Effects of subfertility cause, smoking and body weight on the success rate of IVF

Lintsen, A.M.E.; Jong, P.C.M. Pasker-de; Boer, E. J. de; Burger, Curt W.; Jansen, C.A.M.; Braat, D.D.M.; Leeuwen, F.E. van

doi:10.1093/humrep/deh898

Cited by 220 publications

(130 citation statements)

References 25 publications

(30 reference statements)

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“…All the subjects had to fulfil the following inclusion criteria: (1) regular menstrual cycles (28-35 days), (2) first ovarian stimulation treatment, (3) both ovaries visualised on transvaginal ultrasound, (4) no use of hormone therapy in the 6 months before entering the study, (5) no history of premature ovarian failure and/or autoimmune diseases, (6) no previous ovarian surgery, (7) no exposure to cytotoxic drugs or pelvic radiation therapy, and (8) BMI>19< 30 kg/m 2 . Written informed consent was obtained.…”

Section: Methodsmentioning

confidence: 99%

“…There is also evidence that smoking negatively impacts on all areas of fertility from follicle development to fertilization and embryo cleavage. When in vitro fertilization (IVF) is used, fewer follicles are stimulated, fewer oocytes are retrieved, implantation rates are lower, more cycles are cancelled and live birth rates are significantly lower in smokers when compared to non-smokers [5][6][7][8]. Interestingly, passive smoking is found to be just as detrimental to fertility as active smoking, halving the pregnancy rate [9].…”

Section: Introductionmentioning

confidence: 99%

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Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Robinson

Pemberton

Laing

et al. 2008

J Assist Reprod Genet

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Purpose To assess the relationship between low-grade inflammation, measured as basal high sensitivity (hs)-CRP, and IVF outcome. Methods We recruited a total of 220 women undergoing infertility work up prior to IVF. Patients were selected for a BMI<30 kg/m 2 with an upper age limit of 40 years. Serum hs-CRP levels were measured on day 3 of a spontaneous menstrual cycle preceding ovarian stimulation. A sensitive two-site ELISA was used for analysis. Dose of gonadotrophins required, follicles days 8 and 10, number of oocytes collected, number of oocytes fertilised and pregnancy outcome were recorded. Results Median hs-CRP was 1.08 mg/L (0.43-3.00 mg/L). The hs-CRP was significantly related to BMI (r=0.386, P<.001) but not to age and smoking habit. There were no significant relationships between basal hs-CRP and any of the measured IVF outcomes. Conclusions These findings demonstrate that serum hs-CRP concentration is not a predictive marker of cycle or pregnancy outcome in women undergoing IVF treatment.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Robinson

Pemberton

Laing

et al. 2008

J Assist Reprod Genet

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show abstract

“…However, the evidence is conflicting regarding the effect that obesity has on live birth rates in assisted reproductive outcomes. Studies have shown lower clinical pregnancy rates, higher miscarriage rates, and decreased live birth rates in women with an elevated body mass index [9,[12][13][14]. Other studies, however, have shown no difference in live birth rates when comparing IVF outcomes between normal-weight and obese patients [7,8,15].…”

Section: Introductionmentioning

confidence: 99%

Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Comstock

Kim

Behr

et al. 2015

J Assist Reprod Genet

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Purpose The aim of this study is to investigate the effect of female BMI and metabolic dysfunction on blastocyst formation rate. Methods This was a retrospective cohort study that was performed in an academic center for reproductive medicine. Patients who were normal weight, overweight with metabolic dysfunction, or obese who had ≥6 oocytes retrieved in a fresh IVF cycle were included in the study. The blastocyst formation rate was calculated from the number of ≥5 cell embryos on day 3 observed in culture until day 5 or day 6. Only good quality blastocysts were included in the calculation as defined by a morphologic grade of 3BB or better. Results The blastocyst formation rate was significantly better in the normal-weight controls versus overweight/obese patients (57.2 versus 43.6 %, p<0.007). There was no difference in blastocyst formation between the patients with a BMI 25-29.9 kg/m 2 with metabolic dysfunction and those with a BMI ≥30 kg/m 2 . Conclusion The maternal metabolic environment has a significant impact on embryo quality as measured by blastocyst formation. A decreased blastocyst formation rate is likely a significant contributor to poorer reproductive outcomes in overweight and obese women with infertility.

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“…For example, a number of reports have highlighted the influence of ethnicity on outcome of IVF treatment, [15][16][17][18][19] ), although the direction of its impact (positive or negative) is unclear, mainly due to the small number of patients from [20][21][22][23] Likewise, the presence of uterine fibroids has been shown to reduce the implantation and pregnancy potential after IVF 24,25 and is more common in certain racial groups. The primary cause of infertility, a factor reported to have an impact on IVF outcome 11,26,27 was also different in the two studied groups.…”

Section: Discussionmentioning

confidence: 99%

Short communication: Validity of the in vitro fertilisation league tables: influence of patients’ characteristics

Johnson

El‐Toukhy

Sunkara

et al. 2007

BJOG

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We tested the hypothesis that restricting comparison of the live birth rate following in vitro fertilisation (IVF) treatment in those couples having their first IVF cycle in whom the female is under 35 years of age and has a normal follicle-stimulating hormone level would improve the validity of comparing IVF clinics' success rates. We analysed all cycles performed over a 2-year period in patients who fulfilled these criteria and divided the study population according to the referring primary care trusts: group A (n = 90) were referred from Lambeth, Southwark and Lewisham and group B (n = 134) were referred from Brent and Harrow. There was no significant difference between the two groups with regard to their IVF cycle characteristics. The two groups differed in their ethnicity, cause of infertility, prevalence of uterine fibroids and smoking and alcohol consumption habits. Group A had a significantly lower live birth rate (OR = 0.45, 95% CI 0.21-0.95, P = 0.02) compared with group B. This study confirms the impact of the non-IVF-related patient characteristics on treatment outcome and the poor validity of comparing IVF clinics' success rates based on the sparse data published by national IVF registries.

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Effects of subfertility cause, smoking and body weight on the success rate of IVF

Cited by 220 publications

References 25 publications

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Short communication: Validity of the in vitro fertilisation league tables: influence of patients’ characteristics

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