozone to Treat Ileostomy Dermatitis in an Experimental Rat Model

Contact Info

Product

Resources

About