The first histopathological evidence of trimetazidine for the prevention of contrast-induced nephropathy

Abstract

Aim: We aimed to investigate the prophylactic effects of trimetazidine (TMZ) against contrastinduced nephropathy (CIN) in rat kidneys. Methods and results: 28 Wistar rats were divided into 4 groups of 7 rats each (control (C), contrast media (CM) TMZ, trimetazidin + contrast media groups (TMZ + CM). The administration of TMZ solution was done on d2, d3 and d4. Fifth day, contrast media was administered at a single dose. On d6 scarification was performed. The oxidant/antioxidant parameters were measured and histopathological scores were performed in kidney tissues. Most of the histopathological scores were significantly higher in the CM group as compared to other groups. Moreover, the scores of the TMZ + CM and C groups were not statistically different. CM group, had significantly higher levels of MDA compared to the C and CM + TMZ groups (562.82 ± 38.15 vs. 419.15 ± 49.01 and 507.34 ± 14.16 01 nmol/mg protein respectively) (p50.001). CM group had significantly lower levels of SOD as compared to C, CM + TMZ and TMZ groups (p50.05). Conclusion: To the best of our knowledge, this study for the first time, histopathologically demonstrated the effectiveness of TMZ for the prevention of CIN.

Trimetazidine Decreases Risk of Contrast-Induced Nephropathy in Patients With Chronic Kidney Disease

“…12,13 A recent animal model study demonstrated that administration of TMZ is a protective tool against the histopathologic changes in CIN. 14 The purpose of this meta-analysis was to synthesize data regarding the efficacy of TMZ in addition to NS + NAC versus NS + NAC alone for preventing CIN in coronary angiography and percutaneous coronary interventions.…”

“…12,13 A recent animal model study demonstrated that administration of TMZ is a protective tool against the histopathologic changes in CIN. 14…”

Trimetazidine Influence on Filtration and Tubulointerstitial Function of Kidneys in Ischemic Heart Disease Patients With Chronic Heart Failure and Renal Dysfunction

“…Так, в мета-анализе РКИ Nadkarni GN, et al было продемонстрировано, что триметазидин у больных с исходным высоким уровнем сывороточного креатинина в диапазоне 1,3-2,0 мг/дл предупреждал развитие КИН на 89% (95% ДИ: 0,06-0,16, p=0,01) [4]. Причем профилактический эффект триметазидина в отношении КИН подтвержден в эксперименте на животных гистологически [7].…”

Rho Kinase Inhibitor, Fasudil, Attenuates Contrast‐induced Acute Kidney Injury

“…The PAS-stained tissue sections were viewed under light microscopy, and 10 microscope fields per section were examined at 4009 magnification. Acute renal injury was scored semi-quantitatively using tubular degeneration score (TD) as previously described [20].…”