Effects of three different low-intensity exercise interventions on physical performance, muscle CSA and activities of daily living: A randomized controlled trial

Benavent-Caballer, Vicent; Rosado-Calatayud, Pedro; Segura‐Ortí, Eva; Cuenca, Juan; Lisón, Juan Francisco

doi:10.1016/j.exger.2014.08.004

Cited by 52 publications

(83 citation statements)

References 48 publications

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“…Resistance exercise appears to decrease TNF-α expression in aged skeletal muscle, which may attenuate age-associated muscle changes [110]. Finally, exercise induced favorable skeletal muscle angiogenesis and improved endothelial function in elderly individuals [111, 112]. …”

Section: Physical Exercisementioning

confidence: 99%

Skeletal muscle aging: influence of oxidative stress and physical exercise

et al. 2017

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Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencies are involved in the physiopathology of muscle changes. Sarcopenia is characterized by structural, biochemical, molecular and functional muscle changes. An imbalance between anabolic and catabolic intracellular signaling pathways and an increase in oxidative stress both play important roles in muscle abnormalities. Currently, despite the discovery of new targets and development of new drugs, nonpharmacological therapies such as physical exercise and nutritional support are considered the basis for prevention and treatment of age-associated muscle abnormalities. There has been an increase in information on signaling pathways beneficially modulated by exercise; nonetheless, studies are needed to establish the best type, intensity, and frequency of exercise to prevent or treat age-induced skeletal muscle alterations.

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Section: Physical Exercisementioning

confidence: 99%

Skeletal muscle aging: influence of oxidative stress and physical exercise

et al. 2017

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“…Tables 1 and 2 give an overview of clinical trials using potential treatments of muscle wasting or including measurement of body composition in ageing ( Table 1) and in patients with CHF ( Table 2), which are often similar. 54 Endurance exercise seems to improve muscle quality more than muscle quantity. There is discussion about the best way of muscle training.…”

Section: Currently Available Treatment Strategies Targeting Muscle Fumentioning

confidence: 99%

“…57 Among 60 patients and 30 control subjects, they found both parameters to be reduced by 46% and 23%, respectively. [51][52][53][54] In daily clinical practice, in addition to exercise training, patients' nutrition should be optimized to prevent nutritional lack of protein and micronutrients. A pilot study on 27 patients with CHF showed that combined aerobic training with resistance training and inspiratory muscle training resulted in incremental benefits in both peripheral and respiratory muscle weakness, cardiopulmonary function, and quality of life compared with that of aerobic training alone.…”

Section: Currently Available Treatment Strategies Targeting Muscle Fumentioning

confidence: 99%

Muscle wasting in ageing and chronic illness

et al. 2015

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Present approaches to muscle wasting disease include exercise training, nutritional support, and drugs, although particularly the latter remain currently restricted to clinical studies. Optimizing skeletal muscle mass and function in ageing and chronic illness including heart failure is one of the chapters that are far from finished and gains future potential for new therapeutic interventions to come.

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“…As reported in several studies, EMS improves muscle mass and muscle function without altering abdominal and total body fat content, thus enhancing gait and quality of life . For example, a 4 month EMS intervention period (in total 48 sessions) in subjects >75 years resulted in an increase of rectus femoris cross‐sectional area by around 30% . Molecular wise EMS stimulates not only anabolic pathways (e.g.…”

Section: Human Datamentioning

confidence: 87%

Electromyostimulation to fight atrophy and to build muscle: facts and numbers

Adams

2018

J cachexia sarcopenia muscle

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In recent years, electrical myostimulation (EMS) is becoming more and more popular to increase muscle function and muscle weight. Especially it is applied in healthy individual after injury to rebuild muscle mass and in severely atrophic patients who are not able or willing to perform conventional exercise training programs. Studies in experimental models as well as in human subjects confirmed that EMS can increase muscle mass by around 1% and improve muscle function by around 10–15% after 5–6 weeks of treatment. Despite a severe increase in circulating creatine kinase during the first session, EMS can be regarded as a safe therapeutic intervention. At the molecular level, EMS improves the anabolic/catabolic balance and stimulates the regenerative capacity of satellite cells. EMS intensity should be as high as individually tolerated, and a minimum of three sessions per week [large pulses (between 300–450 μs), high frequency (50–100 Hz in young and around 30 Hz in older individuals)] for at least 5–6 weeks should be performed. EMS improved functional performances more effectively than voluntary training and counteracted fast type muscle fibre atrophy, typically associated with sarcopenia. The effect of superimposing EMS on conventional exercise training to achieve more muscle mass and better function is still discussed controversially. Nevertheless, EMS should not be regarded as a replacement of exercise training per se, since the beneficial effect of exercise training is not just relying on building muscle mass but it also exerts positive effects on endothelial, myocardial, and cognitive function.

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Effects of three different low-intensity exercise interventions on physical performance, muscle CSA and activities of daily living: A randomized controlled trial

Cited by 52 publications

References 48 publications

Skeletal muscle aging: influence of oxidative stress and physical exercise

Skeletal muscle aging: influence of oxidative stress and physical exercise

Muscle wasting in ageing and chronic illness

Electromyostimulation to fight atrophy and to build muscle: facts and numbers

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