Analgesic and Anti-Inflammatory Effects of Crocus sativus L. (Saffron)

Amin, Bahareh; Hosseinzadeh, Hossein

doi:10.1016/b978-0-12-411462-3.00033-3

Cited by 14 publications

(7 citation statements)

References 48 publications

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“…Anti-viral, Immunomodulatory, Antinociceptive, antihypertensive, Anticonvulsant, Antitussive, Antigenototoxic, cytotoxic, Anxiolytic, anti-inflammatory, Anti-Alzheimer effect [84][85][86][87][88][89][90][91][92][93] ISSN: 2250-1177…”

Section: Sibr (Aloe Barbadensis)mentioning

confidence: 99%

Unani perspective on COVID-19 and the possible role of Tiryaq Wabai in its management: A Review

Aleem

Khan

Danish³

et al. 2021

J. Drug Delivery Ther.

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Science has uncovered much about SARS-CoV-2 and made extraordinary and unprecedented progress on the development of COVID-19 vaccines, but there is still great uncertainty as the pandemic continues to evolve. We are simply moving to a new phase of the pandemic. Tiryaq Wabai, is on the polyherbal medicine used for centuries by Unani doctors as preventative medicine in epidemics. It consists of three ingredients: Sibr (Aloe barbadensis), Zafran (Crocus sativus), and Mur-Makki (Commiphora myrrh). All the three ingredients of Tiryaq Wabai have various pharmacological activities like immunomodulatory, antitussive, expectorant, and antiviral activity which provide a strong basis for its prophylactic use for covid-19 infection. Further, research on this important prophylactic Unani formulation Tiryaq Wabai in Covid-19 is the need of the hour. Keywords: Tiryaq; Epidemic; Covid-19; Unani medicine

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Section: Sibr (Aloe Barbadensis)mentioning

confidence: 99%

Unani perspective on COVID-19 and the possible role of Tiryaq Wabai in its management: A Review

Aleem

Khan

Danish³

et al. 2021

J. Drug Delivery Ther.

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“…Corms also are a rich source of phenolic, flavonoid, and especially saponin (RubioMoraga et al, 2013), likely to participate in increased growth characteristics of the treated plants in the results of current research. Saffron stigmas contain nitroge nous substances, anthocyanins, glycosides, monoter penes, aldehydes, flavonoids, vitamins, volatile oils, proteins, carbohydrates (Amin and Hosseinzadeh, 2015). Also, some studies indicated the presence of micronutrients in saffron such as Zn, Mn, and certain amino acids (Priscila del Campo et al, 2009;D'Archivio et al, 2014), which favored the develop ment of the plant height and that the current results strongly corroborated with our previous study (Khoulati et al, 2019) with a concentration of 0.6 g/L, which contains 110.73 mg/L of crocin, 2.93 mg/L of safranal, and 37.45 mg/L of picrocrocin in the extract used in this study.…”

Section: Photosynthetic Pigmentsmentioning

confidence: 99%

“…Many researchers have focused their attention on valuing saffron byproducts to increase crop profitability, such as floral bioresidues and corms (Lahmass et al, 2018). The enhancement of these properties of saffron floral bioresidues was evaluated on the antioxidant activity (Sanchez Vioque et al, 2012), the antiinflammatory activity (Amin and Hosseinzadeh, 2015), the antifungal and cytotoxic activity (Zheng et al, 2011), and antibacter ial activity (Shadmehri et al, 2019). On the other hand, the tepals are used in many industries, as active ingredients in various food (Tuberoso et al 2016), in cosmetic formulations (Natalia et al, 2019), and as a potential resource of natural color thanks to the high content of anthocyanins for food applica tions, and biomedical (Shadmehri et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Impact of Moroccan Crocus sativus L. tepals, corms, and stigmas extract on growth and photosynthetic pigments in tomato seedling

Khoulati¹,

Saalaoui²

2021

Adv. Hort. Sci.

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An experiment was carried out in a greenhouse to study the effect of aqueous extracts of Crocus sativus L. by-products on tomato plants. Three concentrations of tepals and corms were used by fertigation: 1 g/L, 2 g/L, and 3 g/L. The aqueous extract of the stigmas was used as a foliar application at 0.6 g/L. The experiment was carried out in a completely randomized block with three repetitions for each concentration. The concentration of tepal extract at 3 g/L significantly (p≤0.05) increased the plants' height, the chlorophyll a, b content. The same results were observed for the foliar treatment with stigmas; however, there was no effect of tepal extract on the carotenoid content. On the other hand, the concentration 2 g/L of the corms extract had a positive impact (p≤0.05) in the chlorophyll b content while the concentration of 3 g/L increased the plant's height, the chlorophyll a (p≤0.05). Current results indicate that Crocus sativus by-products could improve certain physiological aspects of the recipient plants and new and natural biostimulants.

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“…Saffron, in particular, is the dried stigma of the flowers of Crocus sativus L. (family Iridaceae), cultivated mainly in Southern Europe, India and Iran, and is considered as one of the most expensive culinary spices globally [8]. The medicinal properties of saffron and its constituents (safranal, crocin, and crocetin) include anti-inflammatory, antioxidant, analgesic, antihypertensive, hypolipidemic, antitussive, anticonvulsant, antidepressant, anxiolytic, anticancer, and antinociceptive characteristics [9][10][11][12][13][14][15]. Nevertheless, although saffron supplementation has been tested in patients with various RDs employing a randomized controlled trial (RCT) design, we have insufficient evidence regarding its efficacy, as no systematic reviews have attempted to synthetize these data in order to aid in the formulation of recommendations.…”

Section: Introductionmentioning

confidence: 99%

Effect of Crocus sativus (Saffron) Intake on Top of Standard Treatment, on Disease Outcomes and Comorbidities in Patients with Rheumatic Diseases: Synthesis without Meta-Analysis (SWiM) and Level of Adherence to the CONSORT Statement for Randomized Controlled Trials Delivering Herbal Medicine Interventions

et al. 2021

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Rheumatic diseases (RDs) are often complicated by chronic symptoms and frequent side-effects associated with their treatment. Saffron, a spice derived from the Crocus sativus L. flower, is a popular complementary and alternative medicine among patients with RDs. The present systematic review aimed to summarize the available evidence regarding the efficacy of supplementation with saffron on disease outcomes and comorbidities in patients with RD diagnoses. PubMed, CENTRAL, clinicaltrials.gov and the grey literature were searched until October 2021, and relevant randomized controlled trials (RCTs) were screened for eligibility using Rayyan. Risk of bias was assessed using the Cochrane’s Risk of Bias-2.0 (RoB) tool. A synthesis without meta-analysis (SWiM) was performed by vote counting and an effect direction plot was created. Out of 125 reports, seven fulfilled the eligibility criteria belonging to five RCTs and were included in the SWiM. The RCTs involved patients with rheumatoid arthritis, osteoarthritis and fibromyalgia, and evaluated outcomes related to pain, disease activity, depression, immune response, inflammation, oxidative stress, health, fatigue and functional ability. The majority of trials demonstrated some concerns regarding overall bias. Moreover, the majority of trialists failed to adhere to the formula elaborations suggested by the CONSORT statement for RCTs incorporating herbal medicine interventions. Standardization of herbal medicine confirms its identity, purity and quality; however, the majority of trials failed to adhere to these guidelines. Due to the great heterogeneity and the lack of important information regarding the standardization and content of herbal interventions, it appears that the evidence is not enough to secure a direction of effect for any of the examined outcomes.

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Analgesic and Anti-Inflammatory Effects of Crocus sativus L. (Saffron)

Cited by 14 publications

References 48 publications

Unani perspective on COVID-19 and the possible role of Tiryaq Wabai in its management: A Review

Unani perspective on COVID-19 and the possible role of Tiryaq Wabai in its management: A Review

Impact of Moroccan Crocus sativus L. tepals, corms, and stigmas extract on growth and photosynthetic pigments in tomato seedling

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