Effects of tamoxifen citrate on postoperative intra-abdominal adhesion in a rat model

Karaca, Turgut; Gözalan, Ahmet Uğur; Yoldaş, Ömer; Bilgin, Bülent Çağlar; Tezer, Ayla

doi:10.1016/j.ijsu.2012.11.015

Cited by 17 publications

(15 citation statements)

References 25 publications

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“…In a previous study in a rat model, it was reported that the antifibrotic effects of tmx are associated with reduced TGF‐β1 levels, which in turn is related to the reduction in postoperative adhesion in a dose‐ and time‐dependent manner (Karaca et al . ). Therefore, in the present study, we decided to use a higher dose for a longer duration.…”

Section: Discussionmentioning

confidence: 97%

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Effect of tamoxifen on fibrosis, collagen content and transforming growth factor‐β1, ‐β2 and ‐β3 expression in common bile duct anastomosis of pigs

Siqueira

Oliveira

Carvalho

et al. 2017

Int J Experimental Path

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End-to-end anastomosis in the treatment for bile duct injury during laparoscopic cholecystectomy has been associated with stricture formation. The aim of this study was to experimentally investigate the effect of oral tamoxifen (tmx) treatment on fibrosis, collagen content and transforming growth factor-β1, -β2 and -β3 expression in common bile duct anastomosis of pigs. Twenty-six pigs were divided into three groups [sham (n = 8), control (n = 9) and tmx (n = 9)]. The common bile ducts were transected and anastomosed in the control and tmx groups. Tmx (40 mg/day) was administered orally to the tmx group, and the animals were euthanized after 60 days. Fibrosis was analysed by Masson's trichrome staining. Picrosirius red was used to quantify the total collagen content and collagen type I/III ratio. mRNA expression of transforming growth factor (TGF)-β1, -β2 and -β3 was quantified using real-time polymerase chain reaction (qRT-PCR). The control and study groups exhibited higher fibrosis than the sham group, and the study group showed lower fibrosis than the control group (P = 0.011). The control and tmx groups had higher total collagen content than the sham group (P = 0.003). The collagen type I/III ratio was higher in the control group than in the sham and tmx groups (P = 0.015). There were no significant differences in the mRNA expression of TGF-β1, -β2 and -β3 among the groups (P > 0.05). Tmx decreased fibrosis and prevented the change in collagen type I/III ratio caused by the procedure.

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Section: Discussionmentioning

confidence: 97%

“…; Karaca et al . ). High expression of TGF‐β1 is related to chronic inflammation, extracellular matrix over deposition and scar contracture of the bile duct caused by bile (Geng et al .…”

mentioning

confidence: 97%

Effect of tamoxifen on fibrosis, collagen content and transforming growth factor‐β1, ‐β2 and ‐β3 expression in common bile duct anastomosis of pigs

Siqueira

Oliveira

Carvalho

et al. 2017

Int J Experimental Path

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“…Tamoxifen, a synthetic nonsteroidal anti-estrogen agent, with anti-fibrotic properties, has also been used successfully in rats. (230) The efficacy of sex hormones appears to be unpredictable and human application has been unsuccessful. (231,232) As nitric oxide (NO) participates in the inflammatory phase of adhesion formation by generating reactive oxygen species, increasing vasodilatation, and its inhibition by using methylene blue or aminoguanidine has been shown effective in experimental models.…”

Section: Inflammatory Phasementioning

confidence: 99%

Intra-abdominal adhesions: Anatomy, physiology, pathophysiology, and treatment

Beyene¹,

Kavalukas²,

Barbul³

2015

Current Problems in Surgery

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“…Other formulations containing therapeutic agents have been presented as potent candidates to prevent mesh visceral adhesion in rodent models (i.e., taxomifen and sirolimus) . However, before drawing real beneficial effect, those drugs have to be validated pre‐clinically on larger animal models, taking into account their serious side‐effects.…”

Section: Anti‐adhesive Meshmentioning

confidence: 99%

Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio‐Functionality to Meshes

Guillaume

Teuschl

Gruber-Blum

et al. 2015

Adv Healthcare Materials

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Abdominal wall hernia is a recurrent issue world-wide and requires the implantation of over 1 million meshes per year. Because permanent meshes such as polypropylene and polyester are not free of complications after implantation, many mesh modifications and new functionalities have been investigated over the last decade. Indeed, mesh optimization is the focus of intense development and the biomaterials utilized are now envisioned as being bioactive substrates that trigger various physiological processes in order to prevent complications and to promote tissue integration. In this context, it is of paramount interest to review the most relevant bio-functionalities being brought to new meshes and to open new avenues for the innovative development of the next generation of meshes with enhanced properties for functional abdominal wall hernia repair.

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Effects of tamoxifen citrate on postoperative intra-abdominal adhesion in a rat model

Abstract: In conclusion tamoxifen citrate seems to be useful for preventing postoperative intra-abdominal adhesions. Its effects are in a dose and time dependent manner. Further studies must be carried out to use tamoxifen for preventing intra-abdominal postoperative adhesions in clinical practice.

Cited by 17 publications

References 25 publications

Effect of tamoxifen on fibrosis, collagen content and transforming growth factor‐β1, ‐β2 and ‐β3 expression in common bile duct anastomosis of pigs

Effect of tamoxifen on fibrosis, collagen content and transforming growth factor‐β1, ‐β2 and ‐β3 expression in common bile duct anastomosis of pigs

Intra-abdominal adhesions: Anatomy, physiology, pathophysiology, and treatment

Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio‐Functionality to Meshes

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