Maternal Influences over Offspring Allergic Responses

Cook‐Mills, Joan M.

doi:10.1007/s11882-014-0501-1

Cited by 38 publications

(34 citation statements)

References 112 publications

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“…Other epigenetic modifications, such as histone modification, noncoding RNAs, chromatin remodeling, may be responsible for the changes of Treg cells too. Previous researches indicated that classic genetic inheritance4344 and perinatal transfer of maternal mediators (such as allergens, antibodies or cytokines) via placenta or breast milk454647 might also be responsible for maternal effect.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Immune State Is Influenced by Maternal Allergic Rhinitis and Associated With Regulatory T cells

Tan

Tao

et al. 2017

Allergy Asthma Immunol Res

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PurposeMaternal influences contribute to the origin of allergic diseases, but the mechanisms are not clear. The current literature prompted the role of epigenetics in the development of allergic diseases. We sought to investigate the roles of regulatory T (Treg) cells and Forkhead box p3 (Foxp3) DNA methylation in the process of maternal transmission of allergic rhinitis (AR) susceptibility.MethodsBALB/c female mice (AR mother) were sensitized by intraperitoneal injection of Dermatophagoides pteronyssinus (Der p) 1 on day 1 and 7. Then they mated with normal male mice on day 8. From day 21 to 28, the female mice were intranasal challenged with Der p 1 continuously. The normal controls were given with normal saline in the same way. On postnatal day 3, Female mice and their offspring were sacrificed to detect their histopathology in nasal mucosae, cytokines in sera of mother and spleen homogenates of offspring, Treg cells count, Foxp3 mRNA expressions, and Foxp3 DNA methylation levels in spleens.ResultsCompared with the normal controls, neonatal offspring of Der p 1-stimulated female mice (AR offspring) showed the elevation of interleukin (IL)-4 (P<0.01) and IL-17 (P<0.01), the submission of IL-10 (P<0.01) in spleen homogenates. Further, Treg cells count in AR offspring decreased remarkably compared with the normal offspring (P<0.01). Though the difference of Foxp3 DNA methylation level between AR offspring and normal control offspring was not obvious, correlation analysis demonstrated that there was significantly positive correlation between Foxp3 DNA methylation level of mother and that of offspring (r=0.803, P<0.01).ConclusionsUnder the influence of Maternal AR, their neonatal offspring develop into T-helper type 2 (Th2) dominant immune state, which is closely associated with the recession of Treg cells. Foxp3 DNA methylation may be a mechanism responsible for that maternal effect but still need more studies to ensure.

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Section: Discussionmentioning

confidence: 99%

Neonatal Immune State Is Influenced by Maternal Allergic Rhinitis and Associated With Regulatory T cells

Tan

Tao

et al. 2017

Allergy Asthma Immunol Res

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“…4-5 mg alpha-tocopherol per day during lactation. A recent study has also shown a link between low vitamin E intake and miscarriages during the first trimester of pregnancy, pointing to the importance of adequate intake in women of child bearing age [22]. We respectfully disagree with the Panel's conclusion, that "a full compensation of the transitory secretion of alpha-tocopherol in breast milk is not justified for the derivation of DRVs for alpha-tocopherol for lactating women."…”

Section: Organisationmentioning

confidence: 70%

“…A recent study has also shown a link between low vitamin E intake and miscarriages during the first trimester of pregnancy, pointing to the importance of adequate intake in women of child bearing age [4]. A link between maternal alpha-tocopherol levels and development of asthma and allergies in the offspring has also been reported by several studies [22]. Therefore it is important to consider all the above data to set the adequate intake for the health of both mother and child.…”

Section: Organisationmentioning

confidence: 95%

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin E as ɑ‐tocopherol

2015

EFSA Supporting Publications

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The European Food Safety Authority (EFSA) carried out a public consultation to receive input from the scientific community and all interested parties on the draft Scientific Opinion on Dietary Reference Values (DRVs) for vitamin E as α-tocopherol, prepared by the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) and endorsed by the Panel for public consultation at its Plenary meeting on 5 February 2015. The written public consultation for this document was open from 9 March 2015 to 13 April 2015. EFSA received comments from five interested parties. EFSA and its NDA Panel wish to thank all stakeholders for their contributions. The current report summarises the outcome of the public consultation, and includes a brief summary of the comments received and how the comments were addressed. The NDA Panel prepared an updated version of the Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol taking into account the comments received. The Opinion was discussed and adopted at the NDA Plenary meeting on 11 June 2015, and is published in the EFSA Journal. © European Food Safety Authority, 2015Reproduction is authorised provided the source is acknowledged. Outcome of a public consultation on a Draft Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherolwww.efsa.europa.eu/publications 3 EFSA Supporting publication 2015:EN-844 Terms of ReferenceIn line with EFSA's policy on openness and transparency, and in order for EFSA to receive comments from the scientific community and stakeholders, EFSA shall release the Draft Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol for public consultation. The comments resulting from the public consultation shall be published in a technical report.Before its adoption by the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel), the Draft Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol needs to be revised, taking into account the comments received during the public consultation. ConsiderationUpon request from the European Commission and following previously published Scientific Opinions on Dietary Reference Values for macronutrients, energy, water, and several micronutrients, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) developed a Draft Scientific Opinion on Dietary Reference Values (DRVs) for vitamin E as α-tocopherol. In line with EFSA's policy on openness and transparency, and in order for EFSA to receive comments on its work from the scientific community and stakeholders, EFSA engages in public consultations on key issues. Accordingly, the draft Scientific Opinion was published on EFSA's website for comments (9 March to 13 April 2015) (see Appendix A). The NDA Panel prepared an updated version of the Scientific Opinion, taking into account the comments received. The updated Scientific Opinion was discussed and adopted at the NDA Plenary meeting on 11 June 2015, and is published in the EFSA Journal (EFSA NDA Panel, 20...

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“…Two recent reviews comprehensively summarized the state of the art on maternal influences on allergic responses in offspring, and discussed potential biological mechanisms [2,3]. Maternal effects on Th1 and Th2 cytokines in the offspring, as well as maternal vitamins as regulators of offspring allergic responses were highlighted [2].…”

Section: Mechanisms For Prenatal Stress and Asthma Riskmentioning

confidence: 99%

“…Maternal effects on Th1 and Th2 cytokines in the offspring, as well as maternal vitamins as regulators of offspring allergic responses were highlighted [2]. It may also be important to consider how those maternal stress-related markers can be transferred to the fetus via the placenta.…”

Section: Mechanisms For Prenatal Stress and Asthma Riskmentioning

confidence: 99%

Can prenatal maternal stress increase the risk of asthma?

Heinrich

2015

Expert Review of Respiratory Medicine

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Maternal Influences over Offspring Allergic Responses

Cited by 38 publications

References 112 publications

Neonatal Immune State Is Influenced by Maternal Allergic Rhinitis and Associated With Regulatory T cells

Neonatal Immune State Is Influenced by Maternal Allergic Rhinitis and Associated With Regulatory T cells

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin E as ɑ‐tocopherol

Can prenatal maternal stress increase the risk of asthma?

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