Effects of Short- and Long-Term Hypercholesterolemia on Contrast-Induced Acute Kidney Injury

Yang, Dingwei; Lin, Song; Yang, Dingping; Li, Wei; Shang, Wenjun

doi:10.1159/000335077

Cited by 25 publications

(26 citation statements)

References 37 publications

(26 reference statements)

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“…Recently, Yang et al found that CM administration increased serum creatinine levels and induced severe renal tubular necrosis in rats fed the high-cholesterol diet for 8 weeks but not in rats fed the normal diet or high-cholesterol diet for 2 weeks. 9 Our study also found that in CM-injected rats with hypercholesterolemia vacuolar degeneration of tubular epithelial cells, tubular dilation, protein cast, loss of tubular brush border, and increased epithelial cell shedding were observed. These studies demonstrated that hypercholesterolemia was an important risk factor for radiocontrast nephrotoxicity.…”

Section: Discussionsupporting

confidence: 76%

“…The rats were randomly divided into normal diet group (NN, n ¼ 8) and high cholesterol supplemented dietary group (HN, 4% cholesterol and 1% cholic acid, n ¼ 32). 9 At the end of 8 weeks, 1 rat given normal diet died and 4 rats given high cholesterol supplemented dietary died, then the rats with high cholesterol diet were randomly divided into four subgroups (7/group): high cholesterol diet group (HN), high cholesterol plus diatrizoate group (HH), high cholesterol plus diatrizoate plus MTP131 group (HM), and high cholesterol plus diatrizoate plus SPI20 group (HS). All experiments were approved by the Medical Science Animal Care Committee of the Central South University.…”

Section: Reagents and Animalsmentioning

confidence: 99%

“…of the CM (diatrizoate meglumine) with 300 mg I/mL were given through a caudal vein in 2 min to induce CIAKI; [9][10][11][12] at the same time, the other two groups were given equal volume of normal saline, 24 h before and after CM injection and half hour just before CM administration, the rats of group HM and HS were given injection of MTP131 or SPI 20 (3 mg/kg) into peritoneal cavity for 3 times, rats from group NN, HN, and HH were also given equal volume of normal saline. All rats were maintained in individual metabolic cages with free access to water to collect 24-h urine samples.…”

Section: Experimental Protocolmentioning

confidence: 99%

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Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia

et al. 2013

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Objective: The objective of this study is to evaluate the effect and mechanism of mitochondriatargeted peptides (MTP131 and SPI20) on contrast-induced acute kidney injury (CI-AKI) in rats with hypercholesterolemia. Method: Forty SD rats were randomly divided into normal diet group (NN, n ¼ 8) and high cholesterol supplemented dietary group (HN, n ¼ 32). At the end of 8 weeks, the group HN was divided into four subgroups. All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times. Blood, urine and renal tissue samples were prepared to determine biochemical parameters. The renal pathological changes were evaluated by hematoxylin and eosin staining and scored semiquantitatively, The protein expression of renal NOX4 was also measured by Western blotting. Results: In diatrizoate-injected rats, Serum creatinine (Scr), fractional excretion of sodium (FeNa%), fractional excretion of potassium (FeK%), pathological scores, renal malondialdehyde (MDA) content, the NADPH oxidase activity and the expression of NOX4 in kidney tissue were significantly increased (p50.01). In the groups pretreated with MTP131 or SPI20, the levels of Scr, FeNa%, FeK%, MDA content and NADPH oxidase activity in renal tissue decreased (p50.01), the levels of renal super oxygen dehydrogenises and ATPase activity increased (p50.01). The renal injuries induced by contrast media (CM) were alleviated. Conclusion: MTP131 and SPI20 might protect acute kidney injury induced by CM in rats with hypercholesterolemia.

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Section: Discussionsupporting

confidence: 76%

Section: Reagents and Animalsmentioning

confidence: 99%

Section: Experimental Protocolmentioning

confidence: 99%

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Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia

et al. 2013

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“…The elevated urea level in hypercholesterolemic rats is likely due to increased amino acid catabolism, impaired kidney function or liver damage (Pedraza et al, 2004). Yang et al (2012) observed an increased serum creatinine levels and induced severe renal tubular necrosis in rats fed the high-cholesterol diet for 8 weeks but not in rats fed the normal diet or high-cholesterol diet for 2 weeks. The authors concluded that long-term hypercholesterolemia appeared to be a risk factor for contrast-induced acute kidney injury (CI-AKI), which might be associated with disorders in intrarenal prostaglandins and abnormalities in renal nitric oxide system induced by lipid peroxidation.…”

Section: Discussionmentioning

confidence: 83%

The Possible Improving Effects of γ-Irradiated and/or Extruded Soy Flour on Hypercholesterolemic Rats

et al. 2013

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Hypercholesterolemia is serious conditions that can cause fatal complications without careful management. Among the dietary supplementation with functional food, soybeans possess variety of antioxidant compounds that may lower incidence of hypercholesterolemia and degenerative cardiovascular disease. Thus, the purpose of this study is to determine the effect of gammairradiated and/or extruded soy flour on hypercholesterolemic rats. Processing of soy flour by γ-irradiation and/or extrusion reduced the amount of antinutritional factors such as tannin and trypsin inhibitor and resulted in different changes in the total amino acids and fatty acid contents. The animals maintained on the HCD showed remarkable decrease in the level of HDL-C associated with significant increase in the values of serum total lipid, total cholesterol, triglyceride, LDL-C, vLDL-C and the risk ratio in addition to serum concentration of urea, creatinine and uric acid in comparison with those of the control group. However, dietary supplementation of raw and treated soy flour resulted in reduction in the bad changes induced by HCD in the above mentioned parameters. In conclusion, treated soy flour supplementation in diet of rats pointed out to its hypocholesterolemic effect and its ability to improve lipid profile and kidney function of hypercholesterolemic rats.

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“…[21][22][23] However, the findings of most of the studies are inconsistent, except for the positive effect of hydration or hydration in combination with N-acetylcysteine (NAC) or sodium bicarbonate before the procedure. 24 Recently, Onbaşılı et al were the first to report that TMZ-a cellular anti-ischemic agent-was effective in preventing CIN in patients undergoing coronary procedures.…”

Section: Discussionmentioning

confidence: 99%

The first histopathological evidence of trimetazidine for the prevention of contrast-induced nephropathy

Akgüllü

Saruhan²,

Eryılmaz

et al. 2014

Renal Failure

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Aim: We aimed to investigate the prophylactic effects of trimetazidine (TMZ) against contrastinduced nephropathy (CIN) in rat kidneys. Methods and results: 28 Wistar rats were divided into 4 groups of 7 rats each (control (C), contrast media (CM) TMZ, trimetazidin + contrast media groups (TMZ + CM). The administration of TMZ solution was done on d2, d3 and d4. Fifth day, contrast media was administered at a single dose. On d6 scarification was performed. The oxidant/antioxidant parameters were measured and histopathological scores were performed in kidney tissues. Most of the histopathological scores were significantly higher in the CM group as compared to other groups. Moreover, the scores of the TMZ + CM and C groups were not statistically different. CM group, had significantly higher levels of MDA compared to the C and CM + TMZ groups (562.82 ± 38.15 vs. 419.15 ± 49.01 and 507.34 ± 14.16 01 nmol/mg protein respectively) (p50.001). CM group had significantly lower levels of SOD as compared to C, CM + TMZ and TMZ groups (p50.05). Conclusion: To the best of our knowledge, this study for the first time, histopathologically demonstrated the effectiveness of TMZ for the prevention of CIN.

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Effects of Short- and Long-Term Hypercholesterolemia on Contrast-Induced Acute Kidney Injury

Cited by 25 publications

References 37 publications

Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia

Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia

The Possible Improving Effects of γ-Irradiated and/or Extruded Soy Flour on Hypercholesterolemic Rats

The first histopathological evidence of trimetazidine for the prevention of contrast-induced nephropathy

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