Effects of Telfairia Occidentalis Seeds on the Serum Lipid Profile and Atherogenic Indices of Male Albino Wistar Rats

Onuegbu, Anaelechi J.; Olisekodia, Japhet M.; Tochukwu, Ude; Amah, Ubuo K.; Okwara, John E.; Ifeadike, Chigozie Ozoemena; Ayelagbe, Olubunmi G.

doi:10.3923/pjn.2015.557.562

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…When comparing treated and protected groups with hyperlipidemia, they showed significant decrease in LDL-C, VLDL-C and phospholipids with a significant increase in HDL-C. Such results agree with Shobana and Jayachitra (2015) and Onuegbu et al (2015). LDL-C is likely to decrease following a reduction in cholesterol levels.…”

Section: Discusionsupporting

confidence: 89%

Effect of pumpkin seed oil on lipid metabolism in experimental hyperlipidemic rats

Elsenousy

Farid

Fararh

2019

Benha Veterinary Medical Journal

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The present study was designed to investigate the hypolipidemic effect of pumpkin seed oil in experimental hyperlipidemic rats. Fifty male rats were divided into five equal groups. Group 1: normal rats fed on normal diet. Group 2: (hyperlipidemic group) rats administered standard diet+ 20%coconut oil and 1% cholesterol daily for eight weeks. Group 3: (hyperlipidemic +pumpkin seed oil treated group) rats administered standard diet+ 20%coconut oil and 1% cholesterol daily for four weeks followed by atherogenic diet+ 50 mg/Kg b. wt. pumpkin seed oil daily for other four weeks. Group 4: (hyperlipidemic +pumpkin seed oil protected group) rats administered standard diet+ 50 mg/Kg b. wt. pumpkin seed oil daily for two weeks followed by standard diet+ 20%coconut oil and 1% cholesterol+ 50 mg/Kg b. wt. pumpkin seed oil daily for eight weeks. Group 5 : (pumpkin seed oil group) rats administered standard diet+ 50 mg/Kg b. wt. pumpkin seed oil daily for eight weeks. Blood samples collected for serum separation and used for determination of lipids profile (total cholesterol, triacylglycerol, LDL-C, HDL-C, VLDL-C, total lipids and phospholipids), liver marker enzymes (ALT and AST), albumin, kidney function markers (urea and creatinine) and glucose concentration. The results revealed that in group 2 there were significant increases in serum total cholesterol, triglycerides, LDL-C, VLDL-C, phospholipids, total lipids, ALT, AST, urea, creatinine and glucose while HDL-C and albumin were significantly decreased. Meanwhile, administration of pumpkin seed oil resulted in significant decrease in all elevated mentioned parameters and increase in HDL-C and albumin levels. Therefore, it could be concluded that pumpkin seed oil has hypolipidemic and hypoglycemic effect in rats fed high fat diet.

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Section: Discusionsupporting

confidence: 89%

Effect of pumpkin seed oil on lipid metabolism in experimental hyperlipidemic rats

Elsenousy

Farid

Fararh

2019

Benha Veterinary Medical Journal

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“…Its hepatoprotective effects on the liver have been reported [ 9 ], while Ajani and Akinyemi [ 10 ] highlighted its therapeutic efficacy on induced benign prostatic hyperplasia. Finally [ 11 ], reported that its seeds and leaves supplement had positive effects on biochemical enzymes on lipid profiles in the liver at varying dosages.…”

Section: Introductionmentioning

confidence: 99%

Spermatogenic and spermatotoxic effects of Telfairia occidentalis (Ugu) aqueous leaves extract in adult male Wistar rats (Rattus novergicus)

2018

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Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

et al. 2018

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Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats.Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days.Results: At the end of the intervention, diabetic control rats showed significant (p<0.05) weight reduction, abnormal haematological parameters, high serum lipids (except high density lipoprotein) concentrations, increased creatinine, bilirubin and urea levels with decreased in albumin level when compared with non-diabetic control rats. All these alterations were reverted to normal after administered with different doses of ethanol extract of Artocarpus heterophyllus stem bark most especially at 150 mg/kg body weight which exhibited no significant (p>0.05) different with non-diabetic rats.Conclusion: The results suggest that ethanol extract of Artocarpus heterophyllus stem bark may be useful in ameliorating complications associated with diabetes mellitus patients.

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Effects of Telfairia Occidentalis Seeds on the Serum Lipid Profile and Atherogenic Indices of Male Albino Wistar Rats

Cited by 3 publications

References 24 publications

Effect of pumpkin seed oil on lipid metabolism in experimental hyperlipidemic rats

Effect of pumpkin seed oil on lipid metabolism in experimental hyperlipidemic rats

Spermatogenic and spermatotoxic effects of Telfairia occidentalis (Ugu) aqueous leaves extract in adult male Wistar rats (Rattus novergicus)

Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

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