Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Comstock, Ioanna A.; Kim, Sun H.; Behr, Barry; Lathi, Ruth B.

doi:10.1007/s10815-015-0515-1

Cited by 59 publications

(48 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A significantly lower number of mature oocytes, as well as oocytes that were reduced in diameter, were observed in ovarian aspirations in IVF cycles among obese women compared with women of a normal weight . Embryos formed from ova of overweight and obese women also exhibited a lower potential for development after IVF, as well as a lower rate of blastocyst formation …”

Section: Discussionmentioning

confidence: 95%

Obesity and recurrent miscarriage: A systematic review and meta‐analysis

Cavalcante

Sarno

Peixoto

et al. 2018

J of Obstet and Gynaecol

107

View full text Add to dashboard Cite

The aim of this study is to perform a systematic review and meta-analysis on the relationship between excess weight and risk of recurrent pregnancy loss (RPL) and to highlight the common immunological mechanisms of these two conditions. The PubMed and MEDLINE databases were searched for publications in English available as of November 2017. The search terms used were 'recurrent pregnancy loss', 'body mass index' (BMI), 'overweight' and 'obesity'. For calculation of the odds ratio (OR) and 95% confidence intervals (CI) for miscarriage in different BMI groups, RevMan software was used (Review Manager, Version 5.3.5 for Windows; The Cochrane Collaboration). In total, 100 publications including the search terms were identified. Six studies were included for qualitative analysis, and two studies were included for quantitative analysis (meta-analysis). The association between excess weight and RPL was significant (OR, 1.34; 95% CI, 1.05-1.70; P = 0.02). The isolated analyses of the groups of obese and overweight women revealed an association only between obesity and RPL (OR, 1.75; 95% CI, 1.24-2.47; P = 0.001). The data available in the current literature revealed that obese women with a history of RPL have a high risk of future pregnancy losses, a risk which was not found among overweight women.

show abstract

Section: Discussionmentioning

confidence: 95%

Obesity and recurrent miscarriage: A systematic review and meta‐analysis

Cavalcante

Sarno

Peixoto

et al. 2018

J of Obstet and Gynaecol

107

View full text Add to dashboard Cite

show abstract

“…Data from the literature are not consensual regarding the effect of obesity and its severity on live birth rate. Indeed, some studies did not find any deleterious effect of BMI, with no significant difference in the live birth rate between normal-weight and overweight women [16,17], but also between normal-weight and obese women [7,18] and between BMI categories [19]. Likewise, Coyne et al showed that gestational carriers' BMI does not impair reproductive outcomes including live birth rate [20].…”

Section: Discussionmentioning

confidence: 99%

Impact of Women Obesity and Obesity Severity on Live Birth Rate after In Vitro Fertilization

Brunet

Aouinti

Huguet³

et al. 2020

JCM

View full text Add to dashboard Cite

Access to in vitro fertilization (IVF) for obese women varies across centers, and the impact of obesity on IVF outcomes is widely discussed. We assessed the impact of obesity and its severity on live birth rate (LBR) after IVF. We included women treated for IVF in our center. Data were prospectively collected in the BabySentryTM software. LBR per cycle and cumulative LBR including all attempts of the couple were calculated, considering transfer of both fresh and frozen embryos. Of 1588 included women (2379 controlled ovarian stimulations), 70.2%, 19.5%, 7.9%, and 2.4% were normal-weight, overweight, class I obesity, and class II/III obesity, respectively. For each cycle, LBR did not differ according to BMI category. Adjusted odds ratios (95% confidence intervals) for obtaining a live birth at the first cycle were 1.11 (0.78–1.58) for overweight, 1.17 (0.70–1.95) for class I obese, and 1.05 (0.48–2.31) for class II/III obese women, as compared with normal-weight women. Similarly, no significant associations were found at cycles 2, 3, and 4. Cumulative LBR increased with the number of cycles, independently of the BMI class (p log-rank = 0.91). After adjustment, obesity status did not impact significantly the miscarriage rate, regardless of the cycle. In conclusion, neither women obesity nor its severity impacted the cumulative LBR after IVF.

show abstract

“…A s the obesity epidemic continues to plague the United States, numerous reports have been published and recommendations made regarding the negative impact of obesity on fertility (1), assisted reproductive technology (ART) effectiveness (2)(3)(4)(5)(6)(7)(8)(9), and pregnancy and obstetric outcomes (5,10). By contrast, limited and conflicting data exist on the impact of being underweight (body mass index [BMI] <18.5 kg/m 2 ), admittedly a less common problem, on fertility and the effectiveness of ART.…”

mentioning

confidence: 99%