Effects of Thiamin and Methionine Administration in Preventing Cadmium-Induced Biochemical Alterations and Metal Concentration in Male Rats

Gubrelay, Udita; Srivastava, Prabhat Kumar; Mathur, R.; Tripathi, Neelima; Flora, S.J.S.

doi:10.1016/s0946-672x(98)80030-8

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Chemical complex formation of thiamine with cadmium (Casas et al, ) and lead (Reddy et al, ) has been documented. Facilitated intestinal absorption and tissues uptake of lead by thiamine in rats was described by Sasser et al (), but several authors have shown thiamine may play a role as a heavy metals detoxification factor (Gubrelay et al, ; Tandon and Prasad, ). Therefore, thiamine and others vitamins could promote rapid release of heavy metals in tissues, the levels of cadmium and lead could appear increased in blood and subsequently be eliminated by urine.…”

Section: Discussionmentioning

confidence: 93%

Nutrients intake as determinants of blood lead and cadmium levels in Colombian pregnant women

Suárez‐Ortegón

Mosquera

Caicedo

et al. 2013

American J Hum Biol

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Possible acute and late effects of nutrients intake in blood lead and cadmium levels could be related with associations exclusively observed in the first and third trimester. This study represents the first exploration of relationships among a wide range of nutrients intake in the first trimester of pregnancy with blood lead and cadmium in first and third trimester of gestation. Further studies are required to confirm the findings mentioned herein.

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Section: Discussionmentioning

confidence: 93%

Nutrients intake as determinants of blood lead and cadmium levels in Colombian pregnant women

Suárez‐Ortegón

Mosquera

Caicedo

et al. 2013

American J Hum Biol

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“…In this study, supplementation of vitamins and essential minerals through nuts may be the reason for the observed attenuation of cadmium-induced neurotoxicity. Gubrelay et al (1998) showed the preventive effects of thiamin against cadmium-induced biochemical alteration in male rats. This group suggested the formation of an excretable thiamin-cadmium complex which reduced cadmium intoxication in male rats.…”

Section: Discussionmentioning

confidence: 99%

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

Batool¹,

Agha²,

Tabassum³

et al. 2019

Acta Neurobiologiae Experimentalis

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Cadmium, a heavy metal with no physiological function in the human body, is considered a bio-hazard. It is also considered to be a potent neurotoxin. The primary sources of cadmium exposure are diet and cigarette smoke. It has been postulated that nutritional deficiencies can increase the risk of cadmium toxicity. Nuts provide essential nutrients which are necessary for the maintenance of brain health in humans. The present study was designed to investigate the possible protective effects of almond and walnut supplementation on cadmium-induced neurotoxicity. Cadmium was orally administered at a dose of 50 mg/kg weekly with or without the supplementation of almond and walnut in rats. Intensities of depression-and anxiety-related behaviors were assessed by the forced swim test and light/dark transition test, respectively. Memory function was also evaluated by the elevated plus maze, Morris water maze and novel object recognition task. After four weeks of treatment it was observed that cadmium administration significantly induced depressogenic and anxiogenic behaviors. Memory function was also impaired by cadmium administration. Cadmium-treated rats exhibited reduced noradrenalin, dopamine and serotonin levels in the brain, whereas the levels of their respective metabolites were significantly increased. The dietary supplementation of almond and walnut at a dose of 400 mg/kg/day significantly attenuated cadmium-induced depression, anxiety and memory impairments. Neurochemical aberrations also normalized following supplementation with these nuts in rats. The present study demonstrates that long-term supplementation with almond and walnut provides essential nutrients which may overcome nutritional deficiencies and thereby reduce heavy-metal intoxication.

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Metal toxicity and natural antidotes: prevention is better than cure

Rajak

Singh

Parashar

2020

Environ Sci Pollut Res

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Effects of Thiamin and Methionine Administration in Preventing Cadmium-Induced Biochemical Alterations and Metal Concentration in Male Rats

Cited by 3 publications

References 13 publications

Nutrients intake as determinants of blood lead and cadmium levels in Colombian pregnant women

Nutrients intake as determinants of blood lead and cadmium levels in Colombian pregnant women

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

Metal toxicity and natural antidotes: prevention is better than cure

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