Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Robinson, Sarah; Pemberton, P.; Laing, Ian; Nardo, Luciano G.

doi:10.1007/s10815-008-9253-y

Cited by 21 publications

(22 citation statements)

References 27 publications

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“…In contrast, other two papers found no relationship between CRP levels and IVF outcome (Almagor et al 2004;Orvieto et al 2004). Th e articles about hs CRP levels in IVF cycles showed no relationship (Robinson et al 2008;Seckin et al 2012). We found no diff erence in terms of hs CRP levels and there was no change during early post-IUI period.…”

Section: Discussioncontrasting

confidence: 62%

Evaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination

Taşdemir

Şahin

Çelik

et al. 2014

Journal of Obstetrics and Gynaecology

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The implantation of embryo is one of the crucial steps of a successful pregnancy. The foetus should be protected from maternal immune system, for the appropriate implantation and modification in maternal immunity is crucial. We investigated high-sensitivity C-reactive protein (hs CRP), which is an indicator of low-grade inflammation and Cp10 that has immunosuppressant and growth-promoting capabilities at embryo levels in ovulation induction and intra-uterine insemination (IUI)applied in infertile women. The ovulation induction was maintained by clomiphene citrate or gonadotropins for 42 infertile patients. After successful ovulation induction, IUI was carried out. The blood samples were taken 2 and 8 days after IUI to evaluate Cp10 and hs CRP levels. The pregnant and non-pregnant groups' results were analyzed. The Cp10 levels 8 days after IUI were higher in pregnant group, whereas there was no difference for the 2 days after levels between pregnant and non-pregnant group. The hs CRP levels were similar for both 2nd and 8th days when we compared pregnant and non-pregnant groups. The Cp10 levels increased from day 2 to day 8 in pregnant group. In contrast, the Cp10 levels decreased in non-pregnant group. The change in hs CRP levels from day 2 to day 8 was not significant in pregnant and non-pregnant groups. The Cp10 levels were higher in early phases of fertilisation and elevated through the preceding days of conception in pregnant patients, while it decreased in non-pregnant patients with failed cycles.

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Section: Discussioncontrasting

confidence: 62%

Evaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination

Taşdemir

Şahin

Çelik

et al. 2014

Journal of Obstetrics and Gynaecology

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“…There are a lot of studies in the literature researching a relationship between PCOS and inflammatory markers. While some investigators demonstrated significant elevations in NC, WBC count, or hs-CRP [11,29], others could not find increased inflammatory markers in PCOS patients undergoing IVF [30][31][32]. In our study, we demonstrated a significant difference between PCOS and control group regarding NC, neutrophil/leukocyte ratio, and also hs-CRP levels.…”

Section: Discussioncontrasting

confidence: 54%

The effect of serum and follicular fluid amyloid-associated protein levels on in vitro fertilization outcome in patients with polycystic ovary syndrome

Tımur

Yimaz

Kahyaoğlu

et al. 2015

J Assist Reprod Genet

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Purpose In this study, we aimed to investigate serum and follicular fluid amyloid A protein levels in non-obese nonhyperandrogenic patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) and IVF outcome. Methods A total of 81 patients undergoing IVF treatment, 41 patients diagnosed as PCOS according to the Rotterdam criteria (group I) and 40 patients with the etiology of male factor infertility (group II), were included in the study. On the day of oocyte pickup, serum and follicular fluid samples were collected from all patients. Results Serum E2 level on the day of hCG (2849.93±541.54 vs. 2494.28±712.98) and total number of retrieved oocytes (13.73±3.57 vs. 10.53±4.07) were significantly higher in group I when compared to group II (p<0.05). However, number of mature oocytes, fertilization rate, and clinical pregnancy rate did not differ (p>0.05). No significant difference was found between two groups regarding the serum and follicular fluid amyloid A protein levels on the day of oocyte retrieval (p>0.05).

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“…Sarah Robinson et al in a preliminary study on correlation of baseline hs-CRP and in vitro fertilization (IVF) outcome had reported that, baseline hs-CRP is of no use as predictive marker of IVF outcome in routine clinical practice. Their study was conducted in non PCOS women 17.…”

mentioning

confidence: 99%

High sensitivity C - reactive protein (hs-CRP) and clinical characteristics, endocrine, metabolic profile in Indian women with PCOS: a correlation

Ramanand

Raparti

et al. 2014

Int J Reprod Contracept Obstet Gynecol

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Background: Role of hs-CRP was studied in PCOS women. Methods: Correlation between serum hs-CRP and endocrine, metabolic profile was studied in 30 healthy women and 88 PCOS women. In PCOS women correlation between hs-CRP and clinical characteristics viz obesity, infertility, acne, hirsutism, acanthosis nigricans (AN) was also studied. Serum levels of hs-CRP, Luteinizing hormone (LH), Follicle stimulating hormone (FSH), LH:FSH ratio, Testosterone (Testo), fasting insulin, fasting blood glucose (FBG), total cholesterol (TC), triglyceride (Tg), low density lipoprotein (LDL), high density lipoprotein (HDL) and Homeostasis Model Assessment (HOMA) were estimated. Results: Mean serum hs-CRP in PCOS women was higher than that in control women (6.9 ± SE 0.84 v/s 2.0 ± SE 0.19mg/L, P=0.005). In PCOS group overweight/obese had higher hs-CRP as compared to normal weight women (P=0.0051). In control group hs-CRP was positively correlated with age (r=0.385 p=0.035) and LDL (r=0.38 P=0.036). PCOS women showed positive correlation between hs-CRP and cholesterol, LDL, fasting insulin, HOMA. PCOS women showed a significant negative correlation between hs-CRP and LH. AN positive PCOS women showed higher serum hs-CRP levels as compared to AN negative PCOS women (11 ± SE 0.7 v/s 5.5 ± SE 2.3, P=0.0439). Conclusions: Serum hs-CRP is raised in Indian PCOS women reflecting association of low grade chronic inflammation. A positive correlation is present between hs-CRP and AN, insulin in PCOS women and obesity may aggravate this association. A positive correlation between hs-CRP and TC, LDL in the background of normal lipid profile is suggestive of precedence of chronic inflammation over dyslipidemia in PCOS.

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Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Cited by 21 publications

References 27 publications

Evaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination

Evaluation of human chaperonin 10 and high-sensitivity C-reactive protein levels of infertile women who underwent ovulation induction and intra-uterine insemination

The effect of serum and follicular fluid amyloid-associated protein levels on in vitro fertilization outcome in patients with polycystic ovary syndrome

High sensitivity C - reactive protein (hs-CRP) and clinical characteristics, endocrine, metabolic profile in Indian women with PCOS: a correlation

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