Effects of skim milk powder enriched with glycomacropeptide and G600 milk fat extract on frequency of gout flares: a proof-of-concept randomised controlled trial

Dalbeth, Nicola; Ames, Ruth; Gamble, Greg; Horne, Anne; Wong, Sumwai; Kuhn-Sherlock, B.; MacGibbon, Alastair; McQueen, Fiona; Reid, Ian R.; Palmano, Kate

doi:10.1136/annrheumdis-2011-200156

Cited by 89 publications

(80 citation statements)

References 14 publications

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“…The role of milk and dairy products on the risk of gout has only recently been investigated. A higher consumption of low-fat dairy products have been related to a lower incidence of gout (16) and specific milk components have been studied as possible determinants of the protective effect of milk on gout flares (18). In our study population we observed a lower consumption of milk, suggesting that the role of milk and derivates in dietary intervention for gout has not adequately underlined yet.…”

Section: N Resultscontrasting

confidence: 37%

Lifestyle and dietary habits of patients with gout followed in rheumatology settings

et al. 2016

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summary Diet and lifestyles modification are core aspects of the non-pharmacological management of gout, but a poor consistency with suggested guidelines is reported. This study aimed to investigate dietary and lifestyle habits of patients with gout followed in rheumatology settings. Data were retrieved from the baseline dataset of the KING study, a multicentre cohort study of patients with gout followed in rheumatology settings. Dietary habits were assessed with the Italian National Institute of Statistics (ISTAT) food-frequency questionnaire and compared with reported data about general population. The relative increase of exposure was estimated by standardized prevalence ratios adjusted for gender, age and geographical distribution. The study population included 446 patients, with a mean age of 63.9 years and a M/F ratio of 9:1. Compared to the Italian population, gouty patients showed a higher prevalence of obesity [1.82 (1.52-2.18)] and a higher consumption of wine [1.85 (1.48-2.32)] and beer [2.21 (1.68-2.90)], but a lower prevalence of smoking and a lower intake of liquor. They showed a lower intake of red meat [0.80 (0.71-0.91)], but a similar intake of other tested dietary factors. Gouty patients' lifestyle is still partially different from the recommended.

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Section: N Resultscontrasting

confidence: 37%

Lifestyle and dietary habits of patients with gout followed in rheumatology settings

et al. 2016

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“…These in vitro findings were confirmed in an in vivo mice model of gout where feeding with GMP and G600 resulted in an anti-inflammatory effect [16]. Recently, Dalbeth et al [15] showed that ingestion of skim milk powder enriched with G600 and GMP could reduce the frequency of gout flares with patients.…”

Section: Introductionmentioning

confidence: 78%

Tryptophan-containing milk protein-derived dipeptides inhibit xanthine oxidase

2012

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“…Помимо урикозурического действия компонентов молока предполагается, таким образом, и противовоспа-лительный эффект, механизмы которого пока не извест-ны. При этом отмечена зависимость выраженности про-тивовоспалительного и урикозурического ответа от дозы принятых веществ [66].…”

Section: мясо и морепродук тыunclassified

Diet in Gout and Hyperuricemia

Желябина¹,

Елисеев²

2017

Naučno-praktičeskaâ revmatologiâ

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The paper reviews the most important works devoted to the study of the impact of individual foods and food components on the risk of gout, its clinical manifestations and the level of uricemia. It considers some mechanisms probably underlying the impact of dietary patterns on the level of uricemia. It is shown that the available data on possible alterations in the diet with their proper application can considerably affect both the incidence of gout and the course of the current disease.

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Effects of skim milk powder enriched with glycomacropeptide and G600 milk fat extract on frequency of gout flares: a proof-of-concept randomised controlled trial

Abstract: This is the first reported controlled trial of dietary intervention in patients with gout, and suggests that SMP enriched with GMP and G600 may reduce the frequency of gout flares.

Cited by 89 publications

References 14 publications

Lifestyle and dietary habits of patients with gout followed in rheumatology settings

Lifestyle and dietary habits of patients with gout followed in rheumatology settings

Tryptophan-containing milk protein-derived dipeptides inhibit xanthine oxidase

Diet in Gout and Hyperuricemia

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