Effects of Selenium-Enriched Protein fromGanoderma lucidumon the Levels of IL-1βand TNF-α, Oxidative Stress, and NF-κB Activation in Ovalbumin-Induced Asthmatic Mice

Min-chang, Guan; Wei-hong, Tang; Xu, Zhiyong; Sun, Jin

doi:10.1155/2014/182817

Cited by 16 publications

(3 citation statements)

References 17 publications

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“…S7). It also has been reported that by inhibiting the activation of the PI3K/AKT and ERK signaling pathways and endoplasmic reticulum stress, Se can suppress oxidative-stress-enhanced vascular smooth muscle cell calcification60, further reducing the levels of IL-1β, TNF- α, oxidative stress, and NF- κ B activation61. On the contrary, a diet with a Se deficiency weakens antioxidant capacity62.…”

Section: Discussionmentioning

confidence: 99%

Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species

Deng

Niu

Zhou

et al. 2017

Sci Rep

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Reducing oxidative stress (ROS) have been demonstrated effective for steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH). Selenium (Se) plays an important role in suppressing oxidative stress and has huge potential in ONFH treatments. However the Se has a narrow margin between beneficial and toxic effects which make it hard for therapy use in vivo. In order to make the deficiency up, a control release of Se (Se@SiO2) were realized by nanotechnology modification. Porous Se@SiO2 nanocomposites have favorable biocompatibility and can reduced the ROS damage effectively. In vitro, the cck-8 analysis, terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) stain and flow cytometry analysis showed rare negative influence by porous Se@SiO2 nanocomposites but significantly protective effect against H2O2 by reducing ROS level (detected by DCFH-DA). In vivo, the biosafety of porous Se@SiO2 nanocomposites were confirmed by the serum biochemistry, the ROS level in serum were significantly reduced and the curative effect were confirmed by Micro CT scan, serum Elisa assay (inflammatory factors), Western blotting (quantitative measurement of ONFH) and HE staining. It is expected that the porous Se@SiO2 nanocomposites may prevent steroid-induced ONFH by reducing oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species

Deng

Niu

Zhou

et al. 2017

Sci Rep

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“…It is also required for proper immune response (Hawkes and others ) and reproductive function (Ahsan and others ). Importantly, it has been demonstrated that polysaccharides (for example, SeGLP‐2B‐1) isolated from Se‐enriched G. lucidum showed antitumor activity through inducement of apoptosis in breast cancer cells (Shang and others ), whereas proteins isolated from Se‐supplemented mushrooms exhibited significant immunomodulatory properties (Min‐Chang and others ).…”

Section: Introductionmentioning

confidence: 99%

Potential of Cultivated Ganoderma lucidum Mushrooms for the Production of Supplements Enriched with Essential Elements

Rzymski

Mleczek

Niedzielski

et al. 2016

Journal of Food Science

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Ganoderma lucidum is an important medicinal mushroom species and there is continuous interest in its bioactive properties. This study evaluated whether it may additionally serve as a nutritional supplement for the trace elements: selenium (Se), copper (Cu), and zinc (Zn). Mushrooms were cultivated on substrates enriched with 0.1 to 0.8 mM of inorganic Se alone or in combination with Zn and/or Cu. Supplementation increased accumulation of the elements in fruiting bodies regardless of the applied cultivation model. G. lucidum demonstrated the ability to accumulate significant amounts of organic Se, maximally amounting to (i) over 44 mg/kg when the substrate was supplemented only with Se, (ii) over 20 mg/kg in the Se+Cu model, (iii) over 25 mg/kg in the Se+Zn model, and (iv) 15 mg/kg in the Se+Cu+Zn model. The accumulation of Cu and Zn steadily increased with their initial substrate concentrations. Maximum concentrations found after supplementation with 0.8 mM amounted to over 55 mg/kg (Se+Zn) and 52 mg/kg (Se+Cu+Zn) of Zn, and 29 mg/kg (Se+Cu) and over 31 mg/kg (Se+Cu+Zn) of Cu. The greater the supplemented concentration and number of supplemented elements, the lower the biomass of G. lucidum fruiting bodies. Nevertheless, it still remained high when the substrate was supplemented up to 0.4 mM with each element. These results highlight that G. lucidum can easily incorporate elements from the substrate and that, when biofortified, its dried fruiting bodies may serve as a nutritional source of these essential elements.

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“…However, the results of previous animal studies have shown that Se-enriched protein from Ganoderma lucidum can increase the GSH level in mice, playing a vital role in the antioxidant defense system. 72 Liu et al…”

Section: Reduced Gsh Gssg and Total Gsh (T-gsh) Concentrationsmentioning

confidence: 99%

Antioxidant activity of SSeCAHK in HepG2 cells: a selenopeptide identified from selenium-enriched soybean protein hydrolysates

Zhang

et al. 2021

RSC Adv.

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Effects of Selenium-Enriched Protein fromGanoderma lucidumon the Levels of IL-1βand TNF-α, Oxidative Stress, and NF-κB Activation in Ovalbumin-Induced Asthmatic Mice

Cited by 16 publications

References 17 publications

Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species

Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species

Potential of Cultivated Ganoderma lucidum Mushrooms for the Production of Supplements Enriched with Essential Elements

Antioxidant activity of SSeCAHK in HepG2 cells: a selenopeptide identified from selenium-enriched soybean protein hydrolysates

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