Effects of silver nanoparticles (AgNPs) on hematological parameters of rainbow trout, Oncorhynchus mykiss

Imani, Mohsen; Halimi, Mostafa; Khara, H

doi:10.1007/s00580-014-1927-5

Cited by 47 publications

(30 citation statements)

References 13 publications

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“…Shaluei et al (2013) conducted subacute toxicity studies of AgNP on silver carp and found that RBC and %Hct levels in exposed hosts were significantly lowered after a week. Imani et al, (2015) reported a decrease in %Hct levels in rainbow trout after 8 days of AgNP exposure. Likewise, %Hct and the levels of RBC after AgNP exposure in the tilapia were significantly decreased from Weeks 1-8.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Analysis of hematologic alterations, immune responses and metallothionein gene expression in Nile tilapia (Oreochromis niloticus) exposed to silver nanoparticles

Thummabancha

Onparn

Srisapoome

2016

Journal of Immunotoxicology

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Section: Discussionmentioning

confidence: 97%

“…Hematological parameters are also important measures reflective of fish health status (Cheraghi et al 2013;Imani et al 2015). Shaluei et al (2013) conducted subacute toxicity studies of AgNP on silver carp and found that RBC and %Hct levels in exposed hosts were significantly lowered after a week.…”

Section: Discussionmentioning

confidence: 99%

Analysis of hematologic alterations, immune responses and metallothionein gene expression in Nile tilapia (Oreochromis niloticus) exposed to silver nanoparticles

Thummabancha

Onparn

Srisapoome

2016

Journal of Immunotoxicology

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“…Extensive accumulation from exposure to NPs of Ag, TiO 2 , CuO, and ZnO has been reported on the gills of fish (Zhao et al, 2011; Boyle et al, 2013a, 2013b; Hao et al, 2013; Imani et al, 2014; Ates et al, 2015). Because NP aggregates are too large to penetrate into gill tissue, the accumulation is ascribed to adsorption/adhesion of NPs on the gill epithelial surfaces to varying degrees as determined by NP type, concentration and exposure time (Kaya et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Lee et al (2014) reported transient increases in GOT and GPT values of carp during chronic exposure to ZnO NPs, while serum ALP and LDH did not change. Exposure to more toxic AgNPs in contrast increased GOT, GPT, ALP, and LDH levels significantly in rainbow trout (Imani et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

Chronic exposure of tilapia (Oreochromis niloticus) to iron oxide nanoparticles: Effects of particle morphology on accumulation, elimination, hematology and immune responses

et al. 2016

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Effects of chronic exposure to alpha and gamma iron oxide nanoparticles (α-Fe2O3 and γ-Fe2O3 NPs) were investigated through exposure of tilapia (Oreochromis niloticus) to 0.1, 0.5 and 1.0 mg/L (9.2×10−4, 4.6×10−3 and 9.2×10−3 mM) aqueous suspensions for 60 days. Fish were then transferred to NP-free freshwater and allowed to eliminate ingested NPs for 30 days. The organs, including gills, liver, kidney, intestine, brain, spleen, and muscle tissue of the fish were analyzed to determine the accumulation, physiological distribution and elimination of the Fe2O3 NPs. Largest accumulation occurred in spleen followed by intestine, kidney, liver, gills, brain and muscle tissue. Fish exposed to γ-Fe2O3 NPs possessed significantly higher Fe in all organs. Accumulation in spleen was fast and independent of NP concentration reaching to maximum levels by the end of the first sampling period (30th day). Dissolved Fe levels in water were very negligible ranging at 4–6 μg/L for α-Fe2O3 and 17–21 μg/L for γ-Fe2O3 NPs (for 1 mg/L suspensions). Despite that, Fe levels in gills and brain reflect more dissolved Fe accumulation from metastable γ-Fe2O3 polymorph. Ingested NPs cleared from the organs completely within 30-day elimination period, except the liver and spleen. Liver contained about 31% of α- and 46% of γ-Fe2O3, while spleen retained about 62% of α- and 35% of the γ-polymorph. No significant disturbances were observed in hematological parameters, including hemoglobin, hematocrit, red blood cell and white blood cell counts (p > 0.05). Serum glucose (GLU) levels decreased in treatments exposed to 1.0 mg/L of γ-Fe2O3 NPs at day 30 (p < 0.05). In contrast, GLU levels increased during the elimination period for 1.0 mg/L α-Fe2O3 NPs treatments (p < 0.05). Transient increases occurred in glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and lactate dehydrogenase (LDH). Serum Fe levels did not change during exposure (p > 0.05), but increased significantly within elimination period due to mobilization of ingested NPs from liver and spleen to blood. Though respiratory burst activity was not affected (p > 0.05), lysozyme activity (LA) was suppressed suggesting an immunosuppressive effects from both Fe2O3 NPs (p < 0.05). In contrast, myeloperoxidase (MPO) levels increased significantly in treatments exposed to α-Fe2O3 NPs (p < 0.05), and the effect from γ-polymorph was marginal (p ≥ 0.05). The results indicate that morphological differences of Fe2O3 NPs could induce differential uptake, assimilation and immunotoxic effects on O. niloticus under chronic exposure.

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“…Rajkumar et al showed that a 7 days sub-acute exposure to AgNPs can impact on RBC and WBC of Labeo rohita [23]. Imani et al showed that short term exposure of rainbow trout to AgNPs increased the values of RBCs, WBCs, and mean corpuscular hemoglobin concentration, but decreased the values of hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin [24].…”

Section: Introductionmentioning

confidence: 99%

Chronic effect of waterborne colloidal silver nanoparticles on plasma biochemistry and hematology of rainbow trout (Oncorhynchus mykiss)

Johari

Kalbassi

2016

J Coast Life Med

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Effects of silver nanoparticles (AgNPs) on hematological parameters of rainbow trout, Oncorhynchus mykiss

Cited by 47 publications

References 13 publications

Analysis of hematologic alterations, immune responses and metallothionein gene expression in Nile tilapia (Oreochromis niloticus) exposed to silver nanoparticles

Analysis of hematologic alterations, immune responses and metallothionein gene expression in Nile tilapia (Oreochromis niloticus) exposed to silver nanoparticles

Chronic exposure of tilapia (Oreochromis niloticus) to iron oxide nanoparticles: Effects of particle morphology on accumulation, elimination, hematology and immune responses

Chronic effect of waterborne colloidal silver nanoparticles on plasma biochemistry and hematology of rainbow trout (Oncorhynchus mykiss)

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