Effects of Topical Instillation of Traditional Herbal Medicines, Herbal Extracts, and Their Components on Prostaglandin E2-induced Aqueous Flare Elevation in Pigmented Rabbits

Nagaki, Yasunori

doi:10.1016/s0021-5155(03)00002-9

Cited by 12 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Crocin was reported to have an anti-inflammatory effect in some models of inflammation induction (Ma, 1998). In a study by Nagaki et al (2003), intravenous injection of crocetin inhibited the LPS-induced aqueous flare elevation and partially prevented prostaglandin E2 (PGE2) induced aqueous flare elevation in rabbits. Arabian et al (2009) reported that aqueous extract of saffron inhibited formalin-induced paw edema in the chronic but not acute phase of a formalin test.…”

Section: Antinociceptive and Anti-inflammatory Effectsmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Effects of Crocus sativus L. (Saffron)

Amin

Hosseinzadeh

2015

Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease

View full text Add to dashboard Cite

Section: Antinociceptive and Anti-inflammatory Effectsmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Effects of Crocus sativus L. (Saffron)

Amin

Hosseinzadeh

2015

Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease

View full text Add to dashboard Cite

Laser flare-cell photometer: principle and significance in clinical and basic ophthalmology

Sawa

2016

Jpn J Ophthalmol

View full text Add to dashboard Cite

A slit-lamp examination is an indispensable and essential clinical evaluation method in ophthalmology, but, it is qualitative subjective. To complement its weaknesses in making a quantitative evaluation of flare intensity and number of cells in the aqueous humor in the eye, we invented the laser flare-cell photometer in 1988. The instrument enables a non-invasive quantitative evaluation of flare intensity and number of cells in the aqueous with good accuracy and repeatability as well as maneuverability equal to slit-lamp microscopy. The instrument can elucidate the pathophysiology in the blood-aqueous barrier (BAB) function in a variety of ocular disorders. The accuracy of the instrument makes it possible to investigate not only the pathophysiology of intraocular disorders but also the effects of various drugs and surgical procedures in BAB. The instrument does not only lighten the burden on patients in clinical examinations and study but it also helps minimize the sacrifice of experimental animals and improves the reliability of the results by minimizing inter-individual variations through its good repeatability. Here I shall relate how the instrument has been applied to clinical and basic studies in ophthalmology and what novel knowledge its application contributed to pathophysiology in ophthalmology.

show abstract