Nutrients intake as determinants of blood lead and cadmium levels in Colombian pregnant women

Suárez‐Ortegón, Milton Fabian; Mosquera, Mildrey; Caicedo, Diana María; Plata, Cecilia Aguilar de; Méndez, Fabián

doi:10.1002/ajhb.22375

Cited by 20 publications

(10 citation statements)

References 55 publications

(53 reference statements)

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“…In 6-year old As-exposed children, one-carbon cycle supplementation was associated with re-methylation of interspersed repeat elements [50] and lower As levels [51]. Although fewer studies have been conducted on Pb or Cd, negative associations with folate or vitamin B12 have been reported [71]. Our data provides evidence for negative associations between folate in combination with Fe, Ca and Se, and Cd or Pb levels.…”

Section: Discussionmentioning

confidence: 64%

Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight

et al. 2017

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BackgroundCadmium (Cd), lead (Pb) and arsenic (As) are common environmental contaminants that have been associated with lower birthweight. Although some essential metals may mitigate exposure, data are inconsistent. This study sought to evaluate the relationship between toxic metals, nutrient combinations and birthweight among 275 mother-child pairs.MethodsNon-essential metals, Cd, Pb, As, and essential metals, iron (Fe), zinc (Zn), selenium (Se), copper (Cu), calcium (Ca), magnesium (Mg), and manganese (Mn) were measured in maternal whole blood obtained during the first trimester using inductively coupled plasma mass spectrometry. Folate concentrations were measured by microbial assay. Birthweight was obtained from medical records. We used quantile regression to evaluate the association between toxic metals and nutrients due to their underlying wedge-shaped relationship. Ordinary linear regression was used to evaluate associations between birth weight and toxic metals.ResultsAfter multivariate adjustment, the negative association between Pb or Cd and a combination of Fe, Se, Ca and folate was robust, persistent and dose-dependent (p < 0.05). However, a combination of Zn, Cu, Mn and Mg was positively associated with Pb and Cd levels. While prenatal blood Cd and Pb were also associated with lower birthweight. Fe, Se, Ca and folate did not modify these associations.ConclusionSmall sample size and cross-sectional design notwithstanding, the robust and persistent negative associations between some, but not all, nutrient combinations with these ubiquitous environmental contaminants suggest that only some recommended nutrient combinations may mitigate toxic metal exposure in chronically exposed populations. Larger longitudinal studies are required to confirm these findings.Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-017-4225-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 64%

Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight

et al. 2017

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“…There are some limitations of using creatinine to adjust for urine dilution [56]. Although U-Cd was assessed in early pregnancy, previous studies have showed that urinary Cd concentrations remain constant over the course of pregnancy [57, 58]. The inverse associations between U-Cd and MAP cannot be extended to the general population due to effect modification of micronutrients and pre-pregnancy BMI.…”

Section: Discussionmentioning

confidence: 99%

Associations of Maternal Urinary Cadmium with Trimester-Specific Blood Pressure in Pregnancy: Role of Dietary Intake of Micronutrients

Osorio-Yáñez

Gelaye

Miller

et al. 2016

Biol Trace Elem Res

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Previous studies revealed associations of urinary Cd (U-Cd), a chronic Cd exposure biomarker, with blood pressure (BP) in non-pregnant adults. However, the evidence regarding trimester-specific blood pressure in pregnancy and U-Cd and effect modification by dietary intake of micronutrients is scarce. We randomly selected 653 women from the Omega Study cohort. U-Cd was quantified by inductively coupled plasma mass spectrometry. Trimester-specific, systolic (SBP) and diastolic blood pressure (DBP) were determined employing standard protocols and mean arterial pressure (MAP) was also calculated. Associations of SBP, DBP, and MAP with U-Cd tertiles (≤0.21; 0.22-0.41; ≥0.42 μg/g Cr) were assessed using multivariable linear regression models. We also explored effect modification by pre-pregnancy BMI (≤25 or >25 kg/m) or low/high micronutrients intake. After adjusting confounders in women with elevated (upper tertile) as compared with those with low (lowest tertile) U-Cd (≥0.42 vs. ≤0.21 μg/g Cr, respectively) had reduced third trimester MAP (-1.8; 95 % confidence interval (CI) = -3.1, -0.5 mmHg) and second trimester MAP (-1.1; 95 % CI = -2.3, -0.03 mmHg). A significant decrease in third-trimester MAP associated with increased U-Cd was observed only among normal/underweight women (BMI ≤ 25 kg/m) and women with high dietary intake of micronutrients (calcium, magnesium, zinc, and selenium). Notably, U-Cd concentrations increased with the increased consumption of zinc and non-heme iron food sources. No significant differences in U-Cd concentrations were found in preeclamptic women compared with non-preeclamptic women. Our study provides evidence that dietary intake of micronutrients should be taken into account when assessing the health effects of Cd in pregnant women.

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“…We additionally performed stratified analyses according to the dietary calcium intake, as calcium was related to both blood Pb level and alcohol drinking [ 22 , 23 ]. Interestingly, in the high calcium-intake group, C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671 polymorphisms were not associated with blood Pb levels.…”

Section: Resultsmentioning

confidence: 99%

Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

et al. 2017

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BackgroundLead (Pb) is a ubiquitous toxic metal present in the environment that poses adverse health effects to humans. Inter-individual variation in blood Pb levels is affected by various factors, including genetic makeup. However, limited data are available on the association between genetic variation and blood Pb levels. The purpose of this study was to identify the genetic markers associated with blood Pb levels in the Korean population.MethodsThe study subjects consisted of 1,483 healthy adults with no history of occupational exposure to Pb. We measured blood Pb levels and calculated probable daily intake of Pb according to dietary data collected using 24-hour recall. We conducted exome-wide association screening using Illumina Human Exome-12v1.2 platform (n = 500) and a replication analysis using VeraCode Goldengate assay (n = 1,483).ResultsAmong the 244,770 single nucleotide polymorphisms (SNPs) tested, 12 SNPs associated with blood Pb level were identified, with suggestive significance level (P < 1 × 10−4). In the Goldengate assay for replication, three SNPs (C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671) were associated with statistically suggestively significant differences in blood Pb levels. When stratified by drinking status, a potential association of C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671 with blood Pb level was observed only in drinkers. A marginally significant gene-environment interaction between ALDH2 rs671 and alcohol consumption was observed in relation to blood Pb levels. The effects of the three suggestively significant SNPs on blood Pb levels was dependent on daily calcium intake amounts.ConclusionsThis exome-wide association study indicated that C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671 polymorphisms are linked to blood Pb levels in the Korean population. Our results suggest that these three SNPs are involved in the determination of Pb levels in Koreans via the regulation of alcohol drinking behavior, and that their negative effects may be compensated by appropriate calcium intake.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0220-x) contains supplementary material, which is available to authorized users.

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Nutrients intake as determinants of blood lead and cadmium levels in Colombian pregnant women

Cited by 20 publications

References 55 publications

Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight

Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight

Associations of Maternal Urinary Cadmium with Trimester-Specific Blood Pressure in Pregnancy: Role of Dietary Intake of Micronutrients

Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

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