Effects of Stress in Early Life on Immune Functions in Rats With Asthma and the Effects of Music Therapy

Lu, Yanxia; Li, Meng; Shi, Shou‐Sen; Jiang, Hong; Yang, Liu; Liu, Xin; Zhang, Qian; Pan, Fang

doi:10.3109/02770901003801964

Cited by 35 publications

(16 citation statements)

References 36 publications

(46 reference statements)

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“…Furthermore, specific type of auditory enrichment used here also affected the immune genes expression in zebrafish vs. unexposed controls ( Fig. 3A ), similar to music effects reported earlier in rodents ( Lu et al, 2010 ; Uchiyama et al, 2012 ). Here, fish exposed to auditory enrichment showed lower expression of some pro-inflammatory genes (IL-1β and IFN-γ), but without affecting anti-inflammatory genes IL-10 and IL-4 ( Fig.…”

Section: Discussionsupporting

confidence: 87%

The effects of auditory enrichment on zebrafish behavior and physiology

Barcellos

Koakoski

Chaulet

et al. 2018

PeerJ

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Environmental enrichment is widely used to improve welfare and behavioral performance of animal species. It ensures housing of laboratory animals in environments with space and complexity that enable the expression of their normal behavioral repertoire. Auditory enrichment by exposure to classical music decreases abnormal behaviors and endocrine stress responses in humans, non-humans primates, and rodents. However, little is known about the role of auditory enrichment in laboratory zebrafish. Given the growing importance of zebrafish for neuroscience research, such studies become critical. To examine whether auditory enrichment by classical music can affect fish behavior and physiology, we exposed adult zebrafish to 2 h of Vivaldi’s music (65–75 dB) twice daily, for 15 days. Overall, zebrafish exposed to such auditory stimuli were less anxious in the novel tank test and less active, calmer in the light-dark test, also affecting zebrafish physiological (immune) biomarkers, decreasing peripheral levels of pro-inflammatory cytokines and increasing the activity of some CNS genes, without overt effects on whole-body cortisol levels. In summary, we report that twice-daily exposure to continuous musical sounds may provide benefits over the ongoing 50–55 dB background noise of equipment in the laboratory setting. Overall, our results support utilizing auditory enrichment in laboratory zebrafish to reduce stress and improve welfare in this experimental aquatic organism.

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Section: Discussionsupporting

confidence: 87%

The effects of auditory enrichment on zebrafish behavior and physiology

Barcellos

Koakoski

Chaulet

et al. 2018

PeerJ

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“…Cross-sectional measurements of HPA and immune function in adulthood may thus vary greatly as a function of relative age of an organism when stressed and/or the chronicity of exposure to a remote stressful environment. The relevance of timing and chronicity effects was illustrated by recent preclinical data demonstrating stress exposure in young rats resulted in the opposite direction changes in both central IL1-β and peripheral corticosterone concentrations than were observed when stress exposure was introduced in adulthood (Lu et al , 2010). …”

Section: Discussionmentioning

confidence: 99%

Association between Plasma IL-6 Response to Acute Stress and Early-Life Adversity in Healthy Adults

Carpenter

Gawuga

Tyrka

et al. 2010

Neuropsychopharmacol

391

289

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Increased production of peripheral cytokines and other pro-inflammatory markers has been linked to psychiatric disorders such as major depressive disorder and posttraumatic stress disorder (PTSD). Recent research has pointed to early life stress, particularly childhood maltreatment, as an independent and preventable risk factor for systemic inflammation in adulthood. Some data suggest that adults with a history of childhood maltreatment exhibit a heightened inflammatory response to acute stress challenge. To further elucidate the relationship between childhood maltreatment and pro-inflammatory cytokine production, we examined plasma IL-6 response to the Trier Social Stress Test (TSST) in 69 healthy adult subjects without depression or PTSD. Serial plasma IL-6 concentrations were measured during a standardized psychosocial stressor in n=19 subjects with moderate-severe childhood maltreatment (MAL) and n=50 controls without maltreatment (CTL), as indicated by self-ratings on the Childhood Trauma Questionnaire (CTQ). CTQ total scores were positively correlated with change in overall change in IL-6 response, as well as the maximum IL-6 concentration during the TSST. Greater acute IL-6 release and higher IL-6 concentrations over time were observed for the MAL group relative to the CTL group. Inflammation may be an important developmental mediator linking adverse experiences in early life to poor adult physical and mental health. The results of this preliminary study warrant further investigation in a larger sample.

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“…This mediator is low-level maternal corticosterone [95•]. In adult mice and rats, OVA sensitization and challenge increases stress [96–101] and increases endogenous serum corticosterone [102, 103]. Moreover, it is reported that symptoms of stress/anxiety are commonly associated with allergy/asthma in adult mice and in humans [104–108].…”

Section: Transplacental Mediators and Development Of Allergic Diseasementioning

confidence: 99%

Maternal Influences over Offspring Allergic Responses

Cook‐Mills

2015

Curr Allergy Asthma Rep

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Asthma occurs as a result of complex interactions of environmental and genetic factors. Clinical studies and animal models of asthma indicate offspring of allergic mothers have increased risk of development of allergies. Environmental factors including stress-induced corticosterone and vitamin E isoforms during pregnancy regulate the risk for offspring development of allergy. In this review, we discuss mechanisms for the development of allergic disease early in life, environmental factors that may impact the development of risk for allergic disease early in life, and how the variation in global prevalence of asthma may be explained, at least in part, by some environmental components.

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Effects of Stress in Early Life on Immune Functions in Rats With Asthma and the Effects of Music Therapy

Abstract: Stress in childhood and adulthood resulted in different HPA axis responsiveness in the exacerbation of markers of asthma. These data provide the first evidence of the long-term normalizing effects of music on asthmatic rats.

Cited by 35 publications

References 36 publications

The effects of auditory enrichment on zebrafish behavior and physiology

The effects of auditory enrichment on zebrafish behavior and physiology

Association between Plasma IL-6 Response to Acute Stress and Early-Life Adversity in Healthy Adults

Maternal Influences over Offspring Allergic Responses

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