Effects of substances on plants' active compounds on changes in the hormone levels of the pituitary–Thyroid axis in hyperthyroidism and hypothyroidism

Aleebrahim-Dehkordy, Elahe; Ansaripour, Sadra; Rafieian-Kopaei, Mahmoud; Saberianpour, Shirin

doi:10.4103/phrev.phrev_48_17

Cited by 4 publications

(1 citation statement)

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“…Nowadays, to discover new therapeutic methods that are more economical with fewer side effects, the study of medicinal plants and their properties is particularly important so that over 30% of medicinal plants are currently being used in hospitals and clinics (8,9). Herbal drugs are usually a complex of hundreds of different chemical compounds, but only a few of them are responsible for the beneficial or adverse effects of these drugs (10).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effects of Hydroalcoholic and Aqueous Extracts of Two Medicinal Plants in Comparison with Popular Antibiotics: An In Vitro Study

Ansaripour

Safaei

Bagheri

2020

Zahedan J Res Med Sci

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Background: Acinetobacter baumannii is considered a dangerous and drug-resistant hospital-acquired infection. Nowadays, there has been an increasing interest in the use of herbal drugs. Objectives: This in vitro study was conducted to determine the antimicrobial effects of Rumex acetosella L. and Cucurbita maxima L. on Acinetobacter baumannii in comparison with popular antibiotics. Methods: In this experimental study, after extraction, the antibacterial effects of extracts were determined based on MIC and MBC using broth microdilution. The effects of different concentrations of the extracts on A. baumannii growth were also investigated by the disk diffusion method. The results were compared with choice antibiotics. Results: The results of the study indicated that in broth microdilution, the MIC and MBC of the hydroalcoholic extract of C. maxima and the aqueous extract of R. acetosella were equal (64 and 128 µg/mL, respectively). The MIC and MBC of the hydroalcoholic extract of R. acetosella and the aqueous extract of C. maxima were 128 and 256 µg/mL, respectively, which indicated the weaker effects of these extracts. In the disk diffusion method, the greatest mean diameter of inhibition zone was obtained for R. acetosella extracts (24.83 ± 0.29 and 21.83 ± 0.29 mm for hydroalcoholic and aqueous extracts, respectively). Also, the lowest mean diameter was obtained for C. maxima extracts (10.33 ± 0.58 and 8 mm for hydroalcoholic and aqueous extracts, respectively). Conclusions: This study showed the potent antibacterial effects of R. acetosella and C. maxima. They were even more potent than commonly used antibiotics. Therefore, the plants can be used as antimicrobial agents, as well as pharmaceutical supplements and alternative therapies.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Effects of Hydroalcoholic and Aqueous Extracts of Two Medicinal Plants in Comparison with Popular Antibiotics: An In Vitro Study

Ansaripour

Safaei

Bagheri

2020

Zahedan J Res Med Sci

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IMPACT OF Pleurotus tuber-regium (Rumph. ex Fr.) EXTRACT-LOADED NANOPARTICLES ON THYROID PROFILE OF RATS

Dandapat¹

2021

Biotechnol. acta

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Aim. The aim of this study was to investigate the impact of Pleurotus tuber-regium extract loaded silver nanoparticles (SNPs) on thyroid profile of rats. Methods. Acute toxicity test was performed following up and down procedure and the analysis of thyroid profile was performed following chemiluminescence assay method. Results. Acute toxicity test showed no mortality and no behavioral changes in rats treated with 2000 mg kg-1 of SNPs. High dose (400 mg kg-1) of SNPs showed high hyper thyroid activity by increasing T3 = 38.20±4.06 ng dL-1; T4 = 4.40±0.32µg dL-1; and by decreasing TSH = 0.73±0.06µIU mL-1 compared to control group (T3 = 30.20±1.02 ng dL-1; T4 = 2.94±0.08µg dL-1; TSH = 0.87±0.01µIU mL-1) and animal group treated with 200 mg kg-1 dose of SNPs (T3 = 35.69±1.13 ng dL-1; T4 = 3.82±0.24µg dL-1; TSH = 0.80±0.02µIU mL-1). Conclusions. Pleurous tuber-regium extract loaded silver nanoparticles are non toxic and can be used in drug delivery as well as in the formulation of drugs used in hypothyroidism.

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Role of Herbal Bioactive Compounds as a Potential Bioavailability Enhancer for Active Pharmaceutical Ingredients

Sawicka

Ziarati

Messaoudi

et al. 2022

Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery

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Bioactive compounds of plant origin are used all over the world because of their positive impact on human and animal health and because of their beneficial, specific properties. The most popular bioactive compounds beneficial to health have been identified and defined earlier. Others are yet to be discovered. In particular, the most common biological activities of these compounds were indicated, such as antiallergic, antidepressant, antidiabetic, anti-inflammatory, antimicrobial, antioxidant, antitumor, antiviral, antithyroid, anxiolytic, to cardioprotective, hepatoprotective, and flatulence-inhibiting effects. The beneficial properties of bioactive compounds may be associated with substances like alcohols, terpenoids, phenolic antioxidants, and rosmarinic acid, which are present in several medicinal plants. The updated review considers the physiological, botanical, phytochemical, and medical aspects of herbal bioactive compounds as well as their therapeutic properties, with a focus on their health benefits and the potential use of nutraceuticals.

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Effects of substances on plants' active compounds on changes in the hormone levels of the pituitary–Thyroid axis in hyperthyroidism and hypothyroidism

Cited by 4 publications

References 4 publications

Antibacterial Effects of Hydroalcoholic and Aqueous Extracts of Two Medicinal Plants in Comparison with Popular Antibiotics: An In Vitro Study

Antibacterial Effects of Hydroalcoholic and Aqueous Extracts of Two Medicinal Plants in Comparison with Popular Antibiotics: An In Vitro Study

IMPACT OF Pleurotus tuber-regium (Rumph. ex Fr.) EXTRACT-LOADED NANOPARTICLES ON THYROID PROFILE OF RATS

Role of Herbal Bioactive Compounds as a Potential Bioavailability Enhancer for Active Pharmaceutical Ingredients

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