Succinate-dependent Ca2+ accumulation was investigated in rat liver mitochondria and in operation biopsies of patients under states either with prevalence of adrenergic influences (administration of activating doses of adrenaline, acute phase of immobilization stress, initial period after allogenic transplantation, and acute phase of myocardial infarction) or with prevalence of the reciprocal mediator acetylcholine (late period after transplantation, chronic ulcer disease of stomach and duodenum). Adrenaline prevalence leads to increase of succinate-dependent ATP synthesis and Ca2+ accumulation, which is due to known activation of succinate oxidation. However, together with activation, inhibition of these processes was revealed. The inhibition phase prevails under chronic pathology. Therefore, reciprocal regulation of succinate oxidation and succinate-dependent Ca2+ transport in mitochondria occurs in the body in the course of adaptation. The reciprocal regulation of mitochondrial processes is considered as a mechanism of reciprocal regulation of physiological functions.
Acute experiments on white rats anesthetized with Nembutal (40 mg/kg, i.p.) were performed with extracellular recording and analysis of background spike activity from neurons in the supraoptic nucleus of the hypothalamus after exposure to electromagnetic radiation in the millimeter range. The distribution of neurons was determined in terms of the degree of regularity, the nature of the dynamics of neural streams, and the modalities of histograms of interspike intervals; the mean neuron spike frequency was calculated, along with the coefficient of variation of interspike intervals. These studies demonstrated changes in the background spike activity, predominantly affecting the internal structure of the spike streams recorded. The major changes were in the duration of interspike intervals and the degree of regularity of spike activity. Statistically significant changes in the mean spike frequencies of neuron populations in individual frequency ranges were also seen.
Acute experiments on Nembutal-anesthetized (40 mg/kg, i.p.) white rats with extracellular recording and analysis of baseline spine activity of neurons in the fastigial nucleus of the cerebellum were performed in normal conditions and after exposure to vibration for 5, 10, and 15 days. The distribution of neurons in terms of the regularity and dynamics of spike flows and the modality of interspike interval histograms were determined, along with the mean neuron spike frequency and the coefficient of variation of interspike intervals. The results showed that the most significant changes in neuron activity in fastigial nucleus cells were formed during the first ten days of vibration. On day 15, there was a tendency for measures to return to control levels.
In acute experiments on nembutal-anesthetized (40 mg/kg, i.p.) albino rats, we recorded extracellularly and analyzed the background impulse activity (BIA) of neurons of the fastigial nucleus of the cerebellum. Experiments were carried out on intact and labyrinthectomized rats in the norm and after long-lasting (up to 15 days) influence of general vertical vibration (60 Hz, 0.4 mm, 2-h-long everyday sessions). Distributions of the neurons according to the level of regularity of BIA, dynamics of spike trains, pattern of histograms of interspike intervals (ISIs), and different frequency ranges of BIA were plotted; the mean frequency of this activity and the coefficient of variation of ISIs were also calculated. Possible mechanisms of the effects of long-lasting vibration of different durations on the BIA generated by neurons of the fastigial cerebellar nucleus in intact animals and after switching off of labyrinth afferent inputs are discussed.
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