The thermal-hydraulic performance of microchannel heat sinks with ribs in the interrupted transverse microchambers is studied using a three-dimensional conjugated heat transfer model and considering entrance effect, viscous heating and temperature-dependent thermophysical properties. Five different configurations of ribs and four lengths along the flow direction for every rib configuration are selected to analyze the effects of rib geometry on the thermal-hydraulic performance. The five rib configurations are rectangular, backward triangular, diamond, forward triangular and ellipsoidal, and the rib geometry parameters include expansion-constriction profile, ratio and length. The effects of rib geometry on thermal-hydraulic performance are firstly examined by the variations of friction factor and Nusselt number with Reynolds number, and corresponding correlations are proposed. Then, the conductive, convective and fluid capacitive thermal resistances are analyzed to obtain some insight into the basic heat transfer mechanism. Next, the entropy generation rates due to heat transfer and fluid friction are investigated for the analysis of the lost available work and irreversibility in the heat transfer process. Finally, the performance evaluation criteria is calculated to comprehensively assess the performance of such interrupted microchannel heat sinks with different rib geometry. For the studied operation parameters and rib geometries, the interrupted microchannel