Effects of the blockade of the system of opioid peptides on changes in emotional/behavioral reactions of rats induced by the action of extrahigh-frequency electromagnetic radiation in the norm and under conditions of hypokinetic stress

Abstract

We studied the effects of pharmacological blockade (by injections of naloxone) of the system of opioid peptides on changes in emotional/behavioral reactions of rats in the open-field test. These changes were caused by the isolated action of low-intensity electromagnetic radiation (EMR) of extrahigh frequency (EHF) and its combination with experimentally induced hypokinetic stress. We conclude that one of the mechanisms of physiological effects of low-intensity EHF EMR is an increase in the functional activity of the system of regulatory opioid peptides; this results in adaptive modifications of the emotional/behavioral reactions under new conditions of the open-field test and provide an anti-stress effect under conditions of hypokinetic stress.

Background activity of neurons of the supraoptic hypothalamic nucleus in rats under conditions of vibrational stimulation and electromagnetic extrahigh-frequency irradiation

“…This fact is indicative of a certain antistressor effect of EHF EMR [6,7,9,11,23]. This conclusion is supported by significant decrease in the mean discharge frequency of stationary spike trains, as compared with that observed in the case of isolated action of vibration.…”

“…As is supposed, effects of the used irradiation are to a considerable extent related to suppression of hyperactivity of the stress-realizing systems [10] and to intensification of activity of the stresslimiting systems of the organism [23,25]. According to the statement that some general decrease in the excitability of cerebral systems and generalization of the inhibitory processes are global effects of EHF EMR [23,26], it seems logical to suppose that the described shifts of the parameters of impulse activity generated by cells of the supraoptic nucleus are initiated by augmentation of the activity of the GABA-ergic cerebral system that mostly mediates inhibitory synaptic transmission. It should, however, be taken into account, that under conditions of intense activation of GABA A receptors, GABA acts in some cases as an excitatory transmitter (due to changes in the gradients of chloride, potassium, and bicarbonate ions) [27].…”

“…The inhibitory/ protective effects of this irradiation are blocked under conditions of injections of naloxone into the experimental animals [23,25,30]. The system of opioid peptides is known to constitute a significant component of the mechanisms providing formation and regulation of the responses of the organism to extraordinary influences.…”