Effects of Supplemental Threonine on Antioxidant Enzyme Activities and Haemato-biochemical Profile of Commercial Broilers in Sub-Tropics

Effects of Dietary Threonine Levels on Intestinal Immunity and Antioxidant Capacity Based on Cecal Metabolites and Transcription Sequencing of Broiler

“…In our study, the CAT expression was upregulated; Debnath et al [10] came to the same conclusion—of great significance to the antioxidant ability of broilers—finding it to be higher in the THR125 group when compared with THR100. In broilers, Thr plays a vital role in the synergistic effects of the scavenging of reactive oxygen free radicals and the regulation of peroxidase on membrane lipid peroxidation.…”

“…There were 10 different genes, which included 9 with an upregulated expression: ABCA1, ABCA2, ABCB1, ABCB4, ABCC2, ABCC6, ABCD2, ABCG5, ABCG8, and with a downregulated expression, ABCB3 [46]. The results of this change demonstrate the correctness of our previous experiment—compared with the 100% NRC group, the concentration of serum total protein and globulin in the 125% NRC group was significantly higher than that of Debnath et al [10], indicating that the total protein concentration and serum globulin level increased linearly. The conversion efficiency of some proteins affects the metabolic process.…”

“…In broilers, Thr plays a vital role in the synergistic effects of the scavenging of reactive oxygen free radicals and the regulation of peroxidase on membrane lipid peroxidation. Liu et al [7] and Debnath et al [10] found that when the addition of THR was higher than the recommended amount, the activity of serum GSH-PX and total superoxide dismutasewas higher. Our results indicated that excessive Thr could significantly increase the antioxidant enzyme activity of broilers, which is consistent with Habte et al [12] and Azzam et al [9].…”

“…A number of studies have shown that adding a higher level of Thr in broiler diet than is recommended by the NRC improved antioxidant ability and immune function [5,6,7,8,9]. Debnath et al [10] found serum glutathione peroxidase (GSH-PX) and catalase concentration and superoxide dismutase (SOD) level increased linearly with the increasing of Thr level, which was similar to Azzam et al [9] and Liu et al [7]. Thr may be a nutritional immunomodulator affecting intestinal barrier function, which can improve immunity and intestinal health of broilers, especially 125% NRC Thr level [11].…”